JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (3): 95-99.doi: 10.6040/j.issn.1673-3770.0.2016.485

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Research advances on Argonaute2 and its role in human tumors.

ZHANG Yanhui, DONG Pin   

  1. Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai 200080, China
  • Received:2016-11-20 Online:2017-06-16 Published:2017-06-16

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Abstract: With the rapid development of proteomics, proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex(RISC), selfcatalysis and overexpression, Argonaute2 plays an important role in human tumorigenesis and progression, and is becoming a research focus. In this article, we will review the research advances on the structure, function and mechanism of Argonaute2 in tumor development.

Key words: GW182, Tumor, RNA-induced silencing complex, Post-translational modification, Argonaute2

CLC Number: 

  • R767.19
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