JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (3): 91-94.doi: 10.6040/j.issn.1673-3770.0.2016.392

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The significance of Maspin and Ets1 in laryngeal squamous carcinoma.

AN Yongming1, MU Wenli2a, TIAN Yanxun3, LI Wei2b, WU Yanqiao4   

  1. 1. Department of Otolaryngology, Jianguo Hospital of Zhangjiakou, Zhangjiakou 075000, Hebei, China;2a. Department of Gastroenterology, 2b. Department of Pathology, The 251st Hospital of Chinese PLA, Zhangjiakou 075000, Hebei, China;3. Department of Otolaryngology, Peoples Hospital of Xingtai, Xingtai 054000, Hebei, China;4. Department of Otolaryngology, Bethune International Peace Hospital, Shijiazhuang 050000, Hebei, China
  • Received:2016-09-07 Online:2017-06-16 Published:2017-06-16

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Abstract: Objective To investigate the significance of Maspin, an anti-oncogene, and the transcription factor Ets1 in laryngeal squamous carcinoma. Methods The expression of Maspin and Ets1 was evaluated in 70 samples of laryngeal squamous carcinoma and 30 samples of non-cancerous adjacent tissues by immunohistochemistry(EnVisionTM, Fuzhou Mai Xin Biological Ltd. Co., China). Results The difference in the positive rates of expression of Maspin and Ets1 between the laryngeal squamous carcinoma and adjacent samples was statistically significant(P<0.05)Positive expression of Maspin was associated with tumor size, histological classification, TNM staging, and Ki-67 expression(P<0.05). Additionally, positive expression of Ets1 was associated with histological classification, TNM staging, lymph node metastasis, and Ki-67 expression(P<0.05). However, there was negative correlation between the expression of Maspin and Ets1 in laryngeal squamous carcinoma. Conclusion Maspin and Ets1 are involved in the progression of laryngeal squamous carcinoma; their expression not only reflects the malignant degree of laryngeal squamous carcinoma, but also is helpful in further expounding related mechanisms in the development of laryngeal squamous carcinoma.

Key words: Ets1, Immunohistochemistry, Maspin, Laryngeal squamous carcinoma

CLC Number: 

  • R739.65
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