Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 9-13.doi: 10.6040/j.issn.1673-3770.1.2018.043

• Invited Review • Previous Articles     Next Articles

Endotypes and precision medicine in chronic sinusitis treatment

Huabin LI(),Yuting LAI,Wenxiu JIANG   

  1. Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China
  • Received:2018-12-03 Revised:2019-04-11 Online:2019-05-20 Published:2019-08-07
  • Contact: Huabin LI E-mail:noseli@163.com

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Abstract:

Chronic rhinosinusitis (CRS) is a common otolaryngologic disease, with a complex intrinsic pathological mechanism. Traditional medicine and surgery do not fully treat CRS. In recent years, precision medicine has been used to develop new biological agents to treat CRS based on its phenotype. This article reviews the current endotypes of CRS that have therapeutic significance, including type II inflammatory, eosinophilic, epithelial barrier function, and epithelium-derived cytokine endotypes, and those that are still in the theoretical stage of research, including the non-type II inflammatory phenotype and tissue remodeling.

Key words: Chronic rhinosinusitis, Pathogenesis, Endotype, Precision medicine, Biologic products

CLC Number: 

  • R765.41
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