Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (3): 36-41.doi: 10.6040/j.issn.1673-3770.1.2019.021

• Research Progress • Previous Articles     Next Articles

Current status of genetic research on allergic rhinitis

Meiping LU1(),Lei CHENG1,2   

  1. 1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University
    2. International Centre for Allergy Research, Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2019-04-15 Revised:2019-05-01 Online:2019-05-20 Published:2019-08-08
  • Contact: Meiping LU E-mail:lmp@njmu.edu.cn

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Abstract:

Allergic rhinitis is a non-infectious inflammatory disease of the nasal mucosa caused by a combination of genetic and environmental factors. Although a fair understanding of its pathogenesis already exits and research on genetic factors associated with this condition has made significant progress, these studies are still limited to achieving statistically significant results; however, their clinical applications have a long way to go. This article mainly introduces the research strategy on genes related to allergic rhinitis, their interaction with the environment, the sharing overlap of allergic disease genes, epigenetic modifications, and the direction of gene research transformation.

Key words: Allergic rhinitis, Genes, Environment, Gene-environment interaction, Epigenetics, Precision medicine

CLC Number: 

  • R765.4
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