Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (4): 124-130.doi: 10.6040/j.issn.1673-3770.0.2018.517

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Soft palate surgeries with hyoid bone suspension for obstructive sleep apnea hypopnea syndrome with glossoptosis: a meta-analysis

JI Di,CHEN Xiang, YU Lin   

  1. Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Online:2019-07-20 Published:2019-07-22

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Abstract: Objective To assess the efficacy of soft palate surgeries with hyoid bone suspension for obstructive sleep apnea syndrome(OSAS)with both obstructions of palatopharyngeal plane and hyopharyngeal planes obstructions. Methods An electronic search was conducted on the VIP, CNKI, and Pubmed databases and several studies were selected according to the inclusion and exclusion criteria. Subsequently, the literature quality was evaluated by MINORS and data were extracted to perform qualitative description. Data about effects were meta-analyzed by RevMan 5.3. Results A total of 13 self-controlled trials or RCTs involving 310 patients were included in the present meta-analysis. All the patients presented moderate to severe OSAHS and were followed up for more than 3 months following the surgeries. Most of the trials were self-controlled, whereas two of them were RCTs. According to the MINORS, while two studies represented a low quality research(0-12 points in total), two reported a high quality(19-24 points in total), whereas the remaining nine studies were characterized by a moderate quality(13-18 points in total). Of the 11 studies contrasting the apnea hypopnea index(AHI), 2 were asymmetric at the bottom of the funnel plots, suggesting a publication bias. Furthermore, 2 studies contrasting the respiratory disturbance index(RDI)were present, whereas 13 investigations contrasting the lowest arterial oxygen saturation(LSaO2)were found. Of them, 4 were asymmetric at the bottom of the funnel plots, indicating a publication bias. The meta-analyses described a significant improvement in AHI, RDI, LSaO2, AHI 45.61,95% CI(42.48,48.73),P<0. 001,RDI 35.26,95% CI(22.47,48.04),P<0.001,LSaO2-20.16,95% CI(-24.99,-15.33),P<0.001. A significant heterogeneity was observed in the meta-analysis, while the sensitivity analysis indicated Lin Ling’s result to be the cause. Conclusion Although most studies are moderate quality self-controlled trials, a larger sample size is needed. Soft palate surgeries with hyoid bone suspension are effective in reducing AHI and RDI and enhancing LSaO2, even though additional evidences are warranted to validate their effects.

Key words: Obstructive sleep apnea syndrome, Hyoid bone suspension, Meta-analysis

CLC Number: 

  • R766.7
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