Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 125-130.doi: 10.6040/j.issn.1673-3770.0.2020.102

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Research progress on the relationship between the C2H2 zinc finger protein family and laryngeal cancer

LI WenjingOverview,LIU MingGuidance   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China
  • Published:2021-02-01

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Abstract: Laryngeal cancer is one of the most common malignancies in head and neck cancer. Although continuous progress is being made in the diagnosis and treatment of laryngeal cancer, patient survival rates have not greatly improved. Cysteine-2/histidine-2(C2H2)-type zinc finger proteins(ZNFs), the largest family of transcription factors in humans, are characterized by multiple tandemly arranged zinc fingers. C2H2-type ZNFs are involved in normal biological processes such as transcriptional regulation, organ and tissue development, and differentiation; however, they are also associated with the occurrence and development of cancer. Studies have shown that the abnormal expression of various C2H2-type ZNFs is closely related to the clinicopathologic features and prognosis of cancers. This paper primarily reviews the progress of research on the relationship between C2H2-type ZNFs and laryngeal cancer.

Key words: Laryngeal cancer, C2H2-type zinc finger proteins, Tumor growth, Tumor suppression

CLC Number: 

  • R739
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[4] To investigate the swallowing function recovery on 23 cases of supraglottic laryngeal carcinoma postoperation. MethodsFrom 2016 to 2019, a retrospective swallowing function analysis was performed on 23 cases of supraglottic laryngeal carcinoma. All of the patients underwent horizontal hemilaryngectomy and reconstruction with tongue flap. The M.D. Anderson Dysphasia Inventory(MDADI)was used to evaluate the swallowing function from emotional dimension, social function dimension, and physiological dimension before and after operation. Results2 patients died during follow-up period.1 case lost follow-up. 20 patients recovered to normal diet. The overall swallowing median score was 90.00［80.00,100.00］, and the postoperative score median was 80.00［80.00,80.00］(P=0.359).The median score of emotion dimension was 91.67［77.50,93.33］, 80.00［80.00,83.33］(P=0.065)after operation. The median score of social function was 90.00［80.00,96.00］before surgery, and 84.00［80.00,92.00］(P=0.587)after surgery. Physiological function median score was 83.75［76.25,89.38］, 80.00［75.00,84.38］(P=0.018)after surgery. ConclusionTongue flap can improve the swallowing function and the quality of patient life after the horizontal hemilaryngectomy.. The swallowing function recovery study on tongue flap after horizontal hemilaryngectomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(5): 127-131.
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