Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (4): 8-11.doi: 10.6040/j.issn.1673-3770.0.2020.421

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Comparative study of holmium and CO2 laser surgeries for early glottic carcinoma

CHEN Guoping, FU Minyi, YE Fei, XU Jianhui   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Zhongshan People's Hospital, Zhongshan 528403, Guangdong, China
  • Published:2021-08-05

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Abstract: Objective To compare the clinical efficacies of holmium and CO2 lasers in the treatment of early glottic carcinoma. Methods The clinical data of 91 patients with early glottic laryngeal carcinoma treated by laser surgery were retrospectively analyzed(Tis, T1N0M0). Based on the treatment methods, the patients were divided into the holmium(56 cases)and CO2(35 cases)laser surgery groups. The duration of surgery, blood loss, complications, hospital stay, wound recovery time, and survival rate were analyzed in the two groups. Results There were no statistically significant differences between the postoperative pain scores(P=0.55), hospital stay durations(P=0.99), complications rates(P=0.43), recurrence rates(P=0.59), and laryngeal preservation rates of the Holmium and CO2 laser groups(P=0.64). The blood loss(P=0.02)and the durations of surgery(P<0.01)and wound healing of the two groups(P<0.01)were statistically significant. There was no significant difference between the 3-year survival rates of the two groups(P=0.69). Conclusion Holmium and CO2 laser cordectomies have the same effect in the treatment of early glottic carcinoma, and the duration of the former is shorter. With familiarity with the application of the two types of laser, patients can avoid open surgery and undergo minimally invasive treatment of tumors.

Key words: Early glottic carcinoma, Holmium laser, CO2 laser, Laser surgery, Survival rate

CLC Number: 

  • R766.9
[1] 黄志刚. CO2激光手术治疗咽喉部肿瘤[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 1-3. doi:10.6040/j.issn.1673-3770.1.2018.022. HUANG Zhigang. Treatment of throat tumors with CO2 laser[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(6): 1-3. doi:10.6040/j.issn.1673-3770.1.2018.022.
[2] 陈婕, 王家东. 激光在喉癌治疗中的应用[J]. 现代肿瘤医学, 2010, 18(3): 628-630. doi:10.3969/j.issn.1672-4992.2010.03.080. CHEN Jie, WANG Jiadong. Laser sugery for laryngeal carcinomas[J]. J Mod Oncol, 2010, 18(3): 628-630. doi:10.3969/j.issn.1672-4992.2010.03.080.
[3] Remacle M, Eckel HE, Antonelli A, et al. Endoscopic cordectomy. a proposal for a classification by the Working Committee, European Laryngological Society[J]. Eur Arch Oto-Rhino-Laryngol, 2000, 257(4): 227-231. doi:10.1007/s004050050228.
[4] Knudsen BE. Laser fibers for holmium: YAG lithotripsy: what is important and what is new[J]. Urol Clin North Am, 2019, 46(2): 185-191. doi:10.1016/j.ucl.2018.12.004.
[5] 毛庆杰, 王建山, 范红梅, 等. 不同功率钬激光对咽喉部离体组织的生物学效应[J]. 中国耳鼻咽喉头颈外科, 2015, 22(4): 213-214. doi:10.16066/j.1672-7002.2015.04.017.
[6] 王红洛, 李英, 范崇盛, 等. 喉癌前病变钬激光治疗的临床观察[J]. 临床耳鼻咽喉科杂志, 2003, 17(9): 570. doi:10.3969/j.issn.1001-1781.2003.09.031.
[7] 邵骏, 于金超. 钬激光治疗咽喉部疾病32例[J]. 中国眼耳鼻喉科杂志, 2012,12(1): 42-43. doi:10.14166/j.issn.1671-2420.2012.01.020. SHAO Jun, YU Jinchao. Therapeutic effect of Ho: YAG laser on laryngopharynx diseases in 32 cases[J]. Chin J Ophthalmol Otorhinolaryngol, 2012,12(1): 42-43. doi:10.14166/j.issn.1671-2420.2012.01.020.
[8] 张军, 王丽权, 李唐英. 钬激光手术治疗早期声门型喉癌疗效分析[J]. 中国耳鼻咽喉头颈外科, 2010,17(10): 523-525. doi:10.16066/j.1672-7002.2010.10.008. ZHANG Jun, WANG Liquan, LI Tangying. Curative effect of holmium laser surgery on early glottic cancer[J]. Chin Arch Otolaryngol - Head Neck Surg, 2010,17(10): 523-525. doi:10.16066/j.1672-7002.2010.10.008.
[9] 李文明, 魏东敏, 钱晔, 等. 支撑喉镜下CO2激光治疗喉癌的疗效分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 13-17. doi:10.6040/j.issn.1673-3770.1.2018.025. LI Wenming, WEI Dongmin, QIAN Ye, et al. Evaluate the curative effect of CO2 laser in treatment of laryngeal carcinoma[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(6): 13-17. doi:10.6040/j.issn.1673-3770.1.2018.025.
[10] Piazza C, Mangili S, Bon FD, et al. Preoperative clinical predictors of difficult laryngeal exposure for microlaryngoscopy: the Laryngoscore[J]. Laryngoscope, 2014, 124(11): 2561-2567. doi:10.1002/lary.24803.
[11] Peretti G, Piazza C, Mora F, et al. Reasonable limits for transoral laser microsurgery in laryngeal cancer[J]. Curr Opin Otolaryngol Head Neck Surg, 2016, 24(2): 135-139. doi:10.1097/moo.0000000000000240.
[12] Rucci L, Romagnoli P, Scala J. CO2 laser therapy in Tis and T1 glottic cancer: indications and results[J]. Head Neck, 2010, 32(3): 392-398. doi:10.1002/hed.21200.
[13] Ding S, Huang J, Huang Z, et al. Variation in prognosis of early laryngeal carcinoma after different types of cordectomy with transoral laser microsurgery[J]. Acta Otolaryngol, 2018, 138(8): 741-745. doi:10.1080/00016489.2018.1439592.
[14] 王琦, 徐霖, 汪文斌, 等. 早期声门型喉癌CO2激光术后创面的动态观察[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(4): 289-293. doi:10.3760/cma.j.issn.1673-0860.2016.04.010. WANG Qi, XU Lin, WANG Wenbin, et al. Wound healing following laser cordectomy for early glottic carcinoma[J]. Chin J Otorhinolaryngol Head Neck Surg, 2016, 51(4): 289-293. doi:10.3760/cma.j.issn.1673-0860.2016.04.010.
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