Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (6): 132-137.doi: 10.6040/j.issn.1673-3770.0.2021.096

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Research progress of miRNA-29b involved in EMT-related signaling pathway regulation

WANG Junxin1,2,SUN Yan2   

  1. 1. College of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University / Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai 264000, Shandong, China
  • Published:2021-12-10

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Abstract: Epithelial-mesenchymal transition(EMT)is a biological process of epithelial cells transforming into mesenchymal cells, conferring the ability of cell metastasis and invasion. This process is closely related to the progression of organ fibrosis and tumors. MiRNA-29b is a small noncoding RNA closely related to the EMT process. By modulating TGF-β/Smad, PI3K/AKT, Wnt/β-catenin, and other signaling pathways, miRNA-29b mediates the development of type II and type III EMT, and then delays the process of organ fibrosis, regulates the invasion and metastasis of tumors. The targeted therapy of miRNA-29b is expected to provide a new perspective for the clinical diagnosis and treatment of organ fibrosis and tumor invasion and metastasis. The research status of miRNA-29b regulating the process of organ fibrosis and tumor invasion and metastasis through various EMT-related signaling pathways was reviewed in this study.

Key words: MiRNA-29b, Epithelial-mesenchymal transition, Organ fibrosis, Tumor invasion and metastasis, Signaling pathway

CLC Number: 

  • R762
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