嗅觉测试在轻度认知障碍患者早期诊断中的研究进展

doi:10.6040/j.issn.1673-3770.0.2023.134

Abstract

Abstract: Mild cognitive impairment(MCI)serves as a transitional state between the typical ageing process and the onset of Alzheimer's disease. Emerging research indicates that MCI patients exhibit pathological alterations such as olfactory bulb atrophy and neuronal loss. Moreover, the severity of these pathological changes correlates with the degree of cognitive impairment. Hence, olfactory testing holds potential as a supplementary tool for MCI screening. Despite being in its nascent stages in China, research on early MCI diagnosis through olfactory tests is gaining momentum. In this study, we conduct a comprehensive review of pertinent literature, encompassing olfactory function, test content, characteristics, and current applications. Our aim is to furnish healthcare practitioners with insights into selecting suitable olfactory test instruments to enhance the early detection rate of MCI.

Key words: Mild cognitive impairment, Olfactory, Olfactory test instruments, Bulb atrophy, Neuronal loss

CLC Number:

R765

ZHOU Chunyi, HU Hui, ZHANG Ailin, WANG Yuncui. Advancements in olfactory testing for early diagnosis of mild cognitive impairment in patients[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 119-125.

References

[1] Geneva: World Health Organization. Global status report on the public health response to dementia [EB/OL].(2022-10-15)[2023-04-07].https://apps.who.int/iris/handle/10665/344701
[2] Petersen RC. Early diagnosis of Alzheimer's disease: is MCI too late?[J]. Curr Alzheimer Res, 2009, 6(4): 324-330. doi:10.2174/156720509788929237
[3] 任汝静, 殷鹏, 王志会, 等. 中国阿尔茨海默病报告2021[J]. 诊断学理论与实践, 2021, 20(4): 317-337. doi: 10.16150/j.1671-2870.2021.04.001 REN Rujing, YIN Peng, WANG Zhihui, et al. China Alzheimer's disease report 2021[J]. Journal of Diagnostics Concepts & Practice, 2021, 20(4): 317-337. doi: 10.16150/j.1671-2870.2021.04.001
[4] Brai E, Tonacci A, Brugada-Ramentol V, et al. Intercepting dementia: awareness and innovation as key tools[J]. Front Aging Neurosci, 2021, 13: 730727. doi:10.3389/fnagi.2021.730727
[5] Brai E, Hummel T, Alberi L. Smell, an underrated early biomarker for brain aging[J]. Front Neurosci, 2020, 14: 792. doi:10.3389/fnins.2020.00792
[6] Morrison C, Rabipour S, Taler V, et al. Visual event-related potentials in mild cognitive impairment and alzheimer's disease: a literature review[J]. Curr Alzheimer Res, 2019, 16(1): 67-89. doi:10.2174/1567205015666181022101036
[7] Olofsson JK, Larsson M, Roa C, et al. Interaction between odor identification deficit and APOE4 predicts 6-year cognitive decline in elderly individuals[J]. Behav Genet, 2020, 50(1): 3-13. doi:10.1007/s10519-019-09980-9
[8] Devanand DP, Michaels-Marston KS, Liu X, et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up[J]. Am J Psychiatry, 2000, 157(9): 1399-1405. doi:10.1176/appi.ajp.157.9.1399
[9] Dintica CS, Marseglia A, Rizzuto D, et al. Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain[J]. Neurology, 2019, 92(7): e700-e709. doi:10.1212/WNL.0000000000006919
[10] 李丹, 陈腾宇, 黄演芬, 等. 国内嗅觉障碍相关研究: 基于Citespace的可视化分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 40-48. doi: 10.6040/j.issn.1673-3770.0.2021.349 LI Dan, CHEN Tengyu, HUANG Yanfen, et al. Research in the field of olfactory disorders in China—an analysis based on Citespace[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 40-48. doi: 10.6040/j.issn.1673-3770.0.2021.349
[11] 刘庆华, 李志春. 嗅感觉神经元的再生调控及与嗅觉障碍的关系[J]. 山东大学耳鼻喉眼学报, 2006, 20(2): 179-182. doi: 10.3969/j.issn.1673-3770.2006.02.028 LIU Qinghua, LI Zhichun. Regeneration regulation of olfactory sensory neurons and its relationship with olfactory dysfunction[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2006, 20(2): 179-182. doi: 10.3969/j.issn.1673-3770.2006.02.028
[12] Rombaux P, Duprez T, Hummel T. Olfactory bulb volume in the clinical assessment of olfactory dysfunction[J]. Rhinology, 2009, 47(1): 3-9
[13] Han P, Zang Y, Akshita J, et al. Magnetic resonance imaging of human olfactory dysfunction[J]. Brain Topogr, 2019, 32: 987-997. doi:10.1007/s10548-019-00729-5
[14] Trimmer C, Mainland JD. Simplifying the odor landscape[J]. Chem Senses, 2017, 42(3): 177-179. doi:10.1093/chemse/bjx002
[15] Kondo K, Kikuta S, Ueha R, et al. Age-related olfactory dysfunction: epidemiology, pathophysiology, and clinical management[J]. Front Aging Neurosci, 2020, 12: 208. doi:10.3389/fnagi.2020.00208
[16] Roalf DR, Moberg MJ, Turetsky BI, et al. A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment[J]. J Neurol Neurosurg Psychiatry, 2017, 88(3): 226-232. doi:10.1136/jnnp-2016-314638
[17] Murphy C. Olfactory and other sensory impairments in Alzheimer disease[J]. Nat Rev Neurol, 2019, 15(1): 11-24. doi:10.1038/s41582-018-0097-5
[18] Devanand DP, Michaels-Marston KS, Liu X, et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up[J]. Am J Psychiatry, 2000, 157(9): 1399-1405. doi:10.1176/appi.ajp.157.9.1399
[19] Rahayel S, Frasnelli J, Joubert S. The effect of Alzheimer's disease and Parkinson's disease on olfaction: a meta-analysis[J]. Behav Brain Res, 2012, 231(1): 60-74. doi:10.1016/j.bbr.2012.02.047
[20] Makizako M, Makizako H, Doi T, et al. Olfactory identification and cognitive performance in community-dwelling older adults with mild cognitive impairment[J]. Chem Senses, 2014, 39(1): 39-46. doi:10.1093/chemse/bjt052
[21] Mi Y, Ma XJ, Du S, et al. Olfactory function changes and the predictive performance of the Chinese Smell Identification Test in patients with mild cognitive impairment and Alzheimer's disease[J]. Front Aging Neurosci, 2023, 15: 1068708. doi:10.3389/fnagi.2023.1068708
[22] Hummel T, Pfetzing U, Lötsch J. A short olfactory test based on the identification of three odors[J]. J Neurol, 2010, 257(8): 1316-1321. doi:10.1007/s00415-010-5516-5
[23] Jung HJ, Shin IS, Lee JE. Olfactory function in mild cognitive impairment and Alzheimer's disease: a meta-analysis[J]. Laryngoscope, 2019, 129(2): 362-369. doi:10.1002/lary.27399
[24] 李楠, 徐心. 嗅觉障碍及其临床检测方法[J]. 中华临床医师杂志(电子版), 2013(21): 9759-9761. doi:10.3877/cma.j.issn.1674-0785.2013.21.087
[25] Scherfler C, Schocke MF, Seppi K, et al. Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease[J]. Brain, 2006, 129(Pt 2): 538-542. doi:10.1093/brain/awh674
[26] Invitto S, Piraino G, Ciccarese V, et al. Potential role of OERP as early marker of mild cognitive impairment[J]. Front Aging Neurosci, 2018, 10: 272. doi:10.3389/fnagi.2018.00272
[27] Morgan CD, Murphy C. Olfactory event-related potentials in Alzheimer's disease[J]. J Int Neuropsychol Soc, 2002, 8(6): 753-763. doi:10.1017/s1355617702860039
[28] Li W, Howard JD, Gottfried JA. Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer's disease[J]. Brain, 2010, 133(9): 2714-2726. doi:10.1093/brain/awq209
[29] 陈红, 吴亚琳, 龙淼淼, 等. 嗅觉功能磁共振成像评估对非痴呆老年人认知下降的预测价值[J]. 中国医学影像学杂志, 2021, 29(10): 961-967. doi:10.3969/j.issn.1005-5185.2021.10.002
[30] Doty RL, Shaman P, Dann M. Development of the university of Pennsylvania smell identification test: a standardized microencapsulated test of olfactory function[J]. Physiol Behav, 1984, 32(3): 489-502. doi:10.1016/0031-9384(84)90269-5
[31] Doty RL, Shaman P, Kimmelman CP, et al. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic[J]. Laryngoscope, 1984, 94(2 Pt 1): 176-178. doi:10.1288/00005537-198402000-00004
[32] 杨斯闵, 李璐迪, 曹月, 等. 基于3D脑结构MRI定量分析对轻度认知障碍及阿尔茨海默病患者嗅觉皮层的研究[J]. 磁共振成像, 2023, 14(1): 20-24. doi: 10.12015/issn.1674-8034.2023.01.004 YANG Simin, LI Ludi, CAO Yue, et al. The study of structural magnetic resonance imaging on gray matter volumes of olfactory brain regions in patients with mild cognitive impairment and Alzheimer's disease[J]. Chinese Journal of Magnetic Resonance Imaging, 2023, 14(1): 20-24. doi: 10.12015/issn.1674-8034.2023.01.004
[33] Vasavada MM, Wang JL, Eslinger PJ, et al. Olfactory cortex degeneration in Alzheimer's disease and mild cognitive impairment[J]. J Alzheimers Dis, 2015, 45(3): 947-958. doi:10.3233/JAD-141947
[34] Vassilaki M, Christianson TJ, Mielke MM, et al. Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals[J]. Ann Neurol, 2017, 81(6): 871-882. doi:10.1002/ana.24960
[35] Devanand DP, Lee S, Luchsinger JA, et al. Intact global cognitive and olfactory ability predicts lack of transition to dementia[J]. Alzheimers Dement, 2020, 16(2): 326-334. doi:10.1016/j.jalz.2019.08.200
[36] Kobal G, Hummel T, Sekinger B, et al. “Sniffin' sticks”: screening of olfactory performance[J]. Rhinology, 1996, 34(4): 222-226
[37] Hummel T, Kobal G, Gudziol H, et al. Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3, 000 subjects[J]. Eur Arch Otorhinolaryngol, 2007, 264(3): 237-243. doi:10.1007/s00405-006-0173-0
[38] Doorduijn AS, de van der Schueren MAE, van de Rest O, et al. Olfactory and gustatory functioning and food preferences of patients with Alzheimer's disease and mild cognitive impairment compared to controls: the NUDAD project[J]. J Neurol, 2020, 267(1): 144-152. doi:10.1007/s00415-019-09561-0
[39] 郭文静, 赵傲楠, 闫艺, 等. 嗅觉检测对中国阿尔茨海默病和轻度认知功能障碍患者的诊断价值[J]. 中国医药导报, 2023, 20(2): 60-64. doi: 10.20047/j.issn1673-7210.2023.02.13 GUO Wenjing, ZHAO Aonan, YAN Yi, et al. Diagnostic value of olfactory tests in patients with Alzheimer's disease and mild cognitive impairment in China[J]. China Medical Herald, 2023, 20(2): 60-64. doi: 10.20047/j.issn1673-7210.2023.02.13
[40] Dong Y, Wang Y, Liu K, et al. Dementia screening in rural-dwelling Chinese older adults: the utility of a smell test and the self-rated AD8[J]. J Am Geriatr Soc, 2022, 70(4): 1106-1116. doi:10.1111/jgs.17586
[41] Feng G, Zhuang Y, Yao FS, et al. Development of the Chinese smell identification test[J]. Chem Senses, 2019, 44(3): 189-195. doi:10.1093/chemse/bjz006
[42] Tu LH, Wang ZJ, Lv XZ, et al. Characteristics of odor identification and hedonics and their association with piriform cortex-based resting-state functional connectivity in amnestic mild cognitive impairment[J]. J Alzheimers Dis, 2023, 94(1): 247-258. doi:10.3233/JAD-221163
[43] Wu XQ, Geng Z, Zhou SS, et al. Brain structural correlates of odor identification in mild cognitive impairment and Alzheimer's disease revealed by magnetic resonance imaging and a Chinese olfactory identification test[J]. Front Neurosci, 2019, 13: 842. doi:10.3389/fnins.2019.00842
[44] 梁维, 王岚, 耿皓, 等. 中国简短嗅觉识别测试在早期阿尔茨海默病筛查中的应用[J]. 中国心理卫生杂志, 2023, 37(5): 380-387. doi: 10.3969/j.issn.1000-6729.2023.05.004 LIANG Wei, WANG Lan, GENG Hao, et al. Application of the Brief Chinese Smell Identification in early Alzheimer's disease screening[J]. Chinese Mental Health Journal, 2023, 37(5): 380-387. doi: 10.3969/j.issn.1000-6729.2023.05.004
[45] 米颜. 嗅觉识别功能评估在轻度认知障碍筛查中的应用[D]. 延安: 延安大学, 2022
[46] Hagemeier J, Woodward MR, Rafique UA, et al. Odor identification deficit in mild cognitive impairment and Alzheimer's disease is associated with hippocampal and deep gray matter atrophy[J]. Psychiatry Res Neuroimaging, 2016, 255: 87-93. doi:10.1016/j.pscychresns.2016.08.003
[47] Nussbaum JM, Seward ME, Bloom GS. Alzheimer disease: a tale of two prions[J]. Prion, 2013, 7(1): 14-19. doi:10.4161/pri.22118
[48] 王治国, 战莹, 张国旭, 等. β-淀粉样蛋白沉积与轻度认知障碍患者认知功能的相关性[J]. 中华老年多器官疾病杂志, 2020, 19(5): 331-335. doi: 10.11915/j.issn.1671-5403.2020.05.023 WANG Zhiguo, ZHAN Ying, ZHANG Guoxu, et al. Correlation of β-amyloid deposition with cognitive function in mild cognitive impairment patients[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2020, 19(5): 331-335. doi: 10.11915/j.issn.1671-5403.2020.05.023
[49] Murphy C. Olfactory and other sensory impairments in Alzheimer disease[J]. Nat Rev Neurol, 2019, 15(1): 11-24. doi:10.1038/s41582-018-0097-5
[50] Hagemeier J, Woodward MR, Rafique UA, et al. Odor identification deficit in mild cognitive impairment and Alzheimer's disease is associated with hippocampal and deep gray matter atrophy[J]. Psychiatry Res Neuroimaging, 2016, 255: 87-93. doi:10.1016/j.pscychresns.2016.08.003
[51] Jobin B, Boller B, Frasnelli J. Volumetry of olfactory structures in mild cognitive impairment and alzheimer's disease: a systematic review and a meta-analysis[J]. Brain Sci, 2021, 11(8): 1010. doi:10.3390/brainsci11081010
[52] Pinto TCC, Machado L, Bulgacov TM, et al. Is the Montreal Cognitive Assessment(MoCA)screening superior to the Mini-Mental State Examination(MMSE)in the detection of mild cognitive impairment(MCI)and Alzheimer's Disease(AD)in the elderly?[J]. Int Psychogeriatr, 2019, 31(4): 491-504. doi:10.1017/S1041610218001370
[53] Yoo SH, Woo SW, Shin MJ, et al. Diagnosis of mild cognitive impairment using cognitive tasks: a functional near-infrared spectroscopy study[J]. Curr Alzheimer Res, 2020, 17(13): 1145-1160. doi:10.2174/1567205018666210212154941
[54] 魏霞霞, 郝志梅, 陈玲, 等. 简版CSI-D与MMSE在我国中老年人痴呆筛查中的应用效果比较研究[J]. 中国全科医学, 2022, 25(31): 3866-3871. doi: 10.12114/j.issn.1007-9572.2022.0272 WEI Xiaxia, HAO Zhimei, CHEN Ling, et al. Comparison of the brief CSI-D and MMSE scales in screening for dementia in middle-aged and elderly Chinese people[J]. Chinese General Practice, 2022, 25(31): 3866-3871. doi: 10.12114/j.issn.1007-9572.2022.0272
[55] Velayudhan L, Gasper A, Pritchard M, et al. Pattern of smell identification impairment in Alzheimer's disease[J]. J Alzheimers Dis, 2015, 46(2): 381-387. doi:10.3233/JAD-142838
[56] Quarmley M, Moberg PJ, Mechanic-Hamilton D, et al. Odor identification screening improves diagnostic classification in incipient alzheimer's disease[J]. J Alzheimers Dis, 2017, 55(4): 1497-1507. doi:10.3233/JAD-160842
[57] Park H, Kim H, Kim S, et al. The association between olfactory function and cognitive impairment in older persons with cognitive impairments: a cross-sectional study[J]. Healthcare(Basel), 2021, 9(4): 399. doi:10.3390/healthcare9040399

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