Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (1): 30-34.doi: 10.6040/j.issn.1673-3770.0.2021.464

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Respiratory epithelial adenomatoid hamartoma in the nasal cavity: a case report and literature review

CEN Yanfang1, WU Yingfang2, HU Yuying3, KONG Zhe2, LIANG Yan2, LI Xingya1, XIA Jiyan2   

  1. 1. The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510403, Guangdong, China;
    2. Department of Otolaryngology Head and Neck, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China;
    3. Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510006, Guangdong, China
  • Published:2023-02-06

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Abstract: Objective To explore the clinical, imaging, pathological features and treatment of nasal respiratory epithelial adenomatous hamartoma(REAH). Methods We report the case of a patient with REAH in the nasal cavity and review prior cases of REAH in the nasal cavity published in the literature. Results The most frequent symptoms of REAH in the nasal cavity are nasal obstruction and olfactory impairment. In terms of imaging, olfactory cleft widening greater than 10 mm on computed tomography is characteristic of REAH. The diagnosis of REAH relies mainly on pathology; this malformationis characterized by a prominent glandular proliferation lined by ciliated respiratory epithelial cells. Conclusion The clinical symptoms of REAH are nonspecific. Therefore,imaging and histopathological examinations are especially important for its early diagnosis. Endoscopic resection is the treatment of choice for REAH.

Key words: Respiratory epithelial adenomatoid hamartoma, Nasal Cavity, Hamartoma, Olfactory cleft, Pathological biopsy

CLC Number: 

  • R765.2
[1] Al-Musaileem N, Qazi IM, Bastaki JM, et al. An atypical presentation of a Respiratory Epithelial Adenomatoid Hamartoma, a case report[J]. Ann Med Surg(Lond),2019, 46: 27-30. doi:10.1016/j.amsu.2019.08.007
[2] Wenig BM, Heffner DK. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases[J]. Ann Otol Rhinol Laryngol,1995,104(8):639-645. doi:10.1177/000348949510400809
[3] Davison WL, Pearlman AN, Donatelli LA, et al. Respiratory epithelial adenomatoid hamartomas: An increasingly common diagnosis in the setting of nasal polyps[J]. American Journal of Rhinology & Allergy, 2016, 30(4):139. doi:10.2500/ajra.2016.30.4338
[4] Schertzer JS, Levy JM, Wise SK, et al. Is respiratory epithelial adenomatoid hamartoma related to central compartment atopic disease?[J]. Am J Rhinol Allergy,2020, 34(5): 610-617. doi:10.1177/1945892420914212
[5] Nguyen DT, Jankowski R, Bey A, et al. Respiratory epithelial adenomatoid hamartoma is frequent in olfactory cleft after nasalization[J]. Laryngoscope, 2020, 130(9): 2098-2104. doi:10.1002/lary.28298
[6] Flavin R, Russell J, Phelan E, et al. Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity: a case report[J]. International Journal of Pediatric Otorhinolaryngology, 2005, 69(1): 87-91. doi:10.1016/j.ijporl.2004.07.010
[7] 房高丽,朴颖实,于文玲,等. 鼻腔呼吸道上皮腺瘤样错构瘤临床和影像学分析[J]. 中国耳鼻咽喉头颈外科,2020,27(5):267-270. doi:10.16066/j.1672-7002.2020.05.009 FANG Gaoli, PIAO Yingshi, YU Wenling, et al. Clinical and imaging features of respiratory epithelial adenomatoidhamartoma in nasal cavity[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2020, 27(5):267-270. doi:10.16066/j.1672-7002.2020.05.009
[8] Rom D, Lee M, Chandraratnam E, et al. Respiratory epithelial adenomatoid hamartoma: an important differential of sinonasal masses[J]. Cureus,2018,10(4):e2495. doi:10.7759/cureus.2495
[9] 于倩倩,关鸽,张念凯,等. 鼻腔嗅裂区呼吸道上皮腺瘤样错构瘤的CT影像表现[J]. 山东大学耳鼻喉眼学报,2018,32(3):76-81. doi:10.6040/j.issn.1673-3770.0.2017.355 YU Qianqian, GUAN Ge, ZHANG Niankai, et al. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography[J]. Journal of Otolaryngology and Ophthalmology of Shandong University,2018, 32(3): 76-81. doi:10.6040/j.issn.1673-3770.0.2017.355
[10] Safi C, Li C, Tabaee A, et al. Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review[J]. International Forum of Allergy & Rhinology, 2019, 9(6): 674-680. doi:10.1002/alr.22298
[11] 张胜男, 姜彦, 于龙刚, 等. 鼻腔呼吸道上皮腺瘤样错构瘤临床特征分析[J].中华耳鼻咽喉头颈外科杂志, 2019, 54(5): 373-376. doi:10.3760/cma.j.issn.1673-0860.2019.05.011 ZHANG Shengnan, JIANG Yan, YU Longgang, et al. Analysis of clinical features of respiratory epithelial adenomatoid hamartoma in the nasal cavity[J]. Chinese journal of otorhinolaryngology head and neck surgery, 2019, 54(5): 373-376. doi:10.3760/cma.j.issn.1673-0860.2019.05.011
[12] Safi C, Li C, Tabaee A, et al. Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review[J]. Int Forum Allergy Rhinol, 2019, 9(6): 674-680. doi:10.1002/alr.22298
[13] Kumar SA, O'Meara C, Fredericks S, et al. Beware the respiratory epithelial adenomatoid hamartoma-a malignant masquerador[J]. J Surg Case Rep, 2021, 2021(2): b7. doi:10.1093/jscr/rjab007
[14] 向世凤,李必强,杨健,等. 鼻腔鼻窦少见良性肿瘤及类肿瘤样病变的CT和磁共振成像诊断[J]. 实用放射学杂志, 2020, 36(6): 880-884. doi:10.3969/j.issn.1002-1671.2020.06.007 XIANG Shifeng, LI Biqiang, YANG Jian, et al. CT and MRI diagnosis of rare benign tumors and tumor-like lesions in nasal cavity and sinus[J]. Journal Of Practical Radiology, 2020, 36(6): 880-884. doi:10.3969/j.issn.1002-1671.2020.06.007
[15] 周亚美,杨昕,刘文惠,等. 鼻窦CT测量在呼吸道上皮腺瘤样错构瘤术前诊断中应用[J]. 临床军医杂志, 2019, 47(12):1325-1328. doi:10.16680/j.1671-3826.2019.12.15 ZHOU Yamei, YANG Xin, LIU Wenhui, et al. Application of sinus CT measurement in preoperative diagnosis of respiratory epithelial adenomatoid hamartoma[J]. Clinical Journal Of Medical Officers, 2019, 47(12): 1325-1328. doi:10.16680/j.1671-3826.2019.12.15
[16] Shanbag R, Patil P, Rani SH, et al. Respiratory epithelial adenomatoid hamartoma(REAH)in the ofactory cleft: often masked by bilateral nasal polyps[J]. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 3): 2121-2126. doi:10.1007/s12070-018-1562-6
[17] Li R, Saluja K, Lin M, et al. Sinonasal hamartomas: from nasal chondromesenchymal hamartoma to respiratory epithelial adenomatoid hamartoma. Report of six cases and review of the literature[J]. Int J Surg Pathol, 2022:135139437. doi:10.1177/10668969211064211
[18] Agrawal SR, Joshi AA, Dhorje N, et al. Respiratory epithelial adenomatoid hamartoma: a diagnostic challenge in sinonasal lesions[J]. BMJ Case Rep, 2019, 12(8):e230082. doi:10.1136/bcr-2019-230082
[19] Patel DN, Koshkareva YA, Mcfarland M, et al. A case of respiratory epithelial adenomatoid hamartoma(REAH)in a patient with history of radiation exposure[J]. Case Reports in Otolaryngology, 2019: 1-3. doi:10.1155/2019/9473608
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