Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 39-45.doi: 10.6040/j.issn.1673-3770.0.2023.010

• Research Progress • Previous Articles    

Exploration of the relationship between laryngopharyngeal reflux and recurrent respiratory papilloma and its mechanism

ZHAO Jianing, CUI Yuanxin, WANG Dan, ZHAO Ming   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130022, Jilin, China
  • Published:2024-12-13

Abstract: Laryngopharyngeal reflux(LPR)has a non-negligible role in the development of laryngeal tumors as an independent risk factor. Recurrent respiratory papillomatosis(RRP)is a disease with a very high recurrence rate, mostly in the larynx, which is benign but can be cancerous. The main treatment remains surgery, and the application of drugs, such as interferon and cidofovir, can be used as adjuvant therapy. Some studies have found that anti-reflux treatment also controls its development, and several studies have shown that LPR may be a risk factor for recurrent respiratory papillomatosis. We review the relevant literature at home and abroad that introduce the current research progress in LPR and RRP and discuss the possible relationship between LPR and RRP and the possible role of LPR in the occurrence, development, and malignant transformation of RRP to provide a theoretical basis for the next in-depth exploration of the specific mechanism and provide clinicians with new ideas for the diagnosis and treatment of RRP.

Key words: Laryngopharyngeal reflux, Recurrent respiratory papillomatosis, Human papillomavirus, Pepsin

CLC Number: 

  • R766.5
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