Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2026, Vol. 40 ›› Issue (1): 120-126.doi: 10.6040/j.issn.1673-3770.0.2024.134

• Review • Previous Articles    

Research progress of histone deacetylase 2 in glucocorticoid resistance in chronic airway inflammatory diseases

DUAN Siyu1, XUE Jinmei2   

  1. 1. Second Clinical Medical School, Shanxi Medical University, Taiyuan 030001, Shanxi, China2. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital of Shanxi Medical University, Engineering Research Center of AI Intelligent Big Data Platform for Prevention, Treatment and Demonstration Application of Airway Allergy of Shanxi Province, Shanxi Key Laboratory of Rapid Diagnosis and Precision Treatment of Airway Allergic Diseases/Shanxi Airway Inflammatory Diseases Neuroimmunity Laboratory, Taiyuan 030001, Shanxi, China
  • Published:2026-02-13

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Abstract: Chronic airway inflammatory disease is a kind of heterogeneous disease affecting the upper and lower respiratory tracts and lung parenchyma. Glucocorticoid(GC)is one of the most commonly used anti-inflammatory drugs in the clinical treatment of these diseases. However, some patients with sufficient GC treatment have unsatisfactory efficacy, that is, the phenomenon of glucocorticoid resistance(GCR), increasing the difficulty in the treatment of these diseases. Therefore, elucidating the pathogenesis of GCR is the key to its prevention and treatment. In recent years, relevant studies have suggested that the decrease in histone deacetylase 2(HDAC2)expression level and activity reduces the ability of the glucocorticoid receptor α(GRα)to inhibit the expression of pro-inflammatory genes, leading to the occurrence of GCR. Furthermore, the decrease in HDAC2 expression and activity in chronic inflammatory diseases of the airways is the result of covalent modification of HDAC2, the increase of PI3Κ/Akt signaling pathway, and the activation of the STING pathway under the background of airway oxidative stress, which will provide a new theoretical basis and idea for recovering GC sensitivity in chronic inflammatory diseases of the airways.

Key words: Histone deacetylase 2, Chronic airway inflammatory disease, Glucocorticoid, Glucocorticoid resistance, Oxidative stress

CLC Number: 

  • R563.9
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