JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Apoptosis of epithelial cells in nasal polyps promoted by erythromycin

XU Sainan1, YANG Lei2   

  1. 1. Department of Eye, Ear, Nose and Throat, Wenzhou Third People′s Hospital, Wenzhou 325000, Zhejiang, China;2. Biotechique Center， Wenzhou Medical College, Wenzhou 325000, Zhejiang, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-02-25 Published:2006-02-25

Abstract: Objective： To study the effect of erythromycin on apoptosis in nasal polyps. Methods： Epithelial cells from 30 nasal polyps and 6 inferior turbinates were cultured in Dulbecco eagle and Ham F12(1:1), which were divided into two groups, one with erythromycin, and the other without. Apoptosis was detected by terminal deoxynucleotidyl transferasemediated dUTP nickendlabeling. Results： The apoptosis index (AI) of epithelial cells in nasal polyps after cultured for 1,3,5 days was (33.23±6.50)%,（38.21±7.22）% and （52.63±7.86）% respectively. The AI of epithelial cells in inferior turbinate was (31.02±5.60)%,（32.13±7.15）% and （39.64±7.48）% respectively. There was a significant difference between the two groups at day 5 after culture(P＜0.05). Conclusion： Erythromycin promotes apoptosis of epithelial cells from nasal polyps.

Key words: Nasal polyps, Endothelial cells, Erythromycin, Apoptosis

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