JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (4): 26-29.doi: 10.6040/j.issn.1673-3770.0.2016.032

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Study on single nucleotide polymorphisms of partial allergic rhinitis-associated haplotype module genes.

TENG Weiqiang1, CHEN Xiaoping2, ZHANG Yan2, ZHOU Enhui3, YAO Wenhao3, LI Li   

  1. 1. Department of Otolaryngology &Head and Neck Surgery, Shanghai Changzheng Hospital, Shanghai 200003, China;2. Department of Otolaryngology &Head and Neck Surgery, Gongli Hospital of Pudong Area, Shanghai 200135, China;3. Ningxia Medical University, Yinchuan 750004, Ningxia, China
  • Received:2016-01-24 Online:2016-08-16 Published:2016-08-16

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Abstract: Objective To detect whether there exist allergic rhinitis-associated hapoltype module genes(SDAD1, CXCL10, CXCL11 and EoBL)and single nucleotide polymorphisms(SNP)on chromosome as well as whether these genes affect on SNP. Methods The blood sample DNA of patients with allergic rhinitis in hereditary background group and distribution group was extracted, and gene sequencing was conducted following polymerase chain reaction(PCR)primer design, synthesis and amplification. Results A total of 46 sites were detected in both groups, of which 34 had mutations, with total mutation rate being 78.3%. And there was significant difference in the gene mutation of allergic rhinitis between hereditary background group(66.67%)and distribution group(78.57%)(P=0.58). Conclusion SDAD1, CXCL9, CSCL10 and CXCL11 genes are expressed successively on chromosome haplotype modules in patients with allergic rhinitis, and SNP is extensively distributed on allergic rhinitis-associated genes, including SDAD1, CXCL10, CXCL11 and EoBL, but hereditary factors have insignificant influence on these mutations.

Key words: Haplotype module genes, Single nucleotide polymorphisms, Allergic rhinitis

CLC Number: 

  • R765.21
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