JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (3): 55-59.doi: 10.6040/j.issn.1673-3770.0.2017.228

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Immunocompetence of nasal epithelial cells in allergic rhinitis.

SHA Jichao, ZHANG Ce, ZHU Dongdong   

  1. Department of Otolaryngology Head Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China
  • Received:2017-05-22 Online:2017-06-16 Published:2017-06-16

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Abstract: Although much is known about the imbalance of Th1/Th2 in allergic rhinitis(AR), the role of nasal epithelial cells as the first line of mucosal defense against inhaled pathogens remains undefined, despite the growing concern surrounding it. We now realize that epithelial cells recognize allergens through expression of pattern-recognition receptors and then mount the innate and adaptive immune responses. Therefore, epithelial cells are crucial in determining the outcome of allergen inhalation in AR. Here, we will review the literature on immunocompetence of nasal epithelial cells in AR.

Key words: Crosstalk, Allergic rhinitis, Nasal epithelial cells

CLC Number: 

  • R765.21
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