JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (4): 56-59.doi: 10.6040/j.issn.1673-3770.0.2016.257

Previous Articles     Next Articles

Clinical effect of focused ultrasound in combination with nasal spray hormone in treating allergic rhinitis.

ZANG Jian1, LIU Qian2, JIANG Xuejun   

  1. 1. Department of Otolaryngology, First Affiliated Hospital of Chinese Medical University, Shenyang 110001, Liaoning, China;2. Department of General Medicine, Shengjing Hospital, Chinese Medical University, Shenyang 110001, Liaoning, China
  • Received:2016-06-07 Online:2016-08-16 Published:2016-08-16

Abstract: Objective To observe the therapeutic effect of focused ultrasound and nasal spray hormone in treating allergic rhinitis under nasal endoscopy. Methods After focused ultrasound treatment, the patients with allergic rhinitis were randomly divided into A and B two groups. Group A continued to use small dose of nasal spray hormone for 3 months, while group B as the control group without using nasal spray hormone. We interviewed the patients respectively before and at the 3 months, 1 year and 2 years after surgery. The visual analogue scale(VAS)was recorded. Results Compared with baseline, the VAS scores of the two groups were both significantly decreased(P<0.05)at postoperative 3 months, 1 year and 2 years. but with the time extension, the scores of group B were statistically significantly increased(P<0.05); No obvious difference was found at group A within 1 years follow-up, the difference was statistically significant at 2 year follow-up. Between group A and B there were statistically significant difference scores at postoperative 1 year and 2 years follow-up, the score of group A was lower. Conclusion For allergic rhinitis, the efficacy of focused ultrasound is significant, but it is decreased over time. If with postoperative small dose of nasal spray hormone, the long-term treatment effect is significantly improved.

Key words: Allergic rhinitis, Focused ultrasound, Surgical treatment, operative

CLC Number: 

  • R765.21
[1] 中华耳鼻咽喉头颈外科杂志编委会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2009年,武夷山)[J].中华耳鼻咽喉头颈外科杂志,2009,44:977-978.
[2] Wu A W, Ting J Y. Indications for surgery in refractory rhinitis[J]. Curr Allergy Asthma Rep, 2014, 14(2):414.
[3] Seidman M D, Gurgel R K, Lin S Y, et al. Clinical practice guideline: allergic rhinitis executive summary[J]. Otolaryngol Head Neck Surg, 2015, 152(2):197-206.
[4] Wei H, Zhang Y, Shi L, et al. Higher dosage of HIFU treatment may lead to higher and longer efficacy for moderate to severe perennial allergic rhinitis[J]. Inter J Med Sci, 2013, 10(13):1914-1920.
[5] Wei H, Shi L, Zhang J, et al. High-intensity focused ultrasound leads to histopathologic changes of the inferior turbinate mucosa with allergic inflammation[J]. Ultrasound Med Biol, 2014, 40(10):2425-2430.
[6] Feng G F, Han Z L, Wang F, et al. Comparison of high-intensity focused ultrasound therapy under nasal endoscopy guidance versus first-line drug treatment in patients with persistent allergic rhinitis[J]. Gene Molecular Res, 2015, 14(3):9865-9871.
[7] 张静茹,魏宏权,夏炎,等.聚焦超声治疗变应性鼻炎患者的2年随访分析[J].中国医科大学学报,2014,43(3):253-264. ZHANG Jingru, WEI Hongquan, XIA Yan, et al. Focused ultrasound treatment of patients with allergic rhinitis two-year follow-up analysis[J]. J China Med Univ, 2014, 43(3):253-264.
[8] 韩继波,孔勇刚,许昱,等.射频消融和高能聚焦超声术治疗持续性变应性鼻炎疗效对比[J].临床耳鼻咽喉头颈外科杂志,2011,25(8):349-351. HAN Jibo, KONG Yonggang, XU Yu, et al. Clinical observation and comparison on radiofrequency ablation and focused ultrasound in treatment of perennial allergic rhinitis[J]. J Clin Otorhinolaryngol Head Neck Surgery, 2011, 25(8):349-351.
[9] Brozek J L, Bousquet J, Baena-Cagnani C E, et al. Allergic rhinitis and its impact on asthma(ARIA)guidelines: 2010 revision[J]. J Allergy Clin Immunol, 2010, 126:466-476.
[10] Ciprandi G, Mora F, Cassano M, et al. Visual analog scale(Vas)and nasal obstruction in persistent allergic rhinitis[J]. Otolaryngol Head Neck Surgery, 2009, 141(4):527-529.
[11] 石崧,周水淼.鼻后下神经下鼻甲支的应用解剖学研究[J].中国耳鼻咽喉头颈外科,2006,13(7):491-492. SHI Song, ZHOU Shuimiao. The study of the inferior turbinate branch of the posterior inferior nasal nerve[J]. Chin Arch Otolaryngol Head Neck Surgery, 2006, 13(7):491-492.
[12] Bousquet P J, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines[J]. Allergy, 2007, 62(4):367-372.
[13] Bousquet J, Vignola A M, Chanez P, et al. Airways remodelling in asthma: no doubt, no more?[J]. Inter Arch Allergy Immunol, 1995, 107(1-3):211-214.
[14] Bousquet J, Jacot W, Vignola A M, et al. Allergic rhinitis: a disease remodeling the upper airways?[J]. J Allergy Clin Immunol, 2004, 113(1):43-49.
[15] 佘文煜,董震.实验性变应性鼻炎鼻黏膜组织重塑的特点[J].中华耳鼻咽喉头颈外科杂志,2006,41(1):48-52.
[16] Nakaya M, Dohi M, Okunishi K, et al. Prolonged allergen challenge in murine nasal allergic rhinitis: nasal airway remodeling and adaptation of nasal airway responsiveness[J]. Laryngoscope, 2007, 117(8):881- 885.
[17] Constantino Gde T, Mello Jr J F. Remodeling of the lower and upper airways[J]. Braz J Otorhinolaryngol, 2009, 75(1):151-156.
[18] Hirshoren N, Kohan M, Assayag M, et al. Extra domain-A fibronectin is necessary for the development of nasal remodeling in chronic allergen-induced rhinitis[J]. Ann Allergy, Asthma Immunol, 2013, 110(5):322-327.
[19] Kim T H, Lee J Y, Lee H M, et al. Remodelling of nasal mucosa in mild and severe persistent allergic rhinitis with special reference to the distribution of collagen, proteoglycans, and lymphatic vessels[J]. Clin Expe Allergy, 2010, 40(12):1742-1754.
[20] Trifilieff A, EI-Hashim A, Bertrand C. Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment[J]. Am J Physiol Lung Cell Mol Physiol, 2000, 279(6):L1120-1128.
[21] Vanacker N J, Palmans E, Kips J C, et al. Fluticasone inhibits but does not reverse allergen-induced structural airway changes[J]. Am J Respir Crit Care Med, 2001, 163:674-679.
[22] Chhabra N, Houser S M. The surgical management of allergic Rhinitis[J]. Otolaryngol Clin North Am, 2011, 44(3):779-795.
[23] 林欣然,张龙城.聚焦超声治疗变应性鼻炎研究进展[J].临床耳鼻咽喉头颈外科杂志,2012,26(14):670-672.
[24] She W, Takeuchi K, Suzuki S, et al. Remodeling of nasal mucosa by allergen exposure in guinea pigs is suppressed by steroid and pranlukast[J]. Rhinol, 2009, 47(2):199-206.
[25] Miller M, Cho J Y, McEIwain K, et al. Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice[J]. Am J Physiol Lung Cell Mol Physiol, 2006, 290(1):L162-169.
[1] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[2] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[3] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[4] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[5] WU Xiangping. Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 68-72.
[6] LI Song, WANG Zonggui, YANG Jingpu, ZHANG Zhuping. Progress of transnasal endoscopic vidian neurectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 72-76.
[7] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[8] WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.
[9] SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 9-12.
[10] LIU Jing. Treatment of allergic rhinitis using syndrome differentiation based on the concept of “holism” in TCM. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 28-30.
[11] CHENG Lei, QIAN Junjun, TIAN Huiqin. Research progresses on allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 1-3.
[12] XU Yu, TAO Zezhang. Pharmacotherapeutic strategies for allergic rhinitis:Ithe importance of individualization and normalization. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 4-8.
[13] LI Lizhu, WU Qing, YI Xin, TIAN Li. Research progress on the animal model of allergic rhinitis in traditional Chinese medicine. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 60-63.
[14] SHA Jichao, ZHANG Ce, ZHU Dongdong. Immunocompetence of nasal epithelial cells in allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 55-59.
[15] XIANG Nan, ZHANG Qinxiu. Experience of professor Zhang Qinxiu in the treatment of perennial allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 100-102.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!