JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 63-67.doi: 10.6040/j.issn.1673-3770.0.2017.547

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Changes in nasal secretion of ECP, EGF and IL-6 in patients with chronic sinusitis before and after endoscopic sinus surgery and their clinical significance

ZHANG Wei1, ZENG Yuhan2, YU Xiansong1   

  1. Department of Otolaryngology, Sixth Peoples Hospital of Chongqing, Chongqing 400060, China;
  • Received:2017-12-26 Online:2018-05-20 Published:2018-05-20

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Abstract: Objective To investigate changes in eosinophil cationic protein(ECP), epidermal growth factor(EGF)and interleukin-6 in nasal secretions of patients with chronic rhinosinusitis(CRS)and nasal polyps before and after endoscopic sinus surgery, analyzing their significance for postoperative wound healing. Methods A total of 163 CRS patients with nasal polyps who underwent endoscopic sinus surgery were enrolled in this study. Nasal secretions was collected 1, 6, and 12 weeks after operation. The concentrations of ECP, EGF and IL-6 were detected by enzyme-linked immunosorbent assay. Results Compared with a control group, preoperative ECP, EGF, and IL-6 levels were significantly increased in the patients(P<0.001). The levels of ECP, EGF and IL-6 at 1 week postoperative were significantly lower than those in the control group(P<0.05). The levels of ECP, EGF and IL-6 at 6 weeks postoperative were significantly higher than those in the control group, and also higher than the preoperative and 1-week postoperative levels(P<0.05). The levels of ECP, EGF and IL-6 at 12 weeks postoperative were significantly lower than the preoperative levels and 6-week postoperative levels(P<0.05), significantly higher than the 1-week postoperative levels(P<0.05), and not significantly different from the preoperative levels(P>0.05). Linear regression analysis showed that preoperative ECP, EGF and IL-6 levels affected the healing of the surgical cavity 6 weeks and 12 weeks postoperatively(P<0.05). Conclusion The levels of ECP, EEG and IL-6 were significantly increased in patients with CRS nasal polyps before operation, and the dynamic changes during postoperative wound healing may have been related to the postoperative epithelial repair process.

Key words: Sinusitis, chronic, Endoscopic surgical procedures, operative, Eosinophil cationic protein, Interleukin-6, Epidermal growth factor

CLC Number: 

  • R765.4
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