JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 63-67.doi: 10.6040/j.issn.1673-3770.0.2017.547

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Changes in nasal secretion of ECP, EGF and IL-6 in patients with chronic sinusitis before and after endoscopic sinus surgery and their clinical significance

ZHANG Wei1, ZENG Yuhan2, YU Xiansong1   

  1. Department of Otolaryngology, Sixth Peoples Hospital of Chongqing, Chongqing 400060, China;
  • Received:2017-12-26 Online:2018-05-20 Published:2018-05-20

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Abstract: Objective To investigate changes in eosinophil cationic protein(ECP), epidermal growth factor(EGF)and interleukin-6 in nasal secretions of patients with chronic rhinosinusitis(CRS)and nasal polyps before and after endoscopic sinus surgery, analyzing their significance for postoperative wound healing. Methods A total of 163 CRS patients with nasal polyps who underwent endoscopic sinus surgery were enrolled in this study. Nasal secretions was collected 1, 6, and 12 weeks after operation. The concentrations of ECP, EGF and IL-6 were detected by enzyme-linked immunosorbent assay. Results Compared with a control group, preoperative ECP, EGF, and IL-6 levels were significantly increased in the patients(P<0.001). The levels of ECP, EGF and IL-6 at 1 week postoperative were significantly lower than those in the control group(P<0.05). The levels of ECP, EGF and IL-6 at 6 weeks postoperative were significantly higher than those in the control group, and also higher than the preoperative and 1-week postoperative levels(P<0.05). The levels of ECP, EGF and IL-6 at 12 weeks postoperative were significantly lower than the preoperative levels and 6-week postoperative levels(P<0.05), significantly higher than the 1-week postoperative levels(P<0.05), and not significantly different from the preoperative levels(P>0.05). Linear regression analysis showed that preoperative ECP, EGF and IL-6 levels affected the healing of the surgical cavity 6 weeks and 12 weeks postoperatively(P<0.05). Conclusion The levels of ECP, EEG and IL-6 were significantly increased in patients with CRS nasal polyps before operation, and the dynamic changes during postoperative wound healing may have been related to the postoperative epithelial repair process.

Key words: Sinusitis, chronic, Endoscopic surgical procedures, operative, Eosinophil cationic protein, Interleukin-6, Epidermal growth factor

CLC Number: 

  • R765.4
[1] 杨春, 孟粹达, 朱冬冬. 嗜酸粒细胞性慢性鼻-鼻窦炎研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2017,31(3):241-246. YANG Chun, MENG Chunda, ZHU Dongdong. Eosinophilic chronic rhinosinusitis [J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(3):241-246.
[2] 罗嘉龙,赵晓明. 血清IgG4抗体及嗜酸粒细胞阳离子蛋白在变应性鼻炎特异性免疫治疗过程中的应用及意义[J]. 临床耳鼻咽喉头颈外科杂志,2016, 30(13):1047-1048. LUO Jialong, ZHAO Xiaoming. Application and significance of serum IgG4 antibody and eosinophil cationic protein in specific immunotherapy of allergic rhinitis [J]. J Clin Otorhinolaryngol Head Neck Surg, 2016, 30(13): 1047-1048.
[3] 郭成兵, 吴曙辉, 朱红,等. 慢性鼻窦炎鼻内镜术后耳穴贴压辅助治疗的疗效观察[J]. 中国临床医学, 2016, 23(4):496-498. GUO Chengbing, WU Shuhui, ZHU Hong, et al. Chronic sinusitis after endoscopic surgery Auricular pressure assisted treatment of the efficacy of observation [J] Chin J Clin Med, 2016, 23(4):496-498.
[4] 罗燕. 中药鼻腔冲洗剂在鼻内镜鼻窦手术后应用的临床观察[J]. 湖北中医杂志, 2016, 38(2):47-48. LUO Yan. Chinese medicine nasal irrigator after endoscopic sinus surgery in the clinical observation [J]. Hubei Trad Chin Med, 2016, 38(2):47-48.
[5] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组. 慢性鼻-鼻窦炎诊断和治疗指南(2012年,昆明)[J]. 中国医刊, 2013, 48(11):92-94. Chinese Journal of Otorhinolaryngology Head and Neck Surgery Editorial Board of Ophthalmology. Guide for the diagnosis and treatment of chronic rhinosinusitis(2012, Kunming)[J]. Chin Med J, 2013, 48(11): 92-94.
[6] 李华斌, 张涵. 鼻用糖皮质激素与慢性鼻窦炎的治疗:EPOS 2012版意见[J]. 中国医学文摘(耳鼻咽喉科学), 2012, 27(4):207-210. LI Huabin, ZHANG Han. Treatment of nasal glucocorticoid and chronic sinusitis: EPOS 2012 version of the views [J]. Chin Med Abstracts: Otolaryngol, 2012, 27(4): 207-210.
[7] 杨勇,贺双美. 慢性鼻-鼻窦炎鼻内镜手术预后的影响因素分析[J]. 中外医学研究,2015,13(5):51-53. YANG Yong, HE Shuangmei. Chronic rhinosinusitis endoscopic surgery prognostic factors [J]. Chin Med Res, 2015, 13(5):51-53.
[8] 韦艳霞. 慢性鼻窦炎的发病机制及功能性鼻内窥镜术后综合治疗方法[J]. 临床医药文献杂志(电子版), 2016, 3(20):3991. WEI Yanxia. Pathogenesis of chronic sinusitis and functional endoscopic sinus surgery after comprehensive treatment[J]. Clin J Med Liter, 2016, 3(20):3991.
[9] 康厚墉, 杨玉成, 洪苏玲. 嗜酸性粒细胞阳离子蛋白在鼻部慢性炎症疾病中的分泌及意义[J]. 医学研究生学报, 2004, 17(6):315-318. KANG Huan, YANG Yucheng, HONG Suling. Secretion of eosinophil cationic protein in chronic inflammatory diseases of the nose [J]. J Med Postgradia, 2004, 17(6):315-318.
[10] 蔡雪倩. 嗜酸性粒细胞及中性粒细胞型慢性鼻-鼻窦炎患者临床对比研究[D]. 合肥:安徽医科大学, 2015.
[11] 章锦秀. 慢性鼻-鼻窦炎患者鼻分泌物中ECP的临床意义[D]. 广州:暨南大学, 2005.
[12] 李荣锐. 慢性鼻-鼻窦炎患者鼻黏膜组织重塑及骨质病理学观察[D]. 长春:吉林大学, 2013.
[13] 程海燕. IL-6受体融合蛋白的表达及初步鉴定[D]. 合肥:安徽医科大学, 2014.
[14] 肖志超. IL17、IL-8和IL-6在慢性鼻—鼻突炎中的表达及其意义[D]. 长沙:中南大学, 2013.
[15] 段晨, 徐欣, 史丽. 表皮生长因子与其受体在鼻息肉上皮中的表达[J]. 山东大学耳鼻喉眼学报, 2015, 29(2):31-35. DUAN Chen, XU Xin, SHI Li. Expression of epidermal growth factor and its receptor in the nasal polyp epithelium[J]. J Otorhinolaryngol Ophthalmol Shandong Univ, 2015, 29(2): 31-35.
[16] 王福娟, 李云川, 姜忠彩,等. 表皮生长因子受体和转化生长因子β1在慢性鼻窦炎黏膜上皮的表达[J]. 哈尔滨医科大学学报, 2015, 49(3):191-195. WANG Fujuan, LI Yunchuan, JIANG Zhongcai, et al. Expression of epidermal growth factor receptor and transforming growth factor beta 1 in mucosal epithelium of chronic sinusitis[J]. J Harbin Med Univ, 2015, 49(3):191-195.
[17] 黄维,杨秀海,漆一飞. 慢性鼻-鼻窦炎患者术后病变鼻黏膜转归研究[J]. 贵州医药,2014,38(2):121-122. HUANG Wei, YANG Xiuhai, QI Yifei. Chronic rhinosinusitis postoperative pathological changes of nasal mucosa [J]. Guizhou Med, 2014, 38(2):121-122.
[18] 杨璐瑜. 哮喘患者血清IL-6、TNF-α、IL-10表达变化与气道炎症的关系探讨[J]. 临床肺科杂志, 2013, 18(8):1389-1391. YANG Luyu. Expression of IL-6, TNF-αand IL-10 in asthmatic patients and their relationship with airway inflammation [J]. J Clin Pulm Med, 2013, 18(8):1389-1391.
[19] 段晨. EGF、EGFR与ERBB4在鼻息肉上皮中的表达[D]. 济南:山东大学, 2015.
[20] 李建兴, 杨党卫, 张伟强. 纳吸棉和膨胀海绵填塞对慢性鼻-鼻窦炎鼻内镜术后鼻腔黏膜转归的影响[J]. 中国医学工程, 2017,25(5):64-67. Li Jianxing, Yang Dangwei, Zhang Weiqiang. Effects of nanofiltration and expansive sponge fillings on nasal mucosa transformation after endoscopic sinus surgery for chronic rhino-sinusitis[J]. Chin Med Engin, 2017, 25(5):64-67.
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