JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 68-72.doi: 10.6040/j.issn.1673-3770.0.2018.044

Previous Articles     Next Articles

Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients

WU Xiangping   

  1. Department of Otorhinolaryngology, Dongguan Kanghua Hospital, Dongguan 523080, Guangdong, China
  • Received:2018-01-16 Online:2018-05-20 Published:2018-05-20

PDF (PC)

294

Abstract: Objective To analyze the influence of different patient management methods on the clinical effect and compliance to treatment with sublingual dermatophagoides farinae drops in patients with allergic rhinitis(AR). Methods One hundred and eighty patients with AR were randomly divided into a We-Media management Group(Group A, 90 patients)and a telephone management group(Group B, 90 patients). All patients were treated with sublingual immunotherapy(SLIT). In Group A, doctor-patient WeChat and/or QQ groups were formed. The doctor in charge acted as group leader, prepared monthly plans, sent to the patients SLIT-related information more than 3 times a week, and assessed patient reported outcome. In Group B, the patients were provided with on-the-spot demonstration and explanation and were followed up by telephone once every 3 month. We statistically analyzed dropout rates and the curative effect in the two groups at 1 year. Results The dropout rate in groups A and B was 13.3%(12/90)and 32.2%(29/90), respectively and the difference was statistically significant(χ2=9.128,P=0.003). The symptom scores before and after treatment were significantly different in both groups(P<0.05). There was no significant difference between Groups A and B before treatment(P>0.05), while the difference in the score of each symptom between the groups after treatment was significant(P<0.05). In Group A, the results were markedly effective in 15 patients(16.67%), effective in 49(54.44%), and ineffective in 26(28.89%), with a general effective rate of 71.11%(64/90). In Group B, the results were markedly effective in 13 patients(14.44%), effective in 26(28.89%), and ineffective in 51(56.67%), with a general effective rate of 43.33%(39/90). Conclusion The clinical effect and treatment compliance can be improved in patients with AR receiving SLIT by We-Media management.We-Media management is more advantageous especially in the long-term.

Key words: Allergic rhinitis, Sublingual immunotherapy, Patient management, We-Media, Clinical effect, Compliance

CLC Number: 

  • R765.4
[1] 中华医学会耳鼻咽喉头颈外科学分会鼻科学组, 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组. 变应性鼻炎诊断和治疗指南(2015 年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1):6-24.
[2] 邱前辉. 变应性鼻炎免疫治疗的现状和未来[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(1):9-12. QIU Qianhui. Current status and future of immunotherapy for allergic rhinitis[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(1):9-12.
[3] Roxbury CR, Lin SY. Efficacy and safety of subcutaneous and sublingual immunotherapy for allergic rhinoconjunctivitis and asthma[J]. Otolaryngol Clin North Am, 2017, 50(6):1111-1119.
[4] 程雷. 特异性免疫治疗是变应性鼻炎的一线疗法[J]. 山东大学耳鼻喉眼学报, 2016, 30(4):1-2. CHENG Lei. Allergen-specific immunotherapy as the first-line treatment for allergic rhinitis[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(4):1-2.
[5] Cox LS. Sublingual immunotherapy for allergic rhinitis: is 2-year treatment sufficient for long-term benefit?[J]. JAMA, 2017, 317(6):591-593.
[6] Schäfer U, Kienle-Gogolok A, Hadler M, et al. Treatment satisfaction during sublingual immunotherapy with a five-grass pollen tablet for allergic rhinoconjunctivitis: a prospective, non-interventional study[J]. Drugs Real World Outcomes, 2017, 4(2):109-117.
[7] Edwards TS, Wise SK. Clinical Applications of Sublingual Immunotherapy[J]. Otolaryngol Clin North Am, 2017, 50(6):1121-1134.
[8] 韩亮, 尤权杰, 李志, 等. 舌下免疫治疗变应性鼻炎满2年终止1年的疗效分析[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(7):497-500. HAN Liang, YOU Quanjie, LI Zhi, et al. Evaluation of efficacy of 1 year after completing the 2-year specific sublingual immunotherapy treatment course in allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2017, 52(7):497-500.
[9] Egert-Schmidt A, Martin E, Mueller J, et al. Patients' compliance towards high -dose hypoallergenic and unmodified SCIT treatment schedules is superior to sublingual immunotherapy[J]. Allergy, 2011, 66(Suppl 94): 628-629.
[10] Wang T, Li Y, Wang F, et al. Nonadherence to sublingual immunotherapy in allergic rhinitis: a real-life analysis[J]. Int Forum Allergy Rhinol, 2017, 7(4):389-392.
[11] 崔珑, 王智楠, 徐忠强. 电话随访对粉尘螨滴剂舌下脱敏治疗变应性鼻炎依从性的评价[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(8):364-366. CUI Long, WANG Zhinan, XU Zhiqiang. The analyse of telephone follow-up affecting the compliance of sublingual desensitization treatment to allergic rhinitis patients[J]. J Clin Otorhinolaryngol Head Neck Surg, 2011, 25(8):364-366.
[12] 张严文, 程雷. 舌下免疫治疗的临床现状及问题[J]. 中国中西医结合耳鼻咽喉科杂志, 2017, 25(3):161-163, 173.
[13] Marogna M, Spadolini I, Massolo A, et al. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study [J]. J Allergy Clin Immunol, 2010, 126(5):969-975.
[1] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[2] MENG Lixin, LI Jian, WEI Shanwen. Insertion of microtubules in tympanic membrane for the treatment of middle ear atelectasis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 61-65.
[3] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[4] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[5] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[6] GAO Jinliang, NIAN Wanqing, LI Shuo. Evaluation of the clinical curative effect of nose surgery in combination with nasal corticosteroids in [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 38-42.
[7] LI Song, WANG Zonggui, YANG Jingpu, ZHANG Zhuping. Progress of transnasal endoscopic vidian neurectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 72-76.
[8] ZHOU Xueyi, LI Yiming, WANG Meiju, ZHANG Yuanyuan, ZHANG Lizhuo. Clinical observation of 25-gauge minimally invasive vitreous retinal surgery for treatment of rhegmatogenous retinal detachment. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 92-94.
[9] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[10] WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.
[11] ZHU Xinhua. Clinical applicationof rush immunotherapy for allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 13-17.
[12] SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 9-12.
[13] LIU Jing. Treatment of allergic rhinitis using syndrome differentiation based on the concept of “holism” in TCM. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 28-30.
[14] CHENG Lei, QIAN Junjun, TIAN Huiqin. Research progresses on allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 1-3.
[15] XU Yu， TAO Zezhang. Pharmacotherapeutic strategies for allergic rhinitis:Ithe importance of individualization and normalization. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 4-8.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd