Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 126-129.doi: 10.6040/j.issn.1673-3770.0.2018.268

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Role of miRNAs in inner ear development and apoptosis or regeneration of auditory hair cells

XIE Yi, HAN Fengchan   

  1. Shandong Provincial Key Laboratory of Medical and Otological Genetic Diseases, Binzhou Medical University, Yantai 264003, Shandong, China
  • Published:2019-03-28

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Abstract: MicroRNAs are a class of small noncoding RNAs that are involved in cell differentiation, proliferation, apoptosis, and metabolic processes via regulation of post-transcriptional mechanisms. In recent years, many studies have revealed the importance of miRNAs for the development of the inner ear in vertebrates, and preventing apoptosis and promoting regeneration of the auditory hair cells. Regulation of miRNAs may provide novel strategies to study the mechanism of hearing impairment and treat hearing disorders.

Key words: miRNAs, Inner ear, Apoptosis, Regeneration

CLC Number: 

  • R764.43
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