Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (2): 125-130.doi: 10.6040/j.issn.1673-3770.0.2020.196

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Advances in understanding the roles of monocarboxylate transporters in head and neck squamous cell carcinoma

MA Xiaoyu, BIAN XiaominOverview,YU DanGuidance   

  1. Department of Otolaryngology & Head and Neck Surgery, The second hospital, Jilin University, Changchun 130041, Jilin, China
  • Published:2021-04-20

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Abstract: The family of monocarboxylate transporters(MCTs)is involved in regulating tumor metabolism. Specifically, such proteins play a role in transporting lactic acid, pyruvate, ketone bodies, and other metabolites in cells. Various MCT isoforms are highly-expressed across different tumor cells. Family members MCT1 and MCT4 in conjunction with associated chaperones basigin(CD147)and glucose transporter type 1(GLUT-1), as well as the anoxia biomarker carbonic anhydrase 9(CAIX), all play important roles in head and neck squamous cell carcinomas(HNSCCs), including nasopharyngeal, laryngeal, and oral squamous cell carcinomas. Combining MCT modulation with existing therapies has the potential to improve HNSCC treatment efficacy. This review discusses the mechanisms by which MCTs contribute to development of HNSCC and the current state of research regarding MCT therapeutic targeting.

Key words: Monocarboxylate transporter, Metabolism, Lactic acid, Inhibitor

CLC Number: 

  • R762
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