Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 70-74.doi: 10.6040/j.issn.1673-3770.0.2021.043

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Study on the value of tumor abnormal protein in clinical diagnosis of laryngeal carcinoma

LI Yanjie1, JIA Jian2, YANG Ping2, WAN Baoluo1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China;
    2. Department of Otolaryngology, People's Hospital of Xixian, Xixian 464300, Henan, China
  • Published:2021-09-29

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Abstract: Objective Detection of tumor abnormal protein in patients with laryngeal cancer and healthy people was conducted to analyze the clinical value of tumor abnormal protein in the diagnosis of laryngeal cancer. Methods A total of 95 patients with laryngeal cancer diagnosed in pathology department, People's Hospital from September 2017 to September 2019 were selected as the experimental group, while 95 healthy patients were selected as the control group. All subjects were tested for tumor abnormal protein to explore its application value in the clinical diagnosis of patients with laryngeal cancer. Results The positive rate of tumor abnormal protein in patients with laryngeal cancer was 83.16%, which was higher than that in healthy people(15.79%), and the difference was statistically significant(P<0.001).The positive expression rate of TAP in peripheral blood of patients with lymph node metastasis and stage Ⅲ+Ⅳ laryngeal cancer was higher, and the difference was statistically significant(P<0.05).There was no significant difference in the expression level of abnormal tumor protein in peripheral blood of laryngeal cancer patients with different genders and ages(P>0.05). Conclusion The expression of tumor abnormal protein in peripheral blood of patients with laryngeal cancer has high sensitivity, and tumor abnormal protein has high application value in the clinical diagnosis of laryngeal cancer.

Key words: Tumor abnormal protein, Laryngeal cancer, The value of research

CLC Number: 

  • R739.65
[1] 陈慧君, 宋圣花, 董伟达, 等. 术前外周血纤维蛋白原水平对喉癌预后的影响[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 110-114. doi:10.6040/j.issn.1673-3770.0.2019.530. CHEN Huijun, SONG Shenghua, DONG Weida, et al. Prognostic role of preoperative fibrinogen levels in patients with laryngeal squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 110-114. doi:10.6040/j.issn.1673-3770.0.2019.530.
[2] Arens C, Schwemmle C, Voigt-Zimmermann S. Chirurgische rekonstruktionen beim larynxkarzinom[J]. HNO, 2020, 68(9): 666-677. doi:10.1007/s00106-020-00916-y.
[3] 饶丽华, 张茏, 田令, 等. 喉癌患者CEA、Cyfra21-1、SCC检测与临床病理指标关系[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(15): 1182-1186. doi:10.13201/j.issn.1001-1781.2017.15.010. RAO Lihua, ZHANG Long, TIAN Ling, et al. The clinical signifinace of CEA, Cyfra21-1 and SCC in laryngeal carcinoma's clinicopathological parameters[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2017, 31(15): 1182-1186. doi:10.13201/j.issn.1001-1781.2017.15.010.
[4] Franz L, Alessandrini L, Ottaviano G, et al. Postoperative radiotherapy for laryngeal cancer. The prognostic role of programmed death-ligand 1: an immune microenvironment-based cluster analysis[J]. Pathol Res Pract, 2020, 216(9): 153120. doi:10.1016/j.prp.2020.153120.
[5] Lan F, Zhu M, Qi QF, et al. Prognostic value of serum tumor abnormal protein in gastric cancer patients[J]. Mol Clin Oncol, 2016, 5(1): 216-220. doi:10.3892/mco.2016.877.
[6] 吴永梅, 张霁雯, 蔡琰. 肿瘤异常蛋白(TAP)检测在Barrett食管及食管腺癌临床诊断中的意义[J]. 现代消化及介入诊疗, 2015, 20(2): 83-84,178. doi:10.3969/j.issn.1672-2159.2015.02.001. WU Yongmei, ZHANG Jiwen, CAI Yan. Clinical significance of tumor abnormal protein(TAP)detection in Barrett esophagus and esophageal adenocarcinoma[J]. Modern Digestion & Intervention, 2015, 20(2): 83-84,178. doi:10.3969/j.issn.1672-2159.2015.02.001.
[7] Cheng YJ, Chen YB, Zang GH, et al. Increased expression of TAP is predictive of poor prognosis in patients with non-small cell lung cancer[J]. Cancer Manag Res, 2020, 12: 1941-1946. doi:10.2147/CMAR.S239593.
[8] Wu XY, Huang XN. Clinical application of serum tumor abnormal protein(TAP)in colorectal cancer patients[J]. Asian Pac J Cancer Prev, 2015, 16(8): 3425-3428. doi:10.7314/apjcp.2015.16.8.3425.
[9] 赵丽娜, 张雷. 肿瘤异常蛋白对头颈肿瘤的临床诊断价值[J]. 浙江中西医结合杂志, 2015,25(9): 846-847. doi:10.3969/j.issn.1005-4561.2015.09.016.
[10] 范义燕, 张肖林, 刘秀珍, 等. CPS1在喉鳞癌组织中的表达及临床意义[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 72-76. doi:10.6040/j.issn.1673-3770.0.2019.618. FAN Yiyan, ZHANG Xiaolin, LIU Xiuzhen, et al. Expression and clinical significance of CPS1 in laryngeal squamous cell carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 72-76. doi:10.6040/j.issn.1673-3770.0.2019.618.
[11] Ma A, Fan D, Yan F. A study of the application of TAP combined with transvaginal ultrasound in the diagnosis of early-stage endometrial cancer[J]. Oncol Lett, 2018, 16(4): 5186-5190. doi:10.3892/ol.2018.9250.
[12] Li LX, Zhang B, Gong RZ. Insights into the role of tumor abnormal protein in early diagnosis of cancer: a prospective cohort study[J]. Medicine(Baltimore), 2020, 99(11): e19382. doi:10.1097/MD.0000000000019382.
[13] 韩淼, 周长明, 思超, 等. 喉癌患者血清中SCCAg、CEA、CA19-9、CA72-4和CYFRA21-1的检测及意义[J]. 实用癌症杂志, 2017, 32(9): 1434-1437. doi:10.3969/j.issn.1001-5930.2017.09.011. HAN Miao, ZHOU Changming, SI Chao, et al. Detection value and significance of SCCAg, CEA, CA19-9, CA72-4 and CYFRA21-1 in patients with laryngeal carcinoma[J]. The Practical Journal of Cancer, 2017, 32(9): 1434-1437. doi:10.3969/j.issn.1001-5930.2017.09.011.
[14] Chen WX, Yang LG, Cheng L, et al. Tumor abnormal protein in the diagnosis of breast cancer in patients with a palpable mass[J]. Ann Clin Lab Sci, 2019, 49(3): 297-301.
[15] Sun CQ, Deng F, Meng LJ, et al. Correlation between TAP detection and common digestive tract precancerous lesions[J]. Oncol Lett, 2018, 15(2): 1616-1620. doi:10.3892/ol.2017.7496.
[16] 岳丹, 王晓辉, 付超, 等. 外周血异常糖链糖蛋白(TAP)检测对于肿瘤筛查及早期辅助诊断的意义[J]. 现代检验医学杂志, 2020, 35(5): 62-64,92. doi:10.3969/j.issn.1671-7414.2020.05.016. YUE Dan, WANG Xiaohui, FU Chao, et al. Significance of tumor abnormal protein(TAP)peripheral blood in the detection of tumor screening and early auxiliary diagnosis[J]. Journal of Modern Laboratory Medicine, 2020, 35(5): 62-64,92. doi:10.3969/j.issn.1671-7414.2020.05.016.
[17] 李红, 尹芳, 罗贯虹, 等. 异常糖链糖蛋白与甲胎蛋白在肝癌诊断及预后评估中的应用价值[J]. 胃肠病学和肝病学杂志, 2019, 28(11): 1221-1224. doi:10.3969/j.issn.1006-5709.2019.11.005. LI Hong, YIN Fang, LUO Guanhong, et al. The value of tumor abnormal protein and alpha fetoprotein in the diagnosis and prognosis of liver cancer[J]. Chinese Journal of Gastroenterology and Hepatology, 2019, 28(11): 1221-1224. doi:10.3969/j.issn.1006-5709.2019.11.005.
[18] 谭婧宇, 卢梅梅, 梁静秋, 等. 外周血肿瘤异常蛋白在结直肠癌患者中的表达及预后价值研究[J]. 重庆医科大学学报, 2020, 45(9): 1336-1340. doi:10.13406/j.cnki.cyxb.002639. TAN Jingyu, LU Meimei, LIANG Jingqiu, et al. Expression and prognostic significance of tumor abnormal protein on peripheral blood in colorectal cancer patients[J]. Journal of Chongqing Medical University, 2020, 45(9): 1336-1340. doi:10.13406/j.cnki.cyxb.002639.
[19] 沈国栋, 陆羽玲, 张黎. 肿瘤异常蛋白与乳腺癌分子标志物关系及其在乳腺癌新辅助化疗中的应用[J]. 中国实用医药, 2018, 13(33): 36-38. doi:10.14163/j.cnki.11-5547/r.2018.33.017.
[20] 彭峰, 彭奕华, 张宏华, 等. 非小细胞肺癌化疗前后血清糖类抗原125、肿瘤异常蛋白水平变化及其与疗效的关系[J]. 陕西医学杂志, 2020, 49(7): 851-854. doi:10.3969/j.issn.1000-7377.2020.07.023. PENG Feng, PENG Yihua, ZHANG Honghua, et al. Changes of serum CA125 and TAP levels before and after chemotherapy for non-small cell lung cancer and their relationship with curative effect[J]. Shaanxi Medical Journal, 2020, 49(7): 851-854. doi:10.3969/j.issn.1000-7377.2020.07.023.
[21] 许刚, 徐惠, 冯志俊, 等. 肿瘤异常蛋白在宫颈癌患者同步放化疗中的变化及临床意义[J]. 中国现代医学杂志, 2018, 28(3): 87-91. doi:10.3969/j.issn.1005-8982.2018.03.018. GANG Xu, HUI Xu, ZHIJUN Feng, et al. Variation of tumor abnormal protein in concurrent radiotherapy and chemotherapy of patients with cervical cancer and its clinical significance[J]. China Journal of Modern Medicine, 2018, 28(3): 87-91. doi:10.3969/j.issn.1005-8982.2018.03.018.
[22] 杨双祥, 周永安, 黄娅芬, 等. 腹腔镜宫颈癌根治术后TAP、CEA水平变化及其临床意义[J]. 局解手术学杂志, 2018, 27(6): 447-450. doi:10.11659/jjssx.03E018024. YANG Shuangxiang, ZHOU Yongan, HUANG Yafen, et al. Changes in TAP and CEA after laparoscopic radical resection of cervical cancer and their clinical significance[J]. Journal of Regional Anatomy and Operative Surgery, 2018, 27(6): 447-450. doi:10.11659/jjssx.03E018024.
[23] 尤玮, 王泽新, 李佳, 等. 肿瘤异常蛋白检测在食管癌诊断中的价值研究[J]. 标记免疫分析与临床, 2017, 24(3): 279-281,337. doi:10.11748/bjmy.issn.1006-1703.2017.03.010. YOU Wei, WANG Zexin, LI Jia, et al. The significance of tumor abnormal protein in the diagnosis of esophageal cancer[J]. Labeled Immunoassays and Clinical Medicine, 2017, 24(3): 279-281,337. doi:10.11748/bjmy.issn.1006-1703.2017.03.010.
[24] Mallard BW, Tiralongo J. Cancer stem cell marker glycosylation: Nature, function and significance[J]. Glycoconj J, 2017, 34(4): 441-452. doi:10.1007/s10719-017-9780-9.
[25] 高英恺, 仲云, 杨凡, 等. p63与CD34在喉鳞状细胞癌早期诊断中的意义[J]. 中外医疗, 2018, 37(18): 31-33. doi:10.16662/j.cnki.1674-0742.2018.18.031. GAO Yingkai, ZHONG Yun, YANG Fan, et al. Thesignificance of p63 and CD34 in the early diagnosis of laryngeal squamous cell carcinoma[J]. China & Foreign Medical Treatment, 2018, 37(18): 31-33. doi:10.16662/j.cnki.1674-0742.2018.18.031.
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