Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (5): 46-50.doi: 10.6040/j.issn.1673-3770.0.2021.263

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Clinical efficacy of lecithin complex iodine capsule in the adjuvant treatment of retinal vein occlusion

GU Ranran1, LI Fengjiao2, JIAO Wanzhen2, CUI Yanyan1, ZHAO Bojun2   

  1. 1. First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China;
    2. Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2022-09-20

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Abstract: Objective To explore the clinical efficacy of lecithin complex iodine capsule combined with ranibizumab in the treatment of macular edema secondary to retinal vein occlusion(RVO-ME). Methods 40 patients(40 eyes)with RVO-ME who were admitted to our hospital from January 2020 to February 2021 were randomly divided into two groups: ranibizumab group and lecithin combination group, 19 cases(19 eyes)in ranibizumab group and 21 cases(21 eyes)in lecithin combination group. The patients in ranibizumab group were treated with intravitreal injection of ranibizumab every 4 weeks, and the patients in lecithin combined group were treated with lecithin complex iodine capsule combined with ranibizumab every 4 weeks, follow-up every 4 weeks during the 12 weeks observation period, The changes of intraocular pressure(IOP), best-corrected visual acuity(BCVA), fundus bleeding area, central macular thickness(CMT), fovea avascular zone(FAZ), choriocaphillaris flow area(CFA), superficial capillary plexus(SCP)and deep capillary plexus(DCP)were observed before and after treatment. Results BCVA(LogMAR)and CMT of the two groups at each treatment time point were significantly improved compared with those before treatment, and there was no significant difference between the two groups. FAZ and SCP: there was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups. Fundus hemorrhage area: the fundus hemorrhage area of the two groups at each treatment time point was significantly lower than that before treatment. The fundus hemorrhage absorption of the lecithin combined group at each treatment time point was better than that of the ranibizumab group, and the difference was statistically significant. CFA in the eyes of the two groups increased before and after teatment, the difference was statistically significant, and there was no significant difference between the two groups. After 12 weeks of follow-up, DCP in the eyes of the two groups showed a significant increase trend, the difference was statistically significant, and the improvement of DCP in lecithin combined group was better than that in leizumab group, the difference was statistically significant. Conclusions Lecithin complex iodine capsule in the adjuvant treatment of retinal vein occlusion can achieve a better result in promoting the absorption of fundus hemorrhage and increase the density of deep retinal capillaries.

Key words: Retinal Vein Occlusion, Ranibizumab, Lecithin Complex Iodine, Macular Edema

CLC Number: 

  • R774.1
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