氨基糖苷类抗生素耳毒性影响因素研究进展

doi:10.6040/j.issn.1673-3770.0.2021.097

Abstract

Abstract: Aminoglycoside antibiotics are potent and widely used primarily in the treatment of serious bacterial infections.A serious complication from using these antibiotics is ototoxicity.The main cause of ototoxicity is drug-triggered sensory hair cell damage in the inner ear.Molecular events that engender aminoglycoside-induced sensory hair cell death have been extensively studied.Recent reports have revealed the external factors that increase drug toxicity and the genetic factors that lead to increased sensitivity in individuals, which may provide prospective approach for individualized treatment and prevention of ototoxicity. In this review,we discuss the ototoxicity mechanism of aminoglycoside antibiotics, factors affecting drug ototoxicity,and potential intervention strategies to prevent ototoxicity.

Key words: Aminoglycoside antibiotics, Ototoxicity, Genetic susceptibility, Inflammation, Glucocorticoid

CLC Number:

R764

LI Cong, LI Ling, LIU Tingyan, CHEN Liang. Research progress on influencing factors of aminoglycoside antibiotic ototoxicity[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 128-134.

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