Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 123-128.doi: 10.6040/j.issn.1673-3770.0.2020.031

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Correlation between high-mobility group box-1 and allergic rhinitis

ZHU ZhengruOveriew,ZHANG XiaobingGuidance   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Published:2021-01-11

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Abstract: Allergic rhinitis(AR)is a noninfectious inflammatory disease of the nasal mucosa mediated by IgE and characterized by the upregulation of inflammatory mediators and infiltration of inflammatory cells in the nasal mucosa. As a typical warning protein and damage-related model molecule, high-mobility group box-1(HMGB1)plays a variety of roles in mediating inflammatory response, cell migration, and tissue invasion. Currently, studies on HMGB1 and allergic diseases mainly focus on systemic lupus erythematosus, asthma, and atopic dermatitis, whereas the role of HMGB1 in AR is still controversial. This article summarizes the relevant researches on the role of HMGB1 in the pathogenesis of AR.

Key words: High mobility group box-1, Allergic rhinitis, Pathogenesis, Inflammation, Receptor, Signal pathway

CLC Number: 

  • R765.21
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