Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (6): 80-84.doi: 10.6040/j.issn.1673-3770.0.2022.290

• Clinical Study • Previous Articles     Next Articles

The correlation between γ-glutamyl transferase and obstructive sleep apnea syndrome-related hypertension

WANG Teng, YU Lin, LI Sui   

  1. Department of Otolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China
  • Published:2023-12-15

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Abstract: Objective This study aimed to investigate the correlation between serum levels of γ-glutamyl transferase(GGT)and the severity of obstructive sleep apnea syndrome(OSAHS)and hypertension. Methods A total of 312 patients with OSAS who underwent polysomnography were selected as the research subjects. They were divided into four separate groups according to the apnea-hypopnea index(AHI)scores: control group(AHI 0-4), mild OSAS group(AHI 5-15), moderate OSAS group(AHI 16-30), and severe OSAS group(AHI>30). The venous blood GGT was measured within 24 hours after admission, and the differences between groups were compared. The related influencing factors were analyzed by multiple stepwise regression method. The OSAS subjects were further classified into two groups: those with hypertension and those without hypertension. The GGT levels in the groups were compared and statistically analyzed, binary logistic regression was used to analyze the predictive effect of serum GGT level in OSAHS patients with hypertension. Results The serum GGT levels were positively correlated with OSAS severity, and the difference was statistically significant(P<0.001). Multiple stepwise regression analysis showed that serum γ-glutamyl transferase(GGT)was independently correlated with oxygen desaturation index(β=0.557, P<0.001). The level of serum GGT in OSAHS patients with hypertension was significantly higher than that in OSAHS patients without hypertension(P<0.001). The logistic regression analysis showed that elevated serum GGT was an independent predictor of OSAHS with hypertension(OR=1.015, P<0.001). Conclusion The serum GGT levels are positively correlated with the severity of OSAHS and can be used as an independent risk factor to predict the likelihood of developing OSAHS with hypertension.

Key words: Obstructive sleep apnea syndrome, γ-glutamyl transferase, Hypertension, Predictive value

CLC Number: 

  • R76
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