细胞焦亡在耳鼻咽喉科疾病中的研究进展

doi:10.6040/j.issn.1673-3770.0.2024.181

Abstract

Abstract: As one of the programmed cell death modes, the process of cell pyroptosis cannot be separated from caspase family and gasdermin family, and accompanied by the occurrence of inflammatory response, the main process is that the caspase family is activated, and then acts on the N-terminal structure of gasdermin family, which causes the cell membrane to be ruptured through translocation insertion on the surface of the cell membrane, oligomerisation, etc. The cell membrane is then activated by the caspase family, and the caspases are activated. The cell membrane is then activated by the caspase family and the caspases are activated. After the formation of lacunae, the volume gradually expands and eventually the cell membrane ruptures and the substances inside the cell are released from the cell, triggering a strong inflammatory response in the organism. In recent years, cell death has become one of the hot spots in ENT research. In this article, we review the discovery process, molecular mechanism of cellular pyroptosis and its research progress in common otolaryngological diseases such as chronic sinusitis, allergic rhinitis, nasopharyngeal carcinoma, hearing loss, head and neck tumours, and so on.

Key words: Pyroptosis, Inflammatory bodies, Chronic sinusitis, Allergic rhinitis, Nasopharyngeal carcinoma, Hearing loss, Head and neck tumor

CLC Number:

ZHANG Jingyi, DONG Xiangyi, MU Yakui, SONG Xicheng. Research progress on pyroptosis in otorhinolaryngology diseases[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 140-148.

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[6]	ZHANG Lijing, FENG Xiaoxing, LIU Nanxian, ZHAO Huiming, CHEN Yuehua. Graphene cured nasal mask combined with subcutaneous specific immunotherapy of dust mite in patients with dust mite allergic rhinitis application analysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 26-32.
[7]	ZHANG Jiajia, SHI Anni, XING Yu, HONG Yuying, BAI Peng. Acupuncture combined with western medicine for the treatment of total deafness in sudden sensorineural hearing loss: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 88-92.
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[9]	YANG Min, ZHU Xiaoyan, WANG Xu. Progress in metabolomics research in sensorineural hearing loss [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 113-121.
[10]	ZHANG Zhen, YANG Zhuoying, ZHOU Jiani, ZHANG Dawei, CHEN Renjie. Efficacy and safety of ciclesonide nasal spray in the treatment of seasonal allergic rhinitis:a Meta-analysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 13-20.
[11]	CHONG Weikun, WANG Juan. Efficacy of Omalizumab in children with moderate and severe allergic asthma and chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 21-26.
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