铁死亡在呼吸道炎症性疾病中的作用及研究进展

doi:10.6040/j.issn.1673-3770.0.2022.241

Abstract

Abstract: Ferroptosis is a form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides. In recent years, more studies have explored the mechanism of ferroptosis, identifying the crucial role of numerous molecules in its regulation. Emerging evidence has identified ferroptosis in various respiratory inflammatory diseases such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infections, and even COVID-19, suggesting its crucial role in respiratory inflammatory disorders. Thus, drugs targeting the mechanism of ferroptosis may have significant therapeutic efficacy in respiratory inflammatory diseases. This review focused on the role and molecular mechanism of ferroptosis in respiratory inflammatory diseases, and proposed multi-angle regulation of ferroptosis as a promising potential strategy for their clinical treatment.

Key words: Ferroptosis, Asthma, Chronic obstructive pulmonary disease, Pneumonia, Nasal polyp, Allergic rhinitis

CLC Number:

SUN Xiwen, LUO Chunyu, LI Zhipeng, ZHANG Weitian. Role of ferroptosis in inflammatory diseases of the respiratory tract: a review of recent advances[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 24-32.

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Role of ferroptosis in inflammatory diseases of the respiratory tract: a review of recent advances

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