JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Effect of microwave radiation on cell proliferation activity and the cell cycle of nasopharyngeal carcinoma

MA Jing1, LIU Bin2   

  1. 1. Department of Otorhinolaryngology； 2. Department of Pathology, Lanzhou General Hospital, Lanzhou Command, Chinese PLA, Lanzhou 730050, China

  • Received:1900-01-01 Revised:1900-01-01 Online:2008-08-16 Published:2008-08-16
  • Contact: MA Jing

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Abstract:

Objective〓〖WTBZ〗To explore the effect of microwave radiation on cell proliferation activity and the cell cycle of nasopharyngeal carcinoma. 〖WTHZ〗Methods〓〖WTBZ〗There were four groups: the control, 10, 20 and 30mW/cm2 microwave radiation groups. MTT and flow cytometry (FCM) methods were used to detect the cell proliferation activity and the cell cycle of nasopharyngeal carcinoma. 〖WTHZ〗Result〓〖WTBZ〗With an increase of microwave radiation dosage, the MTT assay showed that the rate of cell activity was reduced from 100% to 76.75% and 65.07% at 20 and 30 mW/cm2 microwave radiation and sub-diploidy peaks were found. 〖WTHZ〗Conclusion〓〖WTBZ〗Microwave radiation inhibits cell proliferation and promotes cell apoptosis of nasopharyngeal carcinoma.

Key words: Nasopharyngeal carcinoma, Cell cycle,

Microwave, Apoptosis

CLC Number: 

  • R739.65
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