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Table of Content

    16 April 2012 Volume 26 Issue 2
      
    Articles
    Clinical individual case analysis of poor cases after cataract surgery
    LI Jian-ping,ZHU Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  1-1. 
    Abstract ( 1087 )   PDF (1036KB) ( 1933 )   Save
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    One case of viral cornea endotheliitis
    GUO Hui, WU Xin-yi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  2-2. 
    Abstract ( 976 )   PDF (960KB) ( 1840 )   Save
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    Complicated cataract surgery in 1 case
    CHEN Yuan-zhi1, DANG Guang-fu2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  3-3. 
    Abstract ( 1014 )   PDF (960KB) ( 1196 )   Save
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    One case of intraocular lymphoma
    HENG Yan-juan, WANG Yu, FAN Chuan-feng, SHU Xiang-wen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  4-5. 
    Abstract ( 1091 )   PDF (1155KB) ( 1346 )   Save
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    Ocular trauma complicated iris cyst in 1 child
    WANG Xing-rong, WEN Ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  6-6. 
    Abstract ( 980 )   PDF (1411KB) ( 1188 )   Save
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    Vogt-KoyanagiHarada disease misdiagnosed as central retinitis
    SONG Qi1, WANG Huan-yi2, QIN Xue-jiao1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  7-8. 
    Abstract ( 1272 )   PDF (1501KB) ( 1537 )   Save
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    A survey to assess otolaryngologist′s knowledge and attitudes about obstructive sleep apnea hypopnea syndrome.
    ZHANG Lei, CAI Xiao-lan, LI Xue-zhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  9-14. 
    Abstract ( 1048 )   PDF (1012KB) ( 1642 )   Save
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    Objective   To include and analyze the knowledge and attitudes about obstructive sleep apnea hypopnea syndrome(OSAHS)in the clinicians of departments of Otolaryngology. Methods   A validated questionnaire from the USA, the “Obstructive Sleep Apnea Knowledge and Attitudes Questionnaire(OSAKA)” was used. The questionnaire was mailed to ENT doctors in 41 public hospitals in Shandong Province. Results   334 valid questionnaires(95.70%)were returned. The correction rate in average of all knowledge items were 78%. Among them, 61.38% clinicians mistakenly thought the“Uvulopalatopharyngoplasty is curative for the majority of patients with obstructive sleep apnea”. Only 41.02%(0.41±0.49)doctors could correctly answered the question“OSAHS in female can only present as fatigue”. About 50.90%(0.51±0.50) of responders knew “Less than five apneas or hypopneas per hour is normal in adults”. More scored on the knowledge OSAKA portion of pathophysiology, but were limited in OSAHS treatment. More than 95% of the participants stated that“As a clinical disorder OSAHS is important or extremely important and it is important to identify patients at risk for obstructive sleep apnea”. However, among them, only 70% felt confident in diagnosis and less than 60% felt confident in managing OSAHS patients. Individual knowledge items did not significantly differ by gender or by whether or not respondents had completed subspecialty training. There was a statistically significant correlation between the total knowledge scores with age and the years in practice. More knowledge was associated with more positive attitudes overall and older in age or longer years in practice. Conclusions   The importance of OSAHS to clinicians of Otlaryngologic departments is well known. It is a key step to recommend that the knowledge and positive attitudes through more continuous education focusing on the diagnosis and treatment and identifying at risk for OSAHS are elevated.

    Cardiologists′  knowledge and attitudes about obstructive sleep apnea hypopnea syndrome:a survey study.
    WEI Xiao, CAI Xiaolan, LI Xue-zhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  15-17. 
    Abstract ( 766 )   PDF (974KB) ( 1724 )   Save
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    Objective   To find out the perception on obstructive sleep apnea hypopnea syndrome (OSAHS) among cardiologists. Methods   Relative information was gathered via a questionnaire delivered to clinicians of departments of Cardiology among  38 public hospitals in Shandong Province and the data were analyzed by the methods of reliability analysis and correlation analysis. Results   Clinicians of cardiology quite grasped the pathogenesis of OSAHS, but did not understand how to treat OSAHS. Conclusions   The importance of OSAHS in clinicians of cardiologic departments is well known. It is a key step to recommend that the knowledge and positive attitudes through more continuous education focusing on the diagnosis and treatment and identifying those at risk for OSAHS are elevated.

    One-stage multiplanar operation in treatment of moderate and severe obstructive sleep apnea syndrome (OSAHS)
    WANG Jie, LIU Qing-jun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  18-22. 
    Abstract ( 1003 )   PDF (999KB) ( 1563 )   Save
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    Objective   To analyze therapeutic effects, complications, total maintenance charge and total hospitalization days of 169 OSAHS cases, and to discuss the value of multiplanar operation of the upper airway in the treatment of moderate and severe OSAHS sufferers. Methods   The clinical data of 169 OSAHS patients who showed multiplannar blocking signs from August 2001 to January 2010, including operation scheme, PSG altogether with  Epworth sleepiness score before and after operation, total hospitalization expences and total hospitalization days, were reviewed. The advantages and disadvantages of different operation plans, rescuing experience and the tactics dealing with complications were discussed. Reasults   In the 169 OSAHS sufferers, 81 received one-stage multiplanar operation, including 70 nasal /palatopharyngeal plane operation, 9 palatopharyngeal/tongue base plane operations, and 2 H-UPPP/tongue base radiofrequency reduction/nasal ablations.29 chose consecutive surgical therapy in which nasal plane or palatopharyngeal plane operation was first done, and the operation on another plane done later. 59 acepted H-UPPP only. No death or serious complications occurred in the perioperation period and follow up(0.5 to 2 years). Epworth sleepiness score and PSG before and after operation were used to evaluate the therapeutic effects. Compared to the single H-UPP, one-stage multiplanar operation and consecutive multiplanar operation both showed advantages in decreasing AHI and ODI, but  no significant difference in decreasing  ESS or  raising SaO2min among the three types of operations was identified. The overall effective rates of the multiplanar operation group and the single H-UPPP group were 88.9%(72/81), 66.1%(39/59), respectively.  For single H-UPPP, the mean hospitalization charge was 7500±439 yuan, and the mean hospitalization stay was 9.8±1.3 days, while for the one-stage multi-planar operation group and consecutive multiplanaroperation group, the corresponding data were  10541±1043 yuan, 11.4±1.5 days, 14500±1097 yuan and  18.6±2.1 days. Complications, such as dysphagia, were more likely to happen in the one-stage multiplanar operation group(28/81)than the single H-UPPP group(7/59). Conclusions   Both one-stage multiplanar operation and consecutive multiplanar operation are better than single H-UPPP in the treatment of moderate and severe OSAHS sufferers who show multiplan blocking signs. And there is no significient difference bttween the therapeutic effects of one-stage multiplanar operation and consecutive multiplanar operation. Although the complications are more commonly seen the in onestage multiplanar operation group, no death or serious complications occurred. Also, one-stage operation can effectively decrease the cost of hospitalization, shorten hospital stay, and improve the curative rate.

    Expression and clinical significance of programmed cell death 5 (PDCD5) in laryngeal squamous cell carcinoma.
    ZHANG Shu-jia1, LI Pei-hua2, JIA Wen-bo1, XU Heng-guang1, BAO Feng-xiang1, LI Li1. 1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  23-26. 
    Abstract ( 898 )   PDF (1330KB) ( 1142 )   Save
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    Objective   To determine expression of programmed cell death 5 (PDCD5) in laryngeal squamous cell carcinoma and reveal its possible correlation to clinical parameters. Methods   Expression of mRNA and protein of PDCD 5 were analysed in 41 laryngeal squamous cell carcinoma and 29 normal tissues adjacent to the carcinomas with reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. Immunohistochemistry was also applied to investigate protein expressions of PDCD 5 in squamous cell carcinoma and matched normal tissues. Result   The normal tissues adjacent to tumor lesions expressed higher levels of PDCD5 mRNA, whereas most of laryngeal squamous cell carcinoma expression was reduced or did not expres(P=0.006). Compared with the normal tissues, most carcinoma exhibited less PDCD5 protein(P=0.012). By immunohistochemistry, the loss of PDCD5 expression was identified as a frequent event in laryngeal squamous cell carcinoma. Expressions of PDCD5 protein and mRNA were correlated with clinical stages and histological gradings.There was no correlation with age,gender, tumor site or lymph node metastasis. Conclusions   The decrease or absence of PDCD5 expression is a frequent event in laryngeal squamous cell carcinoma, which might contribute to tumor development and progression. 

    Expression and  relationship of HMGA1 and Ezrin in laryngeal carcinoma
    PAN Chun-chen1, ZHANG Xiao-peng2, LAI Hai-chun3, WANG De-sheng3
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  27-31. 
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    Objective   To investigate expression of HMGA1 and Ezrin in laryngeal carcinoma and analyze their clinical significance and relationship. Methods   Expression of proteins of HMGA1 and Ezrin was semi-quantitatively analyzed by SP immunohistochemical staining in 50 cases of laryngeal carcinoma. 30 cases of laryngeal polyp and 30 cases of atypical laryngeal hyperplasia were studied as controls. Expressions of mRNA of HMGA1 and Ezrin were analyzed by rea-time PCR in 30 cases of laryngeal carcinoma. Also, 30 cases of  cancer cutting-margin were studied as controls. Results   (1) The positive rates of HMGA1 protein were 68.0%(34/50), 53.0%(16/30) and 13.0%(4/30) in laryngeal carcinoma, atypical hyperplasia of laryngea and laryngeal polyps, while Ezrin protein were 64.0% (32/50), 50.0%(15/30) and 23.3%(7/30), respectively. (2) Expression of HMGA1 and Ezrin proteins and mRNA was closely related to clinical stage, pathological stage and lymph node metastasis (P<0.05), but not  patients′age, gender or tumor location(P>0.05). There was a positive correlation between the protein and mRNA expression of HMGA1 and Ezrin. (r=0.385,P=0.000, by real time PCR;χ2 =7.172,r=0.379,P=0.012, by IHC).  Conclusion   Over-expression of HMGA1 and Ezrin may contribute to the carcinogenesis, development and metastasis of laryngeal carcinoma. They may be new markersto evaluate the prognosis of laryngeal carcinoma.

    Clinical practice in peri-operative care of head-neck tumor in ultrasound-guided fine needle aspiration cytology
    QU Chen-hui1, SHOU Jian-wei1, GUO Yan1, WANG Li-jie2, YU Xiao-xu3
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  32-34. 
    Abstract ( 1042 )   PDF (1242KB) ( 1337 )   Save
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    Objective   To study ultrasound-guided fine needle aspiration cytology examination, and to improve the peri-operation head-neck cancer diagnosis rate. Methods   Randomly 30 patients with head-neck cancer had neck lump or fine needle aspiration cytology in lymph nodes performed, especially in detection and analysis of sentinel lymph nodes. Results   Among the patients, the success rate was 93.33% (28/30), and histological diagnosis rate was 93.33% (28/30). Only one case needed a partial pressure bandage because of puncture site hematoma, while others had no special treatment. Conclusion   Ultrasound-guided fine needle aspiration cytology examination indirectly reduced the positive margin rate and cutside residual tumor, and obtained maximum functional surgery.

    Apoptosis and the injury of the inner ear
    TIAN Tian-jie1, GENG Yang1, YE Qing1,2, ZHANG Xian-zeng3, XIE Shu-sen3, SHEN Fan1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  35-38. 
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    Objective   To investigate whether or not apoptosis participates in the final injury of inner ear caused by laser,and explore the mechanism of the injury. Methods   Twentyfour male guinea pigs with normal hearing were divided into the control group, in which only the otocyst was opened to expose the round window niche and experimental groups A, B and C. Each group had six guinea pigs. The last three groups underwent the fenestration on the basal turn of the left cochlea with superpulse CO2 laser at a power of 1W, 3W and 5W respectively. Auditory brainstem response(ABR)was recorded one day before the operation and antemortem. Scanning electron microscopy was used to evaluate cochlear morphology. The TUNEL method was used to detect apoptotic cells in the inner ear. Results   The thresholds of postoperative ABR were higher than those preoprative in experimental groups B and C(P<0.05). The cilla of hair cells mostly disappeared with spaces between the hair cells in experimental group C, were partially scattered in experimental B compared with the control group and group A which were normal. Obvious TUNEL-positive cells could be detected in spiral ganglion cells, cochlear nerve cells, outer hair cells in group C,while few were found in group B compared with the control group and group A which appeared normal. Conclusions   The high peak power superpulse CO2 laser could damage the cochlear morphology and function of the guinea pig, and apoptosis plays a critical roll in it.

    Correlation between levels of estrogen and auditory and vestibular functions in post-menopause with Meniere′s disease
    JIAN Hui-rong, YU Gang, CHEN Gang, LIN Nai-fen, WANG Hai-bo
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  39-41. 
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    Objective   To investigate  the correlation between the levels of estrogen and high stimulus  rate  -auditory  -brainstem   response  test, and auditory and vestibular functions in post-menopause  with Meniere′s disease. Methods   43 patients with Meniere′s disease served as the experimental group and  another 30 post-menopausal healthy women as the control group, both had the levels of estrogen and pure tone audiometry determined, and a high  stimulus  rate   auditory   brainstem  response  test (ABR) and  a bithermal  caloric  test were performed. Results   The mean level of E2 was significantly lower in the experimental group than in the control group(t=2.60, P<0.05). The mean level of high  stimulus  rate   ABR  was significantly higher in the experimental group than in the control group(left ear: P<0.05; right ear: P<0.05). The mean level of unilateral weakness was significantly higher in the experimental group than in the control group(P<0.01). The mean level of average hearing threshold was significantly higher in the experimental group than in the control group(left ear P<0.01; right ear P<0.01). The E2 level in the experimental group was negatively correlated with its high  stimulus  rate  ABR level(left r=-0.229, P<0.05; right r=-0.220, P<0.05), and the E2 level in the experimental group was negatively correlated with  its unilateral weakness level(r=-0.328, P<0.05), but the E2 level in the experimental group had no correlation with its average hearing threshold.  ConclusionT   he present work suggested that the decrease of estrogen level might be lead to microcirculatory ischemia of the inner ear, and the estrogen level was positively correlated with vestibular function. Estrogen affected  occurrence and development of Meniere′s disease in post-menopause to some extent.

    Effect of concomitant vertigo on the prognosis of idiopathic sudden hearing loss
    LIANG Zhi-cheng, QIN Guan-duan, MO Lian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  42-43. 
    Abstract ( 1179 )   PDF (961KB) ( 1467 )   Save
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    Objective   To investigate the effect of concomitant vertigo on the prognosis of idiopathic sudden hearing loss. Methods   107 cases of  idiopathic sudden hearing loss(ISHL)were divided into two groups depending on whether or not there was accompanying vertigo. Analysis of therapeutic effects on the two groups was perfromed. Results   The effective rates for the cases with or without accompanying vertigo were 81% and 51%(P<0.05). Conclusion   Prognosis of idiopathic sudden hearing loss with concomitant vertigo is poorer than in patients without it.

    Therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness
    MA Ya-lin1, REN Ping-zhi2, CHAI Mao-wen1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  44-45. 
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    Objective   To explore the therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness. Methods   150 patients with sudden deafness were randomly divided into the Xuesaitong group, the Gastrodin group and the combined group, with 50 cases in each group. The combined group was synchronously treated with Xuesaitong and Gastrodin. Their hearing therapeutic efficacies were compared. Results   The total effective rate and recovery rate were 72% and 20% in the Xuesaitong group, 68% and 18% in the Gastrodin group,and 88% and 38% in the combined group. They were significantly higher in the combined group than in the other two groups (all P<0.05). Conclusion   The combined therapy for sudden deafness is obviously better than individual therapy.

    Evaluation of MIP in HRCT  in Incudomalleolar Dislocation after injury
    YU Li1, SUN Xiao-wei2, DING Yuan-ping3, DOU Fen-fen2, ZHAO Qiu-liang1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  46-48. 
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    Objective   To evaluate the diagnostic value of maximum intensity projection (MIP)in  high-resolution computed tomography (HRCT)in Incudomalleolar Dislocation after injury. Methods   10  patients  (11 ears) with traumatic head injury were scanned with HRCT, while the original data were processed with multiplanar reformations(MPR )and MIP. From the images generated by these techniques, the ossicular chain structure was observed and compared  with the findings in the operation. Results   Among the 10 patients(11 ears), incudomalleolar dislocations were well visualized in 4 ears on axial CT images, and  3 ears on Multiple Planar Reconstruction coronal CT images. 6 ears of incudomalleolar dislocation were identified by maximum intensity projection (MIP) both in axial and coronal CT images, which were further confirmed by the operation. During the surgery, there were 6 ears with incudomalleolar dislocation, 7 ears with tympanic membrane perforation(combined with incudomalleolar dislocation in 3 ears), and 1 ear with incudostapedial dislocation. Conclusion   Maximum intensity projection with high-resolution CT can improve the diagnosis of incudomalleolar dislocation.

    Clinical observation of self ear cartilage tympanoplasty for adhesive otitis media
    WU Hong-liang1, TANG An-zhou2, LIU Qiang-he1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  49-50. 
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    Objective   To observe the curative effect of self ear cartilage tympanoplasty on adhesive otitis media. Methods   The data of 14 patients with adhesive otitis media who were treated with tympanoplasty mediated by the implantation of self ear cartilage were retrospectively reviewed, and intra-operative nidus records, and post-operative eardrums and hearing improvement level were analyzed. Results   All patients had dry ears after one month, including healing in 13, marginal crack in 1, ossicular chain reconstruction in 3,  and hearing loss in 1. The pre-operative average ABG (250, 500, 1000, and 2000kHz) was 50.25dB, the average ABG (250, 500, 1000, and 2000kHz) after one year was 17.22dB, and the average ABG was reduced by more than 25dB. Conclusion   It is feasible to treat adhesive otitis media by ear cartilage reconstruction. Clearing away nidus in operation and ensuring that Eustachian tube is open are very important for ideal effect.

    A follow-up study of quality of life of 120 cases of chronic nasalsinusitis after endoscopic sinus surgery.
    ZHANG Xia1, XIA Li-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  51-54. 
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    Objective   To investigate the clinical significance of regular follow-up of chronic nasal-sinusitis symptom improvement and quality of life impact after endoscopic sinus surgery. Methods   From December 2009 to September 2010 120 patients with sinusitis according to chronic nose-sinusitis diagnosis and treatment guidelines of the 2008 Nanchang standard were enrolled in our department and were divided into chronic nose not associated with sinusitis and chronic nasal polyps and sinusitis associated with nasal polyp groups (n=60). Two groups of patients were on regular follow-up dressing for one year. The main symptom status and quality of life improvement of all patients were evaluated before and after 1, 3, 6 and 12 months. Results   Of 60 patients without nasal polyps, at 6 months 36 cases were cured, 20 cases improved, and 4 cases were invalid. At 12 months 50 patients were cured, 7 cases improved, and 3 cases invalid. Of the nasal polyps group, at 6 months 30 cases recovered, 27 cases improved, and 3 cases were invalid. At 12 months 37 cases were cured, 20 cases improved, and 3 cases were invalid. The two groups had statistically significant differences between disease outcomes. At 1, 3, 6, and 12 months after endoscopic sinus surgery, the first major symptom scores decreased (P<0.01); Compared with the preoperative, the 20 items and 5 items scores rated from 1 month also declined (P<0.01). Conclusion    Endoscopic sinus surgery with regular follow-up dressing can significantly improve surgical outcome.

    Epidemiological investigation of allergic rhinitis in the Qingdao area
    GAO Rong-li1, DING Jian2, ZANG Yan-wei3, YAN Shu1, LIU Ting-ting1, LIU Zan-gang4, GONG Xiang-gui5, ZHOU Xiao-bin6, LI Na1, ZHANG Nian-kai1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  55-60. 
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    Objective   To investigate the morbidity of allergic rhinitis(AR) in the Qingdao area and its correlative factors. Methods   A questionnaire survey on AR was performed in the Qingdao area. We applied over two-stage sampling and cluster sampling methods to the mental health of permanent residents, excluding hypertension, diabetes mellitus and rheumatic disease, aged from 5-70 years in the Qingdao area including seven district and five cities. Our investigation had three stages: questionnaire survey, screening of suspected AR patients according to the results of the questionnaire, and suspects of AR.Diagnosis criteria of AR were the guide of AR in diagnosis and treatment in 2009. Results   2052 questionnaires were available. The effective rate was 85.5%.The prevalence rate of AR in residents aged from 5-70 was 12.08% in Qingdao City. The difference of prevalence between females 11.3% and males 12.7% was statistically insignificant(χ2=0.918, P>0.05). The difference of prevalence between city 15% and village 8% was statistically significant(χ2=23.86, P<0.05). According to the classification criteria of ARIA in 2001, 95 residents suffered from intermittent AR, while 153 suffered from persistent AR. The most common allergens of AR were dermatophagoides farinae, house dust mite and shrimp. Conclusion   The prevalence rate of AR in residents is 12.08%. The most common allergens of AR are dermatophagoides farinae, house dust mite and shrimp. The prevalence rate of seasonal allergic rhinitis is less than sustainable, in the village less than in the city.

    Variation of nasal cavity airflow on the expiratory phase by a smoke tracer agent
    HUANG Peng1,ZHANG Shu-jun1, LI Zhao-hui1, SONG Shan-fang1, CHEN Xue-song1, LU Xia1, DENG Yuan-xin1, WANG Hong-tian2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  61-63. 
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    Objective   To study the variation of airflow curves in the nasal cavity and airflow in different anatomical regions.  Methods   Ten volunteers with normal nasal mucosa were selected by a nasal endoscope examination. Electronic smog was breathed by volunteers through smoking, and kept in the oral pharynx and lower air passage. The normal airflow variation was observed when respirations were conducted for 1 second, 1.5 seconds and 2 seconds.  Results   Upward and laminar airflow passed through the roof of the nasopharynx, most of which curved to the common meatus, and a small amount rushed at the middle turbinate and flowed in the middle meatus and the olfactory sulcus, but only a tiny minority rushed into the inferior meatus from the back and moved in a turbulent flow. The majority of the airflow was turbulent when passing limen nasi.   Conclusion   Direction is changed when airflow passes a bank between the roof of nasopharynx and posterior naris, most of which runs in the common meatus base, with very little in the superior meatus. The majority airflow in the inferior meatus is turbulent. Expiratory airflow has little effect on the mucous membrane of the middle meatus and olfactory sulcus.

    Hemostasis with transfusion apparatus,electrotome and vacuum extracter in nasal endoscopic surgery
    GAO Shui-chao, LI Shi-sheng, TANG Qing-lai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  64-65. 
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    Objective   To expore the method and effect of hemostasis with transfusion apparatus,electrotome and vacuum extracter in nasal endoscopic surgery.  Methods   The bleeding sites were searched for and treated with transfusion apparatus, electrotome and vacuum extracter under nasal endoscopy.  Results   324 cases of intraoperative hemostasis were successful. 5 cases (1.5%) with occurring rehaemorrhagia were controlled by compression of ribbon-gauze with 1% adrenine when extracting the nasal bysma. Conclusion   There are some obvious advantages, including convenient and flexible operation, complete hemostasis, and clear visual fields when hemostasis is treated with transfusion apparatus,electrotome and vacuum extracter in nasal endoscopic surgery.

    Etiology and treatment of patients with lung infection after tracheotomy
    ZHOU Peng1, LI Pei-hua1, LIU Wen1, XU Xue-gu1, KANG Hai-quan2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  66-68. 
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    Objective   To study the etiological characteristic of patients with lung infection after tracheotomy. Methods   The  results of germiculture, the drug sensitivity from phlegm and the clinical data of 245 patients with lung infection after tracheotomy  from January 2008 to December 2010 were reviewed. Results   The incidence rate of iatrogenic infection of lung was 83.6%. 334 strains of pathogenic bacteria were isolated, of which 224 strains of Gram-negative bacilli accounted for 67.1%.The pathogens consisted of Pseudomonas aeruginosa (23.4%), Staphylococcus aureus(17.1%), Klebsiella pneumoniae(11.7%), Acinetobacter baumannii(10.5%), and Escherichia coli(9.6%). The drugs sensitive to Gram-negative bacilli were imipenem(73.7%) and piperacillin/tazobactam(61.1%), while the drugs sensitive to Grampositive cocci were vancomycin(100%) and nitrofurantion(92.9%). Drug resistance for ESBL(+)Gramnegative bacilli and MRSA obviously increased(P<0.05). Conclusions   The main  pathogen of lung infection after tracheotomy in the hospital is Gram-negative bacilli. Antibiotic resistance of bacteria becomes severe. Phlegm cultivation and drug sensitivity testing should be actively developed in the clinic.

    32 cases of facial and neck skin defect
    AN Zeng-xi, LI Xiao-yong, HOU Xiao-feng, JU Ye
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  69-70. 
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    Objective   To explore a suitable method to repair skin wounds on the face and neck with a skin flap. Methods   32 patients  underwent skin flap repair, including rotation flap, rhomboid flap, nasolabial flap, flip flap or free forearm flap. Results   All 32 patients were successfully repaired. The results were satisfactory. Conclusions   Rotation flap, rhomboid flap and nasolabial flap are suitable methods to treat patients with face and neck wounds. Free skin flap depends on the skill of microsurgery.

    Diagnosis value of E-bronchoscopy in pediatric tracheobronchial foreign bodies
    YANG Xiao-jian, ZHANG Jie, CHEN Min, ZHANG Ya-mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  71-73. 
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    Objective   To investigate the diagnostic value of E-bronchoscopy in pediatric tracheobronchial foreign bodies(TBFB). Methods   Records of 99 children who underwent rigid bronchoscopy were reviewed. Results    of chest auscultation, fluoroscopy and E-bronchoscopy were compared with clinical outcome. ResultsComplete removal of TBFB succeeded in 98 patients. The foreign body was coughed out after E-bronchoscopy in 1 patient. The positive rates of history, chest auscultation, fluoroscopy and Ebronchoscopy were 90.91%, 95.96%, 84.84%, 100.00%, respectively. Conclusion   E-bronchoscopy is an accurate and safe method, which could be an ideal procedure for pediatric TBFB.

    Fiberoptic laryngoscopy to examine the esophagus in 209 cases
    LI Jian-fang1, ZHAO Xin-tao2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  74-75. 
    Abstract ( 1535 )   PDF (998KB) ( 1256 )   Save
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    Objective   To study the feasibility and clinical effectiveness of fiberoptic laryngoscopy in examining the esophagus.   Methods   209 patients with esophageal diseases were examined by fiberoptic laryngoscopy.  Results   In 209 cases, 117 cases were diagnosed as 76 reflux esophagitis, 7  esophageal hiatus hernia, 5 mycotic esophagitis, 3 esophageal diverticulum, 3 esophageal varicosis, 1  Barrett esophagus,1  xanthoma of the esophagus, 2 esophageal polyps, 7 carcinoma of the esophagus, 1 carcinoma of gastric cardia and 11 foreign bodies. The results were confirmed by pathological and/or electronic gastroscopy.   Conclusions   Fiberoptic laryngoscopy can be used to examine the esophagus, with little pain for patients. It is helpful for ENT doctors to make differentiation in the throat diseases related to esophageal reflux.

    Changes of extraocular muscle after single direct injection of nerve growth factor in rabbits
    WANG Fei, CHEN Jin-mao, LAI Li-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  76-79. 
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    Objective   To evaluate the morphometry changes of adult rabbit extraocular muscle after direct injection of nerve growth factor(NGF). Methods   In a self-control study, the left eyes of 10 adult rabbits were selected as the experimental group, and the right eyes as the control group.  5μg(0.05mL) NGF was injected into the superior rectus muscle of each experimental eye, and the identical volume of sterilized saline into each control eyes. One week after injection, muscle wet weight and muscle fiber cross-sectional areas were examined. The morphology of the muscles both in the experimental group and the control group was studied by hematoxylin-eosin staining and Van Gieson staining under a light microscope,and the proliferating cell nuclear antigen (PCNA) positive cells in the superior rectus muscle were determined by immunohistochemistry. Results   There was no significant difference in wet weight between the experimental group[(0.14±0.02)g] and the control group[(0.12±0.02)g]. The myofibers mean cross-sectional area of the superior rectus muscle was (9.67±1.82) mm2 in the experimental group,  and (6.97±1.90) mm2 in the control group, with a significant difference between them(t=2.79,P=0.02). No obvious infiltration of inflammatory cells was seen in the muscles after injection. The perimeter of the superior rectus muscle was (167.20±35.55) μm in the experimental group and (127.44±33.64) μm in the control group, with a significant difference between them(t=3.06, P<0.001).The frequencies of large and middle fibers in the muscles were higher in the experimental group than in the control group (χ2=64.16,P<0.001).The proportion of PCNA positive cells was higher in the experimental group than in the control group(χ2=54.61,P<0.001 ). Conclusion   Single direct injection of NGF into extraocular muscles is an effective and safe procedure. NGF can increase myofibers cross-sectional area of the extraocular muscle and promote the proliferation of extraocular muscle fibers.

    Measurements of corneal thickness in the clinic
    YANG Xue-qiu1, ZHAO Jing-jing1, ZHUANG Wen-juan2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  80-82. 
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    The corneal thickness parameter is one of the major examination data of the anterior segment. It is used in the diagnosis of ophthalmological diseases, and it is very important in pre-operative assessment for excimer laser refractive surgery. With the development from contact to non-contact measurements, the corneal thickness measurement becomes more and more accurate and secure. In this review, we summarized the recent advances of different corneal thickness measurements in the clinic.

    Advances in T-bet and TGF-β in allergic rhinitis
    CHEN Fang, LI Xiao-yan.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  83-86. 
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    The differentiation balance of Th1/Th2 is affected by T-box expression in T cells (T-bet), which is responsible for Th1 cell development, inhibits the T lymphocyte immune and plays an important role in the regulation of the immune response. Transforming growth factor-β(TGF-β) as a multifunctional cytokine, mainly  realize Th1 differentiation blockade through the inhibition of T-bet. The review aims to summarize current knowledge about T-bet and TGF-β involvement in the biological characteristics, the role in Th1/Th2 cell differentiation and in allergic rhinitis pathogenesis.

    Reconstruction of the cranial base following endoscopic endonasal skull base surgery:vascularized flaps
    GUO Jin-bao1, ZHANG Wei-tian2, ZHANG Yan1, QIAN Jun-yong1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  87-90. 
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    An appropriate reconstruction for the cranial base strives to recreate a separation of the cranial cavity from the sinonasal cavity, which has introduced new challenges following endonasal skull base surgery. Outcomes after an endoscopic endonasal approach (EEA) for skull base resection depending on vascularized tissue reconstruction are ideal. Local tissue flaps and regional tissue flaps are the first option for reconstruction of the cranial base, because of the characteristic of a more extension, convenience, reliability and robustness. Therefore, the vascularized flaps for skull base reconstruction were reviewed.

    TV box and computer display replace monitors in otolaryngology surgery
    ZHANG Wan-hong, CUI Yi-yun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  92-92. 
    Abstract ( 933 )   PDF (982KB) ( 1500 )   Save
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    A case of sphenoid sinus cyst seeking treatment as visual loss in the first visit
    GUAN Juan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(2):  93-94. 
    Abstract ( 1035 )   PDF (951KB) ( 1395 )   Save
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