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Table of Content

    16 August 2012 Volume 26 Issue 4
      
    Articles
    Diagnosis of chronic otitis media complicated with labyrinthine ossification by imaging studies
    LIU Zhen, LIN Feng, ZHENG Li-gang, XIE Xue-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  3-5. 
    Abstract ( 1009 )   PDF (1664KB) ( 1570 )   Save
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    Objective    To explore the clinical features and diagnostic methods of labyrinthine ossification. Methods   The retrospective analysis was conducted in 3 cases  (3 ears) diagnosed as chronic otitis media complicated with labyrinthine ossification in our department from June 2009 to June 2011. Clinical characteristics, computed tomographic (CT) and magnetic resonance imaging (MRI) manifestations were discussed. Results   Cochlea, semicircular canals and vestibule with ossification occurred in the right ears of the 3 patients. CT showed the cochlear duct and semi-regulatory tube were filled with high-density shadows, and MRI water imaging failed to show the structure of the labyrinth. Conclusion   CT/MRI is an appropriate method for  identification of labyrinthine ossification.

    Tinni TestTM and high stimulus rate auditory brainstem response in  patients with normal hearing
    CAO Xiao-ping, WANG Tian-sheng, GU Dong-sheng, HUANG Ai-ping.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  6-9. 
    Abstract ( 1389 )   PDF (921KB) ( 1532 )   Save
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    Objective   To investigate the clinical characteristics of tinnitus and the relationship between inner ear micro-circulation and tinnitus by examining tinnitus pitch-matching, loudnessin-matching, Feldmann masking curves and high stimulus rat ABR in  tinnitus patients with normal hearing.  Methods   162 patients  with normal hearing and 140 tinnitus patients were enrolled. Tinnitus measurements consisted of pitch-matching, loudnessin-matching, Feldmann masking curves, and high stimulus rat auditory brainstem response (ABR). Results   The tinnitus pitch-matched frequencies of tinnitus patients with normal hearing ranged from 125Hz to 8000Hz,in which 57.3% of them located between 3000Hz~8000Hz. The tinnitus loudness-matched frequencies ranged form 0dB to 2 0dB, in which 45.6% of them were 5~10dB. There was no difference in Ⅰ~Ⅴ interval between the tinnitus ears and normal ears.  Conclusion   The clinical characterisitics of 162 tinnitus patients with normal hearing were identified in order to facilitate the further management. The relationship between the inner ear micro-circulation and tinnitus could not be attributed to the tinnitus in  patients with normal hearing.

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    JIANG Yi1, LIU Yun-liang2, LIU Fang1, CHEN Juan1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  10-11. 
    Abstract ( 1105 )   PDF (934KB) ( 1555 )   Save
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    ZHANG Le1, ZHU Fu-gao1, SUN Mei-hong2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  12-14. 
    Abstract ( 901 )   PDF (909KB) ( 1478 )   Save
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    YANG Li-jun1, ZHAO Long-zhu2, LONG Shun-bo2, SHAN Xi-zheng2, LI Jian-rui1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  15-16. 
    Abstract ( 1131 )   PDF (931KB) ( 1404 )   Save
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    Expressions and implication of ABCG2 and NF-κB p65 in hypopharyngeal cancer
    SHEN Bin, DONG Pin, YING Xin-jiang, GAO Shang, LI Da-wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  17-20. 
    Abstract ( 1331 )   PDF (1232KB) ( 1317 )   Save
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     Objective   To investigate  expressions and implications of breast cancer resistance protein (BCRP/ABCG2) and NF-κB p65 in hypopharyngeal cancer. Method   SP immunohistochemical technique was used to detect  expressions of ABCG2 and NF-κB p65 in the samples of 40 hypopharyngeal cancers and 10 normal hypopharyngeal mucosa. Results   Positive expressions of ABCG2 and NF-κB p65 were found in 65.0% and 72.5% hypopharyngeal cancer, respectively, which were significantly higher than those in normal hypopharyngeal mucosa(P<0.05). Positive expression of ABCG2 was significantly correlated with lymph node metastasis (P<0.01). Expression of NF-κB p65 was positively correlated with clinical stage, differentiation level or lymph node metastasis (P<0.05), but not with patient′s gender or age. Furthermore, positive expression of ABCG2 was significantly correlated  with expression of NF-κB p65 (P<0.01). Conclusion   In hypopharyngeal carcinoma, ABCG2 and NF-κB p65 are over-expressed. There is significant correlation between  expressions of ABCG2 or NF-κB p65 and lymph nodes metastasis, which implies that both play important roles in enhancing metastasis, proliferation and multidrug resistance of hypopharyngeal carcinoma.

    Diagnosis and management of eosinophilic lymphoid granuloma in the head and neck
    LIU Bin, JIANG Kai-ling, JIANG Yu-ling
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  21-23. 
    Abstract ( 1727 )   PDF (1223KB) ( 1218 )   Save
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    Objective   To systematically analyze the pathological and clinical features of eosinophilic lymphoid granuloma(ELG)to improve the diagnosis and treatment. Method   The clinical data of 10 cases of ELG were reviewed. Results   Of all the 10 cases, there were 6 males and 4 females, with ages between 29 and 59. Among the 10 cases,the typical clinical presentation was  painless soft tissue masses predominantly in the parotid and submaxillary region and combined with peripheral eosinophilia. The pathological findings  were the marked infiltration of eosinophil,lymphocytic proliferation,lymphatic follicles,variable degrees of fibrosis and vascular proliferation.Conclusion   ELG is a chronic inflammatory disease which features distinctive clinical as well as histological characteristics.  Treatments include surgery, medication and radiotherapy.

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    CHEN Gang, ZHAO Hua, JING Jian-jun, WEN Ni-re, ZHENG Liang, YAN Rui, LI Shu-hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  24-26. 
    Abstract ( 1013 )   PDF (1070KB) ( 1015 )   Save
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    SUN Hai-ying1, WANG Zhi-bin2, YU Yang2, LI Da3, CUI Xin3
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  27-29. 
    Abstract ( 1239 )   PDF (1611KB) ( 1460 )   Save
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    MIAO Bei-ping1, ZHANG Rui-shi2, SUN Huan-ji1, XIANG Deng1, SUN Yan-hua3, LU Yong-tian1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  30-33. 
    Abstract ( 1288 )   PDF (1408KB) ( 1464 )   Save
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    WANG Qiang, SONG Xi-cheng, JIANG Shao-hong, LIU Zhong-lu, CHEN Xiu-mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  34-35. 
    Abstract ( 1127 )   PDF (933KB) ( 1331 )   Save
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    XIE Jia, YAN Yong-yi, YU Feng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  36-38. 
    Abstract ( 962 )   PDF (911KB) ( 1321 )   Save
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    TONG Jun, CAI Xun-hua, CHEN Wen-wen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  39-40. 
    Abstract ( 971 )   PDF (972KB) ( 1362 )   Save
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  41-41. 
    Abstract ( 1293 )   PDF (871KB) ( 1136 )   Save
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    Radiofrequency ablation combined with endoscopy for nasal inverted papillomo
    LIU Ji-yuan, SHE Zhi-qiang, LONG Zeng-yong, LU Ling-juan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  42-43. 
    Abstract ( 2093 )   PDF (895KB) ( 1659 )   Save
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    Objective   To anaylze the clinical effect of radiofrequency ablation combined with endoscopy for nasal inverted papillomo(NIP). Methods   The clinical data of 23 cases of NIP treated by radiofrequency ablation combined with endoscopy from 2007 to 2010 were retrospectively analyzed. Results   Followed up for 6 months,  nasal obstruction disappeared and nasal ventilation was obviously improved. No patient had septal perforation and nasal deformity after the operation, and no complications occurred. Conclusion   Radiofrequency ablation combined with endoscopic is a safe and reliable method for NIP.

    Treatment for recurrent sinusitis and nasal polyps
    ZHANG Yao-li, WANG Da-quan, FU Wei, QIU Chuan-xian.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  44-45. 
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    Objective   To investigate the efficacy of comprehensive treatment for recurrent sinusitis and polyps. Methods   Thirty-one patients with recurrent sinusitis and nasal polyps underwent endoscopic sinus surgery, peri-operatively used antibiotics and oral corticosteroids, and were subjected to periodic reviews. Results   25 patients were cured, 6 were improved. Conclusion   Sinus adhesion, allergic mucosal edema, and residual lesion are major causes of recurrent sinusitis and nasal polyposis. Post-operative therapy with oral desensitization drugs and macrolides is good in long-term effect.

    Balloon catheter dilation technology in combination with fibrolaryngoscope in treating sinus cyst
    XIAO Jian-xin, CHEN Rui-kai, HE Bi-yi, CHEN Wei-xiong, WANG Yue-jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  46-48. 
    Abstract ( 1358 )   PDF (1073KB) ( 3333 )   Save
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    Objective   To evaluate the effect of nasal endoscopic sinus surgery and balloon catheter dilation technology in combination with fibrolaryngoscopy in treating sinus cyst. Methods   The clinical data of 14 cases (19 maxillary sinuses, 3 frontal sinuses) using the balloon catheter dilation technology in combination with fibrolaryngoscopy (the balloon group) and 16 cases (23 maxillary sinuses, 8 frontal sinuses) using conventional nasal endoscopic sinus surgery (the conventional group) were retrospectively analyzed. Visual analog scale (VAS) was used to record operative difficulty grade and operation time. Nasal endoscopy, coronal sinus CT scanning, Lund-Kennedy endoscopy and Lund-Mackay CT scan staging scores were used to evaluate the post-operative prognosis. Results   The balloon group was longer in operative time than the conventional group (P<0.001). During follow-up periods of  8 and 24 weeks after the operation, the sinus ostia were patency, and the nasal cavities recovered well. Conclusion   In the sinus cyst operation, the balloon group and the conventional group  equally  achieve good curative effects. In the balloon group, the nasal cavity and sinus structures can be preserved with  minimal invasion, but the operation is more difficult and longer than those in the conventional group, due to the fibrolaryngoscope.

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    DING Zan, LI Na
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  49-50. 
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    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  51-51. 
    Abstract ( 1024 )   PDF (872KB) ( 1083 )   Save
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    ZHOU Peng, HE Qing-qing, ZHUANG Da-yong, ZHENG Lu-ming, XI Chen-hui, DUAN Song-jian, CAO Lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  52-54. 
    Abstract ( 1056 )   PDF (950KB) ( 1578 )   Save
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    GONG Xiang-rong, WANG Gui-sheng, YANG Guo-jian, SUN Yan-qing, CUI Hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  55-57. 
    Abstract ( 904 )   PDF (904KB) ( 1476 )   Save
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    Application of ocular response analyzer in the intraocular pressure measurement
    JIANG Yang1, QIU Jia-ji2, JIN Yu-mei1, LI Ying1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  58-60. 
    Abstract ( 1116 )   PDF (1025KB) ( 1536 )   Save
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    Objective   To compare ocular response analyzer(ORA), goldmann applanation tonometer(GAT)and non-contact tonometer (NCT)in the intraocular pressure measurement. Methods   The patients were recruited as the normal group(168 eyes), the glaucoma group(62 eyes) and the post-refractive-surgery group (102 eyes). The intraocular pressure and the central corneal thickness(CCT) of all patients were measured by ORA and A-type ultra-sonography. The intraocular pressure of the normal group and the post-refractive-surgery group was measured by NCT  and GAT in the glaucoma group. Results   In the normal group and the post-refractive-surgery group, NCT value was (17.44±3.53) mmHg and (13.91±4.99) mmHg respectively. In the glaucoma group, GAT value was (18.90±3.74) mmHg. In all three groups, ORA values were(18.33±4.00) mmHg, ( 19.91±4.44) mmHg and (16.69±5.24) mmHg)respectively. ORA values were higher than NCT or GAT value in all groups. There were medium-level correlations between CCT value and NCT value in normal group and post-refractive-surgery group(r=0.466,0.472).There was a medium-level correlation between CCT values and GAT value in the glaucoma group (r=0.434).There was a low-level correlation between CCT value and ORA value in all groups(r=0.258, 0.221,0.249). Conclusion   Compared with the goldmann applanation tonometer and non-contact tonometer, ORA can provide more accurate  IOP value and be less influenced by corneal factors.

    Minimally invasive surgery for severe hyphema(black ball) with vitrectomy devices
    QIAO Gang, JIANG Shi-huai, DAI Yan, WANG Xiao-li, ZENG Jian, YU Min
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  61-63. 
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    Objective   To assess the effect of routine surgery and  minimally invasive surgery with vitrectomy devices for severe hyphema(black ball).   Methods   28 patients who suffering from severe hyphema(black ball) from January 2010 to December 2011 were divided into two groups. The group A (15 patients,15eyes) were cured by routine surgery and the group B were cured by minimally invasive surgery with vitrectomy devices. Regression time of the corneal edema after surgery, vision, rate of rehaemorrhagia, complicated cataract and intraocular hypertension were  recorded for analysis. Results   The regression time of the corneal edema after surgery was (5.1±1.5)days in group A and (3.1±1.3)days in group B. The vision was 4.02±1.12 and 4.65±0.21 on 3 and 7days after surgery in group A, but was 4.62±1.18 and 4.91±0.17 in group B. There were 4 cases of rehaemorrhagia and 4 complicated cataract in group A but none rehaemorrhagia and 1 complicated cataract in group B, and the differences were statistical. There were no differences in rate of intraocular hypertension  between the two groups. Conclusion   Minimally invasive surgery with vitrectomy devices for severe hyphema(black ball) can made patients less impairment and obtain better vision.

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    LIU Yun-xia, HU Hai-peng, ZHANG Xiu-ping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  64-65. 
    Abstract ( 1017 )   PDF (934KB) ( 1688 )   Save
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    Earlier panretinal photocoagulation for heavy typeⅡoptic disc vasculitis
    ZHANG Yi-xia, YANG Wei, QIU Ming-lei, CHEN Ning-ning
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  66-68. 
    Abstract ( 1195 )   PDF (910KB) ( 1478 )   Save
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    Objective   To evaluate the therapeutic effect of panretinal photocoagulation(PRP) on heavy typeⅡoptic disc vasculitis(ODV) in its early stage. Methods   25 hospitalized patients(25 eyes)with heavy typeⅡODV were randomized into the routine treatment group (n=13) and the earlier laser treatment group (n=12). The routine treatment group was treated by PRP after iris neovascularization could be observed and earlier laser treatment group began PRP treatment 2 weeks after the onset of the illness. All patients in the two groups were treated by corticosteroid and other medicines to improve microcirculation and nerve nutrition. All patients were followed up for 1 year to observe visual acuity, vision field, intra ocular pressure, iris neovessels, optic disc and fluorescence fundus angiography. Results   The visual acuity in the earlier laser treatment group was notably improved than in the routine treatment group during the follow-up. The neovascular glaucoma rate in the earlier laser treatment group was markedly decreased than in the routine treatment group. Conclusion   Earlier PRP for patients with heavy typeⅡODV can enhance the vision and reduce complications, especially for neovascular glaucoma.

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    ZHANG Xiu-ping, HU Hai-peng, LIU Yun-xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  69-71. 
    Abstract ( 955 )   PDF (1392KB) ( 1849 )   Save
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    ZHANG Xuan1, CHEN Lin2, WANG Jian-qiang1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  72-74. 
    Abstract ( 925 )   PDF (903KB) ( 1441 )   Save
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    Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery
    QIN He, SUN Jian-jun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  75-77. 
    Abstract ( 922 )   PDF (903KB) ( 1711 )   Save
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    The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery.

    Immunologic mechanism of cytokines in otitis media with effusion
    MA Hui-qin, ZHANG Zhi-jun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  78-81. 
    Abstract ( 1115 )   PDF (916KB) ( 1097 )   Save
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    There were a lot of researchs performed on the immunologic mechanism related to otitis media with effusion(OME) at home and abroad in the recent years, especially the type I allergy, cytokines related to Th1/Th2 , the interactions among these cytokines  and tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ), nuclear transcription factors kappa B (NF-kB), oxygen radicals, hypoxia inducible factor-1α(HIF-1α), transforming growth factor-β(TGF-β), or intercellular adhesion molecule (ICAM). The progress was reviewed and some new ideas is to be proposed in this paper. 

    Papillary microcarcinoma: genes and markers
    CHAI Ji-xin, HE Qing-qing, ZHUANG Da-yong, ZHENG Lu-ming, ZHOU Peng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  82-86. 
    Abstract ( 921 )   PDF (930KB) ( 1341 )   Save
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    Epidemiological study suggests that incidence rate of papillary microcarcinoma be increasing and be correlated with age, gender, racial differences, environmental factors, family history, cancer genes, etc. In this article, we reviewed the cancer genes and cancer markers relating to papillary microcarcinoma.

    Self-care external auditory canal foreign body removal device
    ZHENG Kuan-yi1, WU Jia-hui2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  87-87. 
    Abstract ( 1116 )   PDF (924KB) ( 1496 )   Save
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    A case of Kimura disease
    HUANG Yu-lin, LIANG Jian-gang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  89-90. 
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    Chronic sinusitis with diffuse panbronchiolitis: a case report
    HUANG Jue, FANG Fang, ZHANG Zuo-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  91-92. 
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    One case of renal hypertensive retinopathy first examined in ophthalmology
    HU Hai-lin, ZHU Hong, SHI Cai-hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2012, 26(4):  93-94. 
    Abstract ( 1332 )   PDF (947KB) ( 1116 )   Save
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