Table of Content

16 June 2014 Volume 28 Issue 3

  

Influence of 18-βglycyrrhetinic acid on mitochondria of nasal mucosa epithelial cells in rats with allergic rhinitis

DONG Ming1, CHEN Xiao-wan1,2, XI Ke-hu1,2, WANG You-hu1,2, GUI Yan1,2, ZHANG Fu-hong1,2, MA Chun-xia1, HONG Hao1, LIU Xiang-yi2, JIANG Ying1, MA Yi1, YANG Gui-jun1, ZHANG Xiao-bing1,2.

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  1-6.  doi:10.6040/j.issn.1673-3770.0.2014.062

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Objective    To observe the mitochondria dynamic changes of nasal mucosa epithelial cells in rats with allergic rhinitis and the influence of 18β- glycyrrhetinic acid on them. Methods    Ninety-six Wistar rats were randomly divided into 4 groups: the normal group， the model group， the loratadine group and the glycyrrhetinic acid group．AR models were established by ovalbumin and each group was respectively treated subsequently. After 2 weeks， 4 weeks， 6 weeks and 10 weeks，the ultrastructure changes were observed and compared. Results    Mitochondria in the model group showed that the number of Mitochondria increased， crest disappeared，  volume swelled or even cavitated and autophagy could be found. With persistent allergen exposure，the morphological changes aggravated gradually in the model group，meanwhile the changes in the glycyrrhetinic acid group(mentioned above in the model group)were improved and the mitochondria were much closer to the normal group with the extension of observation. Conclusion    Mitochondria ultrastructure changes of nasal mucosa ciliated epithelial cells in the rat with AR exacerbated gradually due to persistent exposure to allergen and 18β-glycyrrhetinic acid is effective to relieve the mitochondria ultrastructure changes.

Effect of lysed Enterococcus faecalis FK-23 (LFK) on serum IL-12 in allergic rhinitis mice

ZHANG Qing-zhao1, SHIMADA Takashi2, CHENG Lei1

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  7-9.  doi:10.6040/j.issn.1673-3770.0.2014.154

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Objective    To observe the effect of the heat-treated and lysed Enterococcus faecalis FK-23 (LFK) on serum levels of IL-12 in a murine model of allergic rhinitis (AR), and to discuss the anti-allergic effect of LFK on experimental AR. Methods    A total of 75 BALB/c mice were divided into three groups: 1) positive control group, 2) LFK-treated group, and 3) negative control group. To establish the murine AR model, intraperitoneal injection and nasal drip with ovalbumin (OVA) were performed. Saline was used instead of OVA for negative control mice. Probiotic preparation of LFK was orally administrated in a process of 21 days (60mg/0.5mL/mouse per day) in LFK-treated mice. The positive and negative control mice received saline orally for 21 days. The IL-12 levels were quantified in serum using ELISA on day 22. Results    Serum levels of IL-12 were significantly decreased in the positive control group than those in the negative control group (P＜0.001), and significantly increased in the LFK-treated group than those in the positive control group (P＜0.001). However, serum levels of IL-12 were still significantly decreased in the LFK-treated group compared to the negative control group (P＜0.001). Conclusion    LFK, an Enterococcus probiotic preparation, has certain modulatory actions on cytokine IL-12, which might be related to its anti-allergic effect.

Prevalence analysis of skin prick tests with aeroallergens in Tianmen district

HE Ben-chao, XU Bi-sheng, CHENG Qi, HU Jing, LI Jian-yong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  10-12.  doi:10.6040/j.issn.1673-3770.0.2013.357

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Objective    To evaluate the common allergens in Tianmen patients with allergic rhinitis and the distribution of allergic rhinitis in people of Tianmen. Method    All suspected allergic rhinitis cases underwent  skin prick tests with 11 kinds of aeroallergens. Results    Among all the patients, the positive skin reaction rate was 87%. The positive rate of Dermatophagoides pteronyssinus(Der p)was the highest， then followed up by Dermatophagoides farinae(Der f), Blomia tropicalis，Blatella germanica, dog hair. Most of patients who were positive reactivity in mites were concomitant reactivity to multiple allergens. There was no difference in the positive rates of skin reaction between males and females, but there was statistical significance between the adult and the children(P<0.05). Conclusion    Mite is the most prevalent allergen in Tianmen. The male and female had no difference in positive rates of skin reaction, and children have higher allergic positive rates than the adult.

Quality of life in patients under care of sublingual immunotherapy

WANG Xiao-ye, YOU Jian-qiang, QIU Jian-he

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  13-15.  doi:10.6040/j.issn.1673-3770.0.2014.078

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Objective    To evaluate the quality of life in patients under care of sublingual immunotherapy. Methods    Quality of life in 49 patients who were sensitized to house dust mites and treated with Dermatophagoides farinae drops in a duration of 1.5 to 2 years with complete clinical data was retrospectively analyzed． Mini rhinoconjunctivitis quality of life questionnaire(MiniRQLQ) and the total medication score(TMS)were evaluated before and half a year， 1 year and 1.5-2 years after SLIT treatment. Results    After SLIT treatment of 1 year， the scores of domains of activity limitations and other symptoms were lower than before(Z=-3.595，-5.949， P<0.05). The other domains and the total scores significantly decreased after SLIT treatment of half a year(Z=-3.854，-4.732，-2.903，-4.149， P<0.05). As time went on, the scores of MiniRQLQ dropped further. Conclusion    The nasal symptoms (sneezing, stuffy blocked nose and runny nose ) and the practical problems(need to rub nose/eyes, need to blow nose repeatedly ) were significantly affected. SLIT can improve the QOL of patients with allergic rhinitis.

Efficacy of specific sublingual immunotherapy with dermatophagoides farinae drops on allergic rhinitis and adenoid hypertrophy in children

YUE Yao-guang, HUANG He-yin, HUANG Li-fang, LIANG Shi-cai, MENG Zhou-jun, DENG Si-min, ZHANG Yong-qiang, L Xian-lin, LI Yi-hua, SHEN Cheng

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  16-19.  doi:10.6040/j.issn.1673-3770.0.2014.071

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Objective    To explore the relationship between allergic rhinitis and the pathogenes of adenoid hypertrophy in children, and to explore the specific sublingual immunotherapy effect on both diseases. Methods    92 cases of allergic rhinitis with adenoid hypertrophy were involved in the study, which were divided into two groups accepting dermatophagoides farinae drops specific sublingual immunotherapy (the research group) or routine treatment of anti-allergic drug (the control group), respectively．After 3 and 6 months of treatment in the research group and 3  months in the control group， nasal allergies, sleep snoring and changes of adenoid were observed and applied to evaluate the treatment effect.  Results    1. After treatment, VAS scores of nasal allergies and sleep snoring in the two groups were lower than those before the treatment, and sleep snoring VAS score of the control group was lower than that of the research group (P<0.05). 2. The adenoid A/N ratios of the two groups after treatment was lower than those before the treatment, and that of the control group was less than that of the research group (P<0.05). Conclusion    There is a close relationship between allergic rhinitis and adenoid hypertrophy in children. Specific sublingual immunotherapy could improve the nasal allergy symptoms, at the same time, sleep snoring improved as a result of reducing the adenoid volume, provides a new method for non-surgical treating allergic rhinitis with adenoid hypertrophy.

Efficacy and safety evaluation of radiofrequency ablation in the treatment of perennial allergic rhinitis with bronchial asthma

LIANG Fei, LIN Qing-qiang, LIU Jun-ping

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  20-22.  doi:10.6040/j.issn.1673-3770.0.2014.137

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Objective    To investigate the efficacy and safety of low-temperature plasma radiofrequency ablation for bronchial asthma with perennial allergic rhinitis. Methods    A total of 80 cases were divided into two groups: the observation group of 40 cases with radiofrequency ablation and the control group of 40 cases with microwave treatment. Results    After treatment, the total effective rate of patients with bronchial asthma and perennial allergic rhinitis was 90% and 95% respectively in the observation group, which was significantly higher than that in the control group (P<0.05). The score was lower in rhinoconjunctivitis quality of life questionnaire (RQLQ), visual analogue scale (VAS) and higher in adult asthma quality of life questionnaire (AQLQ) in the observation group than in the control group (P<0.05). Conclusion    Radiofrequency ablation has significant effect for bronchial asthma with perennial allergic rhinitis, greatly improves the quality of patient life, and it is worthy of clinical application.

Expressions and relativity of COX-2 and EGFR in nasopharyngeal carcinoma

ZHANG Xiao-peng1, BIAN Feng2, WANG Li-xin2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  23-27.  doi:10.6040/j.issn.1673-3770.0.2013.306

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Objective    To evaluate the expressions and relativity of COX-2 and EGFR in nasopharyngeal carcinoma(NPC). Methods    The expressions of COX-2 and EGFR in 86 cases of NPC, 80 cases of chronic rhinitis and 30 cases of healthy persons were detected by the immunohistochemistry and ELISA methods.    Results    The positive expression rates of COX-2 were 87.9%, 73.3% and 43.3%, and the positive expression rates of EGFR were 84.8%, 78.3% and 50% respectively in the NPC group, chronic rhinitis group and healthy group. The expressions of COX-2/EGFR in NPC were significantly higher than those in the control group. The level of COX-2/EGFR in NPC was significantly higher than in healthy persons (P=0.022, P=0.017) in serum; COX-2/EGFR had significant difference in expression of different clinical stages, there are positive correlation between the expression of COX-2 and EGFR in NPC (r=0.558, P=0.021). Conclusion    These results demonstrate high expressions of COX-2 and EGFR may involve in the pathogenesis and progression of nasopharyngeal carcinoma.

Clinical analysis of nasopharyngeal carcinoma in pregnancy

SHI Da-zhi1, LI Jian-ming2, LUO Zhi-qiang1, LUO Qin1, JING Qian-cheng1

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  28-30.  doi:10.6040/j.issn.1673-3770.0.2014.043

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Objective    To summarize the clinical data of patients with nasopharyngeal carcinoma in pregnancy and to discuss the clinical features. Methods    The clinical data of 5 cases of nasopharyngeal carcinoma in pregnancy from September 2007 to July 2012 were retrospectively analyzed. Of them, 4 were with nasopharyngeal squamous cell carcinoma and 1 with nasopharyngeal malignant myoepithelioma. Results    All 5 cases were singleton pregnancies, 3 of which (60.00%) terminated the pregnancy and induced abortion after being confirmed as nasopharyngeal carcinoma by biopsy in the pregnancy; 2 of which(40.00%) were onsets in pregnancy and confirmed by biopsy in 1 week and 1 month after delivery, and their newborns survives well. The patients with nasopharyngeal squamous cell carcinoma were treated with concomitant chemo-radiotherapy. The one with nasopharyngeal malignant myoepithelioma was treated with endoscopy in combination with the soft palate approach surgery and adjuvant radiotherapy one week after the surgery. Conclusion    Nasopharyngeal carcinoma in pregnancy and nasopharyngeal malignant myoepithelioma in pregnancy are rare. Because of the limitation of examination and medication, treatment should be based on the comprehensive consideration about the nature and clinical stage of tumor and patient preference. The long-term follow-up is also necessary to the patients and their offspring.

Clinical observation on improved nasal endoscopic plasty of inferior turbinate

ZHOU Yi-bo, YAN Yong-yi

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  31-33.  doi:10.6040/j.issn.1673-3770.0.2014.072

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Objective    To investigate the effectiveness and operation skills in improved plasty of the inferior turbinate. Methods    Totally 114 cases of chronic hypertrophic rhinitis were randomly grouped. The 57 cases of group A were treated by improved plasty of inferior turbinate, and the other 57 cases of group B were treated by submucous turbinate resection with a micro-suction cutter. Results    The post-operative nasal resistance value and VAS scores were significantly lower than the pre-operative ones(P<0.05); There was no statistical significance between the two groups in comparing pre-operative and post-operative 1 month nasal resistance value and VAS scores (P>0.05), but there was  after post-operative 1 year (P<0.05); There was no significant difference in recent and forward curative effect in group A(P>0.05), but there was in group B (P<0.05) . Conclusion    The improved plasty of inferior turbinate can result in better forward curative effect than the submucous turbinate resection with a micro-suction cutter, and it is ideal in improving chronic hypertrophic rhinitis.

Expression and significance of IL-15mRNA in nasal polyps

QIN Jie-sheng1, WANG Hui-ge1, LIN Xin-qiang1, HONG Liang-li2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  34-37.  doi:10.6040/j.issn.1673-3770.0.2014.055

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Objective    To investigate the expression of IL-15mRNA in nasal polyps and its relation with Bcl-2 and Bcl-XL and to find out the source of IL-15 in nasal polyps and its role in nasal polyps. Methods    The in situ hybridization(ISH) method was used to detect the expression of IL-15mRNA in nasal polyps and inferior nasal concha. Immunohistochemistry was used to detect the expressions of Bcl-2 and Bcl-XL in nasal polyps and inferior nasal concha. Results    The expression of IL-15mRNA in nasal polyps was higher than that in inferior nasal concha (P<0.05), so did the Bcl-XL expression(P<0.01). The expression of Bcl-2 was not significant between the nasal polyps and the inferior nasal concha. The expressions of IL-15mRNA and Bcl-XL were positively correlated with each other. Conclusion    IL-15 may play an important role in the pathogenesis of nasal polyps by inhibiting the apoptosis of eosinophlis and other inflammatory cells, which maybe do by up regulating the expression of Bcl-XL by the way of autocrine or paracrine.

Hypertonic saline solution of Pulmicort respules in post-operative recurrence of chronic sinusitis and nasal polyps after functional endoscopic sinus surgery

XU Li-na1,2, LUAN Jian-gang1, SONG Xi-cheng1, LI Yang3

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  38-41.  doi:10.6040/j.issn.1673-3770.0.2014.102

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Objective    To evaluate the clinical effect of the 3% of hypertonic saline solution of Pulmicort respules in treatment of post-operative recurrence of chronic sinusitis and nasal polyps after functional endoscopic sinus surgery (FESS) accompanied with allergic rhinitis. Methods    Nasal lavage of this drug was performed one time per day lasting 3 to 5 weeks. Results    Of the 30 cases in the treatment group, 20 cases were cured, 8 cases were improved and 2 cases were invalid. Of the 20 cases in the control group, 4 cases were cured, 8 cases were improved, and 8 cases were invalid. Conclusion    3% hypertonic saline solution of Pulmicort respules is safe and effective in treatment of post-operative recurrence of chronic sinusitis and nasal polyps after FESS accompanied by allergic rhinitis.

Analysis of sound pressure level parameters of snoring sounds in patients with obstructive sleep apnea-hypopnea syndrome and simple snoring

PENG Hao, XU Hui-jie, HUANG Wei-ning, GAO Zhan, HE Yu-xia, HU Chang-yong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  42-46.  doi:10.6040/j.issn.1673-3770.0.2014.173

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Objective    To investigate the characteristics and clinical values of sound pressure level (SPL) of snoring sounds in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and simple snoring (SS).　Methods    45 patients with OSAHS and 20 patients with SS underwent polysomnography and simultaneously snoring SPL recording. Equivalent continuous sound level A (LAeq), peak level (Lpeak) and cumulative percent level (L10, L50 and L90) of the 7 hour-snoring were subtracted, and the correlations with AHI, BMI and age were analyzed.　Results    The differences of LAeq and L10 between snoring sounds of SS and OSAHS were statistically significant. Positive correlation was found between AHI and LAeq, Lpeak, L10 with the coefficients of 0.676， 0.457 and 0.653 respectively. BMI was positively correlated to LAeq and L10 with the coefficients of 0.341 and 0.379 respectively. Age was negatively correlated to LAeq and the coefficient was -0.279.　Conclusion    1. The SPL parameters of overnight snoring sounds are affected by AHI, BMI and age of patients, among which the effect of AHI is the greatest. LAeq and L10 of the snoring sounds have the strongest correlation to AHI. 2. LAeq and L10 are important acoustic characteristics of snoring sounds. It appears that they may have clinic value on roughly distinguish OSAHS from SS and evaluate the severity of OSAHS.

Anterior semicircular canal benign paroxysmal positional vertigo in 41 patients

WANG Xue-hai, ZHANG Jian-xin, MENG Zhao-jin, LIU Xiu-ling

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  47-50.  doi:10.6040/j.issn.1673-3770.0.2014.135

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Objective    To explore the diagnosis and the efficacy of canalith  respositioning procedure(CRP) in patients with paroxysmal positional vertigo (BPPV) of anterior semicircular canal (ASC). Methods    In this research, a retrospective study of 41 patients with ASC-BPPV was performed, then the positioning tests and the CRP were analyzed. Results    In 28 individuals (68.3%) presented typical positional nystagmus during the positioning test for PSC-BPPV under the BPPV diagnosis and therapy system, 19 individuals had torsional nystagmus component and 9 individuals only had pure positional down beat nystagmus. In 35 individuals (84.6%) presented typical positional nystagmus during the positioning test for SSC-BPPV, 30 individuals had torsional nystagmus component and 5 individuals only had pure positional down beat nystagmus. In 38 patients had unilateral lesion, 30 were judged by torsional nystagmus component, 3 with pure positional down beat nystagmus but without torsional component were judged by the unilateral nystagmus and 5 with bilateral pure positional down beat nystagmus but without torsional component were judged by the obvious different strength of the vertigo and nystagmus, and 3 patients were difficult to judge the affected side.  In 38 patients had unilateral lesion, 23 were with the left AC involvement and 15 were with the right AC involvement. By once treatment, 28 patients were cured, 12 were improved and 1 was invalid. Conclusion    BPPV diagnosis and therapy system should be recommended for its exact curative effect in the process off diagnosis and treatment of BPPV.

A clinical analysis of 30 cases of children endogenous bronchial foreign bodies

ZHAO Li-min1， GU Mei-zhen1， LI Xiao-yan1， WANG Zhi-nan2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  51-52.  doi:10.6040/j.issn.1673-3770.0.2014.166

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Objective    To explore the clinical characteristics, summary diagnosis and treatment of endogenous bronchial foreign body by rigid bronchoscopy and some cautions in operation. Method    30 cases of endogenous bronchial foreign body treated by rigid bronchoscopy were retrospectively analyzed. Results    All the bronchial foreign bodies, including 25 cases of sputum, 4 cases of granulation and 1 case of pseudomembranous were successfully removed by rigid bronchoscopy. 29 cases were discharged and 1 case suggesting tuberculosis infection by post-operative examination was transfered to the tuberculosis hospital later. Conclusion    Rigid bronchoscopy is effective for diagnosis and treatment of endogenous tracheo-bronchial foreign body, but the operation must be performed gently, carefully and precisely. Observation of the general condition of patients is the key to reduce complications.

Diagnosis and treatment of tracheobronchial foreign bodies in 180 cases

CHEN Jing1， WEI Xu-dong2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  53-55.  doi:10.6040/j.issn.1673-3770.0.2014.017

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Objevtive    To improve the diagnosis and treatment by analyzing the clinical characteristics of tracheobronchial foreign bodies in children. Methods    180 cases of tracheobronchial foreign bodies, from January 2008 to September 2013, were retrospectively analyzed. Results    Foreign matter were plant in 173 cases, metal in 2 cases, plastic in 2 cases, and unclassified in 3 cases. The foreign bodies were successfully removed through the Hopkin bronchoscope in 176 patients under surface anesthesia and through the incision of tracheotomy in the other 4 patients. Second surgery to remove the foreign body were performed in 15 cases. No post-operative complications occured. No foreign body was found in X-ray examination 3 days later after  the operation. Conclusion    History of foreign body, clinical symptoms，and peri-operative X-ray examination  are keys to diagnose foreign bodies in trachea. The surface anesthesia is a simple and effective way for the  operation, however, intubation should be done in a timely manner for severe cases.

Applied anatomy of the lateral skull base

ZHANG Tao

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  56-58.  doi:10.6040/j.issn.1673-3770.0.2013.324

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Objective    To provide anatomical understandings for the positioning and navigation of lateral skull base surgery by observing and measuring the anatomical structures of the lateral skull base. Methods    The anatomical structures and relationship among jugular bulb, internal carotid artery, and the neighbouring nerves and vessles in 10 adult corpse heads (20sides ) immersed in 10％ formaldehyde were studied. Results    Jugular bulb could be divided into protrudent or flat type. The glossopharyngeal nerve usually lied in the front of the inside of jugular bulb. Vagus nerve and the accessory nerve usually lied in the inside of it. The average distances from carotid to the tensor muscle, mandibular nerve and middle meningeal artery were  2.2mm, 6.9mm, and 6.8mm, respectively. Conclusion    In the lateral skill base, there are many large blood vessels and nerves.With the full understandings, the surgeons can avoid the unnecessary damages in surgery.

New soft one-piece PHEMA keratoprosthesis implanted into alkali burned rabbit corneas: an electron microscopy observation

WANG Qun1, BAI Hua2, TIAN Lei2, WANG Li-qiang2, HUANG Yi-fei2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  59-62.  doi:10.6040/j.issn.1673-3770.0.2014.056

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Objective    To evaluate the histopathological results of the porous skirt of new one-piece keratoprosthesis (KPros) made of PHEMA implanted to alkali burned rabbit corneas. Methods    The KPros were inserted into the lamellar pocket of alkali-burned corneas and the corneas were observed clinically, histologically and ultrastructurally at various time, and followed for up to 28 weeks. Results    Histopathologic study suggested that mild inflammatory reaction and no calcification was seen in all specimens. Fibroblasts and deposition of collagen were found in the pores of the discs two weeks after implantation and stable connection with cornea would formed by 16 weeks. TEM (Transmission Electron Microscope) results showed that abundant endoplasmic reticulum could be observed in fibroblast cytoplasm at week 4, which indicated the strong synthetic activity of fibroblast cells. Also, deposition of proteoglycans and other extracellular matrix around the material could be observed under TEM. By week 16, there were large amounts of orderly arranged collagen fiber around the material. The fibroblasts in the pores looked healthy and functionally active under TEM. Conclusion    Along with the proliferation of surrounding tissue, corneal cells could proliferate and migrate into the porous skirt of PHEMA which was implanted into alkali burned rabbit corneas. Corneal cells and other cells could also secrete extracellular matrix and promote its deposition to accelerate the formation of new organizations, and strengthen the connection between cornea and material.

Intravitreal injection of Ranibizumab for idiopathic choroidal neovascularization lesion in two courses

ZI Yu-meng1, WANG Yu2, FAN Chuan-feng2, SHU Xiang-wen2, WU Chang-long2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  63-66.  doi:10.6040/j.issn.1673-3770.0.2014.158

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Objective    To compare the effect of Ranibizumab by intravitreal injection for idiopathic choroidal neovascularization lesions (ICNV). Methods    By fundus fluorescein angiography (FFA), optical coherence tomography (OCT) examination and clinical manifestation diagnosis, 36 patients(36 cases) were diagnosed as idiopathic choroidal neovascular lesions, and based on the course they were divided into group A (duration <3 months ) and B (3 months ≤ duration <6 months) . All patients underwent routine intravitreal Ranibizumab injections. The BCVA (logMAR), refraction, intraocular pressure and dilated fundus investigation were determined.  Optical coherence tomography (OCT) was used to check the positional relationship between the lesion and the fovea and to measure CMT and FFA. Results    In comparison with before treatment, BCVA and CMT were significantly improved at 3 and 6 months after treatment (P<0.05). While on the 1, 3 and 6 months after treatment, BCVA and CMT showed no significant difference between the two groups  (P>0.05), but on 6 months, the injection time in group A (1.3±0.5 times) was lower than that in group B (2.1±1.2 times) (P<0.05). Conclusion    Intravitreal injection of Ranibizumab can quickly and effectively improve the patient condition. The earlier the treatment, the lower the injection time, the risk and the cost.

Surgical effect of infantile nystagmus syndrome with strabismus

GUO Jing-li, WANG Qi, WANG Li-hua, MA Xiang, LI Lin

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  67-70.  doi:10.6040/j.issn.1673-3770.0.2014.086

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Objective    To explore the surgical method and effect of infantile nystagmus syndrome (INS) with strabismus. Methods    In this retrospective study, we reviewed 11 cases of INS with strabismus underwent surgeries in the department of ophthalmology of Shandong Provincial Hospital affiliated to Shandong University between April 2011 and December 2012. All children were in accordance with inclusive criteria and with a minimum postoperative follow-up of 6 months. Corrected visual acuity, anomalous head postures(AHP), ocular alignment and stereoacuity were examined at both pre-operative and post-operative time. For nystagmus children with strabismus, a recession-resection procedure should be performed on the dominant fixating eye; the amount of recession-resection procedure on the nondominant eye was adjusted to account for the strabismus. Results    A total of 11 children with 6 extropic and 5 esotropic were included. The mean age was 9.0±4.7 years (range, 5 to 15 years). The mean follow-up time was 9.4±5.3 months. At last post-operative follow-up time, 5 children of AHP were cured, 9 children of  ocular alignment was orthophoria and 2 children were under-corrected; 6 children of binocular vision acuity were improved more than 2 levels, and 4 children of binocular vision acuity were improved 1 level, and only one child of binocular vision acuity had no change. Conclusion    For INS children with strabismus, surgery should be performed on the dominant fixating eye; surgery on the nondominant eye is adjusted to account for strabismus. The surgery is not only to correct AHP and ocular alignment but also to improve binocular vision acuity.

Changes of anterior chamber before and after pneumatic trabeculoplasty in primary open-angle glaucoma and ocular hypertension

GAO Dong-hong， LU Hui， LI Kai-jun， ZHANG Dong-xiang， YAO Xue

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  71-72.  doi:10.6040/j.issn.1673-3770.0.2013.237

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Objective    To evaluate the anterior chamber changes in patients with primary open-angle glaucoma and ocular hypertension before and after pneumatic trabeculoplasty (PNT) by Oculyzer. Methods    A total of 30 patients (53 eyes) with primary open angle glaucoma and ocular hypertension were included in this study. The vision， intraocular pressure(IOP) and anterior chamber were evaluated before PNT, 7 and 30 days after PNT. Results    The angle of anterior chamber was (28.32±1.31)° before PNT， and (30.64±1.43)° and (32.65±1.58)° 7 and 30 days after PNT. The IOP was (22.3±3.8)mmHg before PNT, and was degraded to (19.2±3.1)mmHg and (19.6±2.7)mmHg 7 and 30 days after PNT. The differences of the angle of anterior chamber and IOP before and after PNT were significant(P<0.05). Conclusion    The angle of anterior chamber increases after PNT. The traction of trabecular meshwork may be the probable mechanism to lower IOP in the primary open-angle glaucoma and hypertensive patients.

Ganciclovir in combination with Beifushu in treatment of herpes simplex keratitis

HAN Ping

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  73-74.  doi:10.6040/j.issn.1673-3770.0.2013.333

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Objective    To investigate the effectiveness of Ganciclovir in combination with Beifushu for herpes simplex keratitis. Methods    96 cases of single blister viral keratitis were randomly divided into the treatment group and the control group. Results    Compared with the control group, the cure cycle was shorter in treatment group. Conclusion    Local eye drops Ganciclovir in combination with recombinant bovine basic fibroblast growth factor eye-gel could shorten the course of the disease and improve the curative effect.

Evaluation of corneal flaps made by femtosecond laser Ziemer FEMTO LDV “Classic” and “Crystal Line LASIK”

ZHANG Qiu-lu, WANG Yong-hua, LI Ying, WANG Yue, LIU Jing, HU Ya-bin, XU Wen, ZHENG Yan, LIU Qian, ZHAI Chang-bin

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  75-79.  doi:10.6040/j.issn.1673-3770.0.2013.354

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Objective    To compare the effectiveness of LASIK flaps created with the Ziemer FEMTO LDV “Classic” femtosecond laser and Ziemer FEMTO LDV Crystal Line femtosecond laser. Methods    Fourier-domain optical coherence tomography (RTVue OCT) was used to measure the shapes of 120 LASIK flaps one week postoperatively in the patients created with the Ziemer “Classic” femtosecond laser (group A, 60 flaps) or the Ziemer Crystal Line femtosecond laser (group B, 60 flaps). The flap thickness was determined by 36 specified points on each flap. The regularity, uniform and accuracy of Ziemer “Classic” FS and Ziemer Crystal FS were compared. Nominal flap thickness was 110μm for two FS systems. Results    The mean flap thickness of group B was thinner than that of group A (103.09±2.38 v.s. 106.93±4.86μm; P<0.01, t-test for independent-samples). The flaps in group B were more regular than those in group A when measured from the center to the periphery. The maximum deviation from the pre-determined 110μm was 7μm in group A and  8μm in group B. Among the total 2160 measured points in 60 eyes, differences greater than 20μm were noted  in 0.13% of group A and 0.02% of group B. Conclusion    The flaps created with Ziemer Crystal Line femtosecond laser are more consistent and thinner than those created by Ziemer “Classic” femtosecond laser.

MGMT gene associated with head and neck cancer

JIA Chuan-liang1,2， ZHANG Li-jing2,3, SONG Xi-cheng2

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  80-85.  doi:10.6040/j.issn.1673-3770.0.2013.350

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As a main repair enzyme of DNA alkyl damage， the protein O6-methylguanine-DNA methyltransferase protects genes from mutation and carcinogenicity caused by alkylating. MGMT epigenetic regulation is the principal mechanism affecting its expression. There is a mutually contradictory issue of decreased expression of MGMT closely related to tumor occurrence and development and high expression resistant to alkylating chemotherapy.  Single nucleotide sequence mutation of this gene locus is possibly associated with cancer incidence risks. In this paper, MGMT gene researches of head and neck cancer were reviewed.

Progress on the pathogenesis of chronic rhinosinusitis

LIU Na, YAN Juan, LIU Tao

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  86-88.  doi:10.6040/j.issn.1673-3770.0.2014.054

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Chronic rhinosinusitis (CRS) is a common disease in the Department of Otolaryngology that is a focus and difficult problem in the long-term clinical and research. The researches in recent years have in tendency to the effect of many factors, from genetic, allergic and anatomical factors. Its etiology and pathogenesis is still not clear, which brings some difficulty to clinical diagnosis and treatment of CRS. In this study, we try to explore the pathogenesis of CRS and find out more effective method of treatment and therapeutic targets. 

Primary unilateral multifocal pleomorphic adenoma of the parotid gland: one case report and literature review

ZHOU Miao-miao, CHEN Wei-xiong, WANG Yue-jian

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  89-90.  doi:10.6040/j.issn.1673-3770.0.2013.369

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One case of acute lymphoblastic leukemia first diagnosed in department of ophthalmology

SUN Juan， ZHANG Shu-e， YANG Li-xin

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(3):  91-92.  doi:10.6040/j.issn.1673-3770.0.2013.186

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