Argonaute2蛋白及其在人类肿瘤研究中的新进展

doi:10.6040/j.issn.1673-3770.0.2016.485

摘要/Abstract

摘要： 蛋白质组学迅猛发展,越来越多与肿瘤发生发展相关的蛋白质被发现,并被应用于临床诊断。Argonaute2蛋白通过参与构成RNA诱导的沉默复合体,其自身催化及自身过表达功能,在人类肿瘤的发生发展中扮演了重要角色,逐渐成为研究焦点。就Argonaute2蛋白结构、功能及在肿瘤中的作用机制方面的研究新进展做一综述。

关键词: Argonaute2蛋白, GW182, 肿瘤, 翻译后修饰, RNA诱导的沉默复合体

Abstract: With the rapid development of proteomics, proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex(RISC), selfcatalysis and overexpression, Argonaute2 plays an important role in human tumorigenesis and progression, and is becoming a research focus. In this article, we will review the research advances on the structure, function and mechanism of Argonaute2 in tumor development.

Key words: GW182, Tumor, RNA-induced silencing complex, Post-translational modification, Argonaute2

中图分类号:

R767.19

张彦惠, 董频. Argonaute2蛋白及其在人类肿瘤研究中的新进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 95-99.

ZHANG Yanhui, DONG Pin. Research advances on Argonaute2 and its role in human tumors.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 95-99.

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