铁死亡与年龄相关性白内障的研究新进展

doi:10.6040/j.issn.1673-3770.0.2023.425

摘要/Abstract

摘要： 铁死亡是一种铁依赖性的、以胞内活性氧和脂质过氧化物堆积为主要特征的新型细胞死亡方式。近年来,如何通过调节细胞铁死亡来预防相关疾病的发生和发展,已成为病原学研究和治疗的热点和焦点。白内障作为全球第一大致盲性眼病,在最新的研究中发现年龄相关性白内障(age-related cataract, ARC)可被铁死亡诱导剂和抑制剂所影响,这表明铁死亡似乎存在于ARC的发生发展过程中,因此探讨铁死亡在ARC中的功能变化和具体的分子机制具有深刻的研究价值。本文着重总结了铁死亡研究的最新进展及其在ARC相关领域的发现,旨在为进一步了解其发病机制和提出治疗ARC的新靶点提供参考。

Abstract: Ferroptosis is a form of iron-dependent cell death characterized by intracellular reactive oxygen species and lipid peroxide accumulation. In recent years, preventing the occurrence and development of related diseases by regulating cellular ferroptosis has become a focal point in pathogenic research and treatment. As the leading cause of blindness globally, cataracts, particularly age-related cataracts(ARC), can be influenced by inducers and inhibitors of ferroptosis. This suggests that ferroptosis is involved in ARC development; therefore, studying the functional changes and specific molecular mechanisms of ferroptosis in ARC has significant research value. This review discusses the latest progress in the study of ferroptosis and its findings in relation to ARC, thus providing a reference for further understanding its pathogenesis and proposing novel targets for the treatment of ARC.

Key words: Ferroptosis, Age-related cataract, Lens epithelial cells, Free radicals, Ferroptosis inhibitors, Ferroptosis inducers

中图分类号:

R776.1

汪盛,黄旭东. 铁死亡与年龄相关性白内障的研究新进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 161-168.

WANG Sheng, HUANG Xudong. Recent advancements in the research on ferroptosis and age-related cataracts[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 161-168.

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