JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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〖KH+9.2mmD]FGF2 expression in olfactory epithelium of patients with dysosmia caused by chronic sinusitis

LIU Qing-hua, LI Zhi-chun, LI Rui-yu,　LIN Chang   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated First Hospital of Fujian Medical University, Fujian Institute of Otorhinolaryngology, Fuzhou 350005, Fujian, China
  • Received:2006-08-29 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: LIU Qing-hua

Abstract: To study the pathogenesis of dysosphresia in patients with chronic sinusitis, and to discuss the expression and significance of FGF2 in olfactory epithelium. Methods: There were 32 cases of chronic sinusitis in the experimental group, and 11 cases in the control group. FGF2 was examined by the method of immunohistochemistry. Results: The expression of FGF2 in the olfactory epithelium of 32 patients suffering from dysosmia was higher than in the control group(P＜0.05). Conclusion: FGF2 promotes regeneration in the olfactory epithelium, which is decreased notably at chronic sinusitis and may lead to dysosmia.

Key words: Sinusitis, Fibroblast growth factors 2, Olfactory epithelium, Dysosmia

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