JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of ABAD/HADH Ⅱ in laryngeal squamous cell carcinoma and vocal polyp

ZHANG Hui-ping,ZHANG Peng-fei,SHANGGUAN Han-jing, LAN shu-zhan   

  1. 1. Department of Otolaryngology, Affiliated First Hospital of Fujian Medical University, Fuzhou 350004, Fujian, China; 2. Department of Pathology and Pathophysiology, Fujian Medical University, Fuzhou 350005
  • Received:2006-08-10 Revised:1900-01-01 Online:2006-10-24 Published:2006-10-24
  • Contact: ZHANG Hui-ping

Abstract: To determine the expression of ABAD/HADH Ⅱ in human laryngeal carcinoma and to investigate whether their expressions relate to proliferation of laryngeal carcinoma cells. Method: Expression of ABAD /HADH Ⅱ was detected in patients with laryngeal squamous cell carcinoma or vocal polyp by immunohistochemical method. Results： ABAD /HADH Ⅱ mainly expressed in the cytoplasm of laryngeal squamous cell cancinoma cells, especially of the proliferating cells. The immunohistochemistry result indicated that the expression of ABAD /HADH Ⅱ was significantly higher in the squamous cell cancinoma than in the vocal polyp (P<0.05). Conclusion: The expression of ABAD/HADH Ⅱ in the laryngeal squamous cell cancinomatissues is significantly higher than in the normal tissues, suggesting that ABAD /HADH Ⅱ may play a role in the proliferation of laryngeal squamous cell cancinoma.

Key words: Proliferation, ABAD/HADH Ⅱβ , Laryngeal neoplasms

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