Abstract: Objective To investigate the treatment method and prognosis of fibrous dysplasia involving rhino-orbito-skull base. Methods The clinical data of 4 cases of fibrous dysplasia involving rhino-orbito-skull base treated with nasal endoscopic surgery were retrospectively analyzed. There was 1 male and 3 females aging from 5 to 17 years with a median age 13 years. Their clinical manifestations included headache, rhinorrhea, hyposmia and nasal obstruction, except of visual deterioration in 1 case. The primary sinus involved was the ethmoid (4), sphenoid (2), frontal (2), maxillary (2), and skull (1). Results All the patients were followed up of 13-123 months. The symptoms such as headache, rhinorrhea and nasal obstruction disappeared after the operation, olfactory dysfunction was better, and the nasal cavity epithelization was well. The case of visual deterioration was re-operated 4 years later because of recurrence. All the patients had no complications and had satisfied outcome. Conclusion The nasal endoscopic surgery is safe, effective and results in less injury for fibrous dysplasia involving rhino-orbito-skull base. It not only can repristinate nasal sinuses physiological function and improve clinical symptoms, but also has positive effect on prevention and treatment of complications.

Key words: Fibrous dysplasia, Orbit, Skull base, Endoscopic surgical procedures, operative, Nasal sinus