Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 111-117.doi: 10.6040/j.issn.1673-3770.0.2022.147

• 综述 • Previous Articles     Next Articles

Research progress on the relationship between mitochondrial autophagy and squamous cell carcinoma of the head and neck

SUO Anqi1, YANG Xinxin2   

  1. 1. School of Clinical Medical, Jining Medical University, Jining 272007, Shandong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of Jining Medical University, Jining 272007, Shandong, China
  • Published:2023-05-24

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Abstract: Head and neck squamous cell carcinoma(HNSCC)is among the six most common cancers worldwide. Many patients in advanced stages of HNSCC die because of tumor recurrence or resistance to chemotherapy drugs. New treatment strategies are needed to improve the prognosis of HNSCC patients. Mitochondrial autophagy is a selective form of macro autophagy which reduces oxidative stress and prevents cancer by regulating related pathway proteins or drugs, or by promoting the survival of tumor cells under some adverse conditions. Mitochondrial autophagy is the key factor to control the quality of cancer cells which is closely related to the occurrence and development of cancer. Mitochondrial dysfunction promotes cell carcinogenesis, and mitochondrial autophagy dysfunction can induce apoptosis of cancer cells. The discovery and development of new drugs has created new options in targeting mitochondria to treat tumors. Mitochondrial autophagy shows great potential for the prevention and treatment of tumors. This article reviews the regulatory mechanism of mitochondrial autophagy, relationship between mitochondrial autophagy and tumor, and prevention and treatment of HNSCC and clinical drug resistance. The aim of this study is to provide new research directions and targets for the treatment of HNSCC.

Key words: Mitochondrial autophagy, Head and neck squamous cell carcinoma, Oxidative stress, Mitochondrial dysfunction, Regulatory mechanism, Clinical resistance

CLC Number: 

  • R739.9
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