Abstract: Objective    To summarize the clinical data of patients with nasopharyngeal carcinoma in pregnancy and to discuss the clinical features. Methods    The clinical data of 5 cases of nasopharyngeal carcinoma in pregnancy from September 2007 to July 2012 were retrospectively analyzed. Of them, 4 were with nasopharyngeal squamous cell carcinoma and 1 with nasopharyngeal malignant myoepithelioma. Results    All 5 cases were singleton pregnancies, 3 of which (60.00%) terminated the pregnancy and induced abortion after being confirmed as nasopharyngeal carcinoma by biopsy in the pregnancy; 2 of which(40.00%) were onsets in pregnancy and confirmed by biopsy in 1 week and 1 month after delivery, and their newborns survives well. The patients with nasopharyngeal squamous cell carcinoma were treated with concomitant chemo-radiotherapy. The one with nasopharyngeal malignant myoepithelioma was treated with endoscopy in combination with the soft palate approach surgery and adjuvant radiotherapy one week after the surgery. Conclusion    Nasopharyngeal carcinoma in pregnancy and nasopharyngeal malignant myoepithelioma in pregnancy are rare. Because of the limitation of examination and medication, treatment should be based on the comprehensive consideration about the nature and clinical stage of tumor and patient preference. The long-term follow-up is also necessary to the patients and their offspring.

Key words: Nasopharyngeal carcinoma, Pregnancy, Treatment, Erroneous diagnosis