Abstract: Objective To evaluate the effect of short-course budesonide suspension via nasal atomization on the operation bleeding of chronic nasosinusitis accompanied by nasal polyps. Methods A total of 96 patients with chronic nasosinusitis accompanied by nasal polyps were randomly divided into group A(n=33), group B(n=31)and group C(n=32). At 7 days before the operation, group A was inhaled budesonide suspension via nasal atomization and took roxithromycin; Group B was given budesonide nasal spray and took roxithromycin; Group C was given normal saline to wash the nasal cavity and took roxithromycin. The operations were performed in 3 groups according to the unified regimen. The amount of intraoperative bleeding in 3 groups and change of serum cortisol concentrations in groups A and B were compared. Results Average amount of intraoperative bleeding in 3 groups was(51.70±18.62)mL,(73.16±19.23)mL and(90.16±15.97)mL, and there was statistical significance among 3 groups(F=37.34, P<0.01). The concentration of serum cortisol in group A decreased after administration(P<0.01), but it was still within the normal range; There was no change in group B regarding the concentration of serum cortisol before and after administration(P>0.05). Conclusion Short-course application of budesonide suspension via nasal atomization can reduce endoscopic intraoperative bleeding of patients with chronic nasosinusitis accompanied by nasal polyp and has no obvious impact on the function of adrenal cortex.

Key words: Nasal endoscopic surgical procedures, operative, Nasal polyp, Nasosinusitis, Budesonide