Abstract: Objective To investigate the factors related to the recurrence of chronic rhinosinusitis with nasal polyps(CRSwNP). Methods A total of 206 patients with CRSwNP hospitalized in our department From February 2011 to March 2014 were enrolled in this study. The clinical data were collected. The histopathological examinations of nasal polyps were taken. All the patients were followed up after the operation. Results In the following up, 115(55.8%)patients with CRSwNP were recurred and 91(44.2%)were not. The proportion of asthmatic, the proportion of Eos in peripheral blood, runny nose score, head/face pain score, olfactory damage, Lund-Mackay score and the proportion of eosinophil(Eos)in tissues in the recurrence group were higher than those in the non-recurrence group, while the proportion of neutrophils(Neu)in peripheral blood, the proportion of Neu in tissues, the proportion of lymphocytes in tissues and the proportion of plasma cells in the tissues in the recurrence group were lower than those in the non-recurrence group(P<0.05). Multivariate Logistic regression analysis showed that the proportion of eosinophils(Eos)in tissues was an independent risk factor for recurrence of CRSwNP(P<0.001). The ROC curve showed that the proportion of Eos in tissues in predicting the recurrences of CRSwNP, the area under the curve was 0.948(95% CI: 0.923-0.974). When the proportion of Eos was 18.9%, the sensitivity was 75.8% and the specificity was 98.3%. Conclusion The proportion of Eos in tissues was independent risk factor for recurrence of CRSwNP, and when the proportion of Eos in tissues was 18.9%, it had the best diagnostic value.

Key words: Nasal polyps, Chronic rhinosinusitis, Recurrence, Influencing factors