JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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ASignificance of Fas and Bcl-2 expressions in nasal polyps

ZHANG Nian-wu， MU Min-lei， YUAN Hai   

  1. Department of Otorhinolaryngology, Rizhao Hospital of Traditional Chinese Medicine,
  • Received:2006-01-16 Revised:1900-01-01 Online:2006-06-24 Published:2006-06-24
  • Contact: ZHANG Nian-wu

Abstract: Objective： To study the expressions of Fas and Bcl2 in nasal polyps and explore the relationship between the two apoptosisrelated proteins in formation of nasal polyps. Methods： Expressions of Fas and Bcl2 were detected with SP immunohistochemical method in 36 nasal polyps and 19 inferior turbinates. Results： (1) The expression of Fas in epithelial cells and epithelial cells of glands was significantly lower in nasal polyps than in inferior turbinates(P＜0.05); (2) The expression of Bcl2 in epithelial cells and epithelial cells of glands was significantly higher in nasal polyps than in inferior turbinates (P＜0.05); (3) The expressions of Fas and Bcl2 had no correlation with each other in epithelial cells of nasal polyps(P＞0.05). Conclusion： (1) Fas and Bcl2 may play important role in theoccurrence and progression of nasal polyps; (2) No relationship is found between Fas and Bcl2 in inhibiting the epithelial cells of glands of nasal polyps.

Key words: Fas, Bcl-2, Nasal polyps, Apoptosis鼻息肉

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