Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (1): 54-57.doi: 10.6040/j.issn.1673-3770.0.2019.478

Previous Articles     Next Articles

Value of NLR, LMR, and PLR in predicting chronic sinusitis recurrence after endoscopic sinus surgery

XIE Shuhua, YANG Zhumei, LIU Huiru, DONG Jing   

  1. 1. Department of Otorhinolaryngology, Shanghai Yangpu District Kongjiang Hospital, Shanghai 200093, China;
    2. Department of Otorhinolaryngology Head and Neck Surgery, Yangpu Hospital affiliated to Tongji University, Shanghai 200090, China.
  • Published:2020-03-06

PDF (PC)

384

Abstract: Objective To explore the value of the neutrophil to lymphocyte ratio(NLR), lymphocyte to monocyte ratio(LMR), and platelet to lymphocyte ratio(PLR)in predicting the recurrence of chronic sinusitis after endoscopic sinus surgery. Methods Sixty patients with chronic sinusitis treated by endoscopy from March 2016 to March 2018 were selected. All patients were followed up for 6 months and were divided into the postoperative recurrence group(n=21)and non-postoperative recurrence group(n=39)according to whether sinusitis recurred or not. In the same period, 87 people who underwent a health examination at our hospital were selected as the control group(n=87). The NLR, LMR and PLR of all patients were collected and analyzed. The receiver operating characteristic curve(ROC)of the above indicators was drawn. Results The NLR and PLR levels in the chronic rhinosinusitis(CRS)group were higher than those in the control group(p<0.05). The level of LMR in the CRS group was lower than that in the control group (p<0.01). There was no significant difference in NLR, LMR and PLR between the non-postoperative recurrence group and the control group (p>0.05). The levels of NLR and PLR in the postoperative recurrence group were higher than those in the non-postoperative recurrence group (p<0.05). The level of LMR in the postoperative recurrence group was lower than that in the non-postoperative recurrence group (p<0.01). The sensitivity and specificity of NLR were 63.33%(19/30)and 93.33%(28/30), respectively. The sensitivity and specificity of LMR were 72.00%(18/25)and 91.43%(32/35), respectively. The sensitivity and specificity of PLR were 67.86%(19/28)and 93.75%(30/32), respectively. The ROC curves showed that the areas under NLR, LMR and PLR curves were 0.719(0.587-0.851), 0.922(0.853-0.991), and 0.830(0.587-0.851), respectively. Conclusion NLR, LMR and PLR can help to predict chronic sinusitis recurrence after endoscopic sinus surgery.

Key words: Chronic sinusitis, Nasal endoscopy, Recurrence, Neutrophil, Lymphocyte, Platelet

CLC Number: 

  • R765
[1] Velasquez N, Thamboo A, Abuzeid WM, et al. Safe treatment of ethmoid sinusitis utilizing minimally invasive ethmoid punch sinusotomy in chronic rhinosinusitis without polyposis patients[J]. Laryngoscope, 2017, 127(6): 1268-1275. doi:10.1002/lary. 26493.
[2] 陈宗燕, 黄礼辉, 胡韬. 鼻内窥镜下手术治疗慢性鼻窦炎鼻息肉的疗效观察[J]. 贵州医药, 2017, 41(10): 1066-1067. doi: 10.3969/j.issn.1000-744X. 2017.10.023.
[3] 郑富春, 侯勇. 加强药物疗法联合鼻内镜手术治疗慢性鼻-鼻窦炎疗效观察[J]. 海南医学, 2017, 28(12): 1941-1943. doi:10.3969/j.issn.1003-6350. 2017.12.016. ZHENG Fuchun, HOU Yong. Clinical observation of strengthening drug therapy combined with nasal endoscopic surgery for chronic nasal sinusitis[J]. Hainan Med J, 2017, 28(12): 1941-1943. doi:10.3969/j.issn.1003-6350. 2017.12.016.
[4] Kuruvilla ME, Levy J. Efficacy of reslizumab in eosinophilic chronic sinusitis with nasal polyposis[J]. J Allergy Clin Immunol, 2018, 141(2): AB270. doi:10.1016/j.jaci. 2017.12.860.
[5] 于锋, 焦粤农, 钟胜长. 慢性鼻-鼻窦炎术后复发相关因素的多元回归分析[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(9): 737-741. doi:10.13201/j.issn.1001-1781. 2016.09.017 YU Feng, JIAO Yuenong, ZHONG Shengchang. The multiple regression analysis of related factors in chronic rhinosinusitis postoperative recurrence[J]. J Clin Otorhinolaryngol Head Neck Surg, 2016, 30(9): 737-741. doi:10.13201/j.issn.1001-1781. 2016.09.017.
[6] 中华耳鼻咽喉头颈外科杂志编委会. 慢性鼻-鼻窦炎诊断和治疗指南[J]. 中国临床医生, 2010, 38(4): 73-74.
[7] Rai G, Das S, Ansari MA, et al. Phenotypic and functional profile of Th17 and Treg cells in allergic fungal sinusitis[J]. Int Immunopharmacol, 2018, 57: 55-61. doi:10.1016/j.intimp. 2018.02.009.
[8] Wright ED, Christodoulopoulos P, Frenkiel S, et al. Expression of interleukin(IL)-12(p40)and IL-12(beta 2)receptors in allergic rhinitis and chronic sinusitis[J]. Clin Exp Allergy, 1999, 29(10): 1320-1325. doi:10.1046/j.1365-2222.1999. 00637.x.
[9] Jenks M, Willits I, Turner EE, et al. The XprESS multi-sinus dilation system for the treatment of chronic sinusitis: A NICE medical technology guidance[J]. Appl Health Econ Health Policy, 2017, 15(5): 567-582. doi:10.1007/s40258-017-0337-7.
[10] 肖四方, 潘建华, 向延根. NLR、PLR和LMR在急诊甲、乙型流感病毒感染者中的临床意义[J]. 热带医学杂志, 2018, 18(11): 1478-1481. doi: CNKI:SUN:RDYZ.0. 2018-11-019. XIAO Sifang, PAN Jianhua, XIANG Yangen. Clinical value of NLR, PLR and LMR in emergency patients with influenza A or B[J]. J Trop Med, 2018, 18(11): 1478-1481. doi: CNKI:SUN:RDYZ.0. 2018-11-019.
[11] Ying HQ, Deng QW, He BS, et al. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients[J]. Med Oncol, 2014, 31(12): 305. doi:10.1007/s12032-014-0305-0.
[12] Meng XC, Chang Q, Liu YY, et al. Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, China: A posteriori and big-data-based[J]. J Clin Lab Anal, 2018, 32(2): e22228. doi:10.1002/jcla. 22228.
[13] Rajwa P,(·overZ)yczkowski M, Paradysz A, et al. Evaluation of the prognostic value of LMR, PLR, NLR, and dNLR in urothelial bladder cancer patients treated with radical cystectomy[J]. Eur Rev Med Pharmacol Sci, 2018, 22(10): 3027-3037. doi:10.26355/eurrev_201805_15060.
[14] 张劼, 龚齐. 不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 54-57. doi: 10.6040/j.issn.1673-3770.0.2017.422. ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(3): 54-57. doi: 10.6040/j.issn.1673-3770.0.2017.422.
[15] Dine G, Ali-Ammar N, Brahimi S, et al. Chronic sinusitis in a patient with selective IgG4 subclass deficiency controlled with enriched immunoglobulins[J]. Clin Case Rep, 2017, 5(6): 792-794. doi:10.1002/ccr3.936.
[16] 徐文中, 刘春艳. 过敏性鼻炎患儿淋巴细胞亚群、血清IgE水平的变化及其相关性[J]. 中国免疫学杂志, 2016, 32(4): 550-552. doi: 10.3969/j.issn.1000-484X. 2016.04.022. XU Wenzhong, LIU Chunyan. Changes and correlation of lymphocyte subsets and serum levels of IgE in children with allergic rhinitis[J]. Chin J Immunol, 2016, 32(4): 550-552. doi: 10.3969/j.issn.1000-484X. 2016.04.022.
[17] Lennard CM, Mann EA, Sun LL, et al. Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids[J]. Am J Rhinol, 2000, 14(6): 367-373. doi:10.2500/105065800779954329.
[18] Kim YH, Kim J, Kang MG, et al. Optic nerve changes in chronic sinusitis patients: Correlation with disease severity and relevant sinus location[J]. PLoS One, 2018, 13(7): e0199875. doi:10.1371/journal.pone. 0199875.
[1] WANG Kaijian, WANG Wei, CHEN Xuesheng, FAN Chunsun, HE Yingying, HUANG Dongling, QIAN Cunhui, DING Shujun. Correlation between neutrophil-to-lymphocyte ratio with hearing loss and audiometric thresholds in adults: a cross-sectional study based on NHANES [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 18-28.
[2] DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86.
[3] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[4] LIU Nanxian, YANG Zeyin, HAN Lin, ZHANG Aiying, ZHAO Yuliang, XUE Jing, SUN Yijun, SHAO Yongliang. Significance of video-EEG in the diagnosis of recurrent vertigo in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 20-25.
[5] SHEN Bojun, LIU Suru, LI Chunyan, SU Kaiming. Investigating the impact of serum bilirubin levels on the prognosis of patients with acute epiglottitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 26-31.
[6] LI Xiaoyu, WANG Binchen, XU Dapeng, WANG Yanhua, DU Pinggong, ZHANG Qingquan. Effectiveness of transnasal and transoral fenestration in the treatment of maxillary bone cysts [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 72-78.
[7] WANG Wenqing, ZHANG Dan, ZHU Mengdi, WANG Luyang, YANG Peipei, SUN Sisi, ZHANG Qiumin, ZHOU Hui. Changes of clinical and histopathological characteristics in recurrent chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 46-53.
[8] SHI Zhonggang, CAI Xiaolan, LI Xuezhong, ZHANG Liqiang, FENG Xin. Maxillary cyst with inverted papilloma: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 123-129.
[9] ZHANG Yunqiu, REN Xiumin, XU Ou, DONG Jinhui, WANG Jianxing. Research progress on omalizumab targeted therapy for chronic sinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 136-140.
[10] LI Ting, ZHAO Chong, WU Xian. The relationship between miR-34a expression in nasal mucosa tissue and postoperative recurrence in patients with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 20-25.
[11] ZHENG Lu, CHENG Jie, OUYANG Hong, CHI Huaming, DU Jingdong. Intractable nosebleed due to haemophilia A: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 86-90.
[12] LI Meichen, CHEN Hailing, LI Yang, MA Dengdian. Mucocele of inferior turbinate: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 91-94.
[13] ZHANG Jingyi, DONG Xiangyi, MU Yakui, SONG Xicheng. Research progress on pyroptosis in otorhinolaryngology diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 140-148.
[14] LI Hongjin, WANG Jian, LAI Yubin, XU Min, XUE Tao, CHEN Fuquan, ZHA Dingjun, CHEN Xiaodong. Evaluation of different surgical methods in the treatment of maxillary cysts [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 33-37.
[15] WANG Kaijian, CHEN Xuesheng, WANG Wei. A meta-analysis of the correlation between platelet-lymphocyte ratio and prognosis of laryngeal squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 67-73.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd