Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (1): 50-53.doi: 10.6040/j.issn.1673-3770.0.2019.357

Previous Articles     Next Articles

The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma

CHEN Xuesong, FU Weiwei, LIU Jiangtao   

  1. Department of Otorhinolaryngology, Binzhou Central Hospital, Huimin 251700, Shandong, China
  • Published:2020-03-06

PDF (PC)

518

Abstract: Objective To evaluate the role of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in the prognosis of nasopharyngeal carcinoma(NPC). Methods A total of 120 patients with NPC undergoing intensity modulated radiation therapy(IMRT)from June 2012 to January 2014 were retrospectively included and their clinical information was obtained. The relationship between NLR, PLR, and overall survival(OS), progression-free survival(PFS), distant metastasis-free survival(DMFS), and local recurrence-free survival(LRF)was explored by correlation analysis, survival analysis, and multivariate regression analysis. Results The overall 5-year estimated OS, PFS, LRFS and DFS were 86.8%, 78.3%, 94.2%, and 85.3%, respectively. There was a significant association between NLR and T-stage, N-stage and tumor stage. PLR was also significantly associated with T-stage and tumor stage. NLR was shown to be an independent prognostic indicator for OS, PFS, DMFS. Conclusion NLR is an independent prognostic factor in nasopharyngeal carcinoma patients treated with IMRT.

Key words: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Nasopharyngeal carcinoma, Prognosis

CLC Number: 

  • R739.6
[1] 李晓惠, 徐冰清, 高劲, 等. 中性粒细胞与淋巴细胞比值对鼻咽癌放射敏感性及预后影响的研究[J]. 中华放射肿瘤学杂志, 2016, 25(5): 432-436. doi:10.3760/cma.j.issn.1004-4221. 2016.05.002. LI Xiaohui, XU Bingqing, GAO Jin, et al. Influence of neutrophil-lymphocyte ratio on radiosensitivity and prognosis in patients with nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 432-436. doi:10.3760/cma.j.issn.1004-4221. 2016.05.002.
[2] 徐翔, 何庆文, 肖才文. Ki67和衍生中性粒细胞与淋巴细胞比值对鼻咽癌患者的预后评估[J]. 国际肿瘤学杂志, 2018, 45(12): 711-715. doi:10.3760/cma.j.issn.1673-422X. 2018.12.002. XU Xiang. Prognostic evaluation of Ki67 and derived neutrophil-lymphocyte ratio in patients with nasopharyngeal carcinoma[J]. Journal of International Oncology, 2018, 45(12): 711-715. doi:10.3760/cma.j.issn.1673-422X. 2018.12.002.
[3] Lee AWM, Ma BBY, Ng WT, et al. Management of nasopharyngeal carcinoma: current practice and future perspective[J]. J Clin Oncol, 2015, 33(29): 3356-3364. doi:10.1200/jco. 2015.60.9347.
[4] 郑乃莹, 林先桃, 邵汛帆, 等. 吸烟与Ⅲ~ⅣA期鼻咽癌预后关系[J]. 中华肿瘤防治杂志, 2017, 24(16): 1113-1118. doi:10.16073/j.cnki.cjcpt. 2017.16.002. ZHENG Naiying, LIN Xiantao, SHAO Xunfan, et al. Relationship between smoking and prognosis of Ⅲ/ⅣA stage nasopharyngeal carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2017, 24(16): 1113-1118. doi:10.16073/j.cnki.cjcpt. 2017.16.002.
[5] 胡望远, 姜峰, 杨昕, 等. 鼻咽癌调强放疗计划后剂量分布与预后相关性研究[J]. 肿瘤学杂志, 2018, 24(8): 828-831. doi:10.11735/j.issn.1671-170X. 2018.08.B015. HU Wangyuan, JIANG Feng, YANG Xin, et al. The effect of post intensity-modulated radiotherapy dose distribution on prognosis of nasopharyngeal carcinoma[J]. Journal of Chinese Oncology, 2018, 24(8): 828-831. doi:10.11735/j.issn.1671-170X. 2018.08.B015.
[6] Lu C, Gao P, Yang YC, et al. Prognostic evaluation of platelet to lymphocyte ratio in patients with colorectal cancer[J]. Oncotarget, 2017, 8(49): 86287-86295. doi:10.18632/oncotarget. 21141.
[7] 马涛, 刘斌, 刘丽霞, 等. 局部复发鼻咽癌调强放疗的临床结果和预后因素分析[J]. 河北医药, 2016, 38(14): 2185-2187. doi:10.3969/j.issn.1002-7386. 2016.14.031.
[8] Chua ML, Tan SH, Kusumawidjaja G, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: A pooled analysis of two randomised controlled trials[J]. Eur J Cancer, 2016, 67: 119-129. doi:10.1016/j.ejca. 2016.08.006.
[9] 王勇, 吴波, 孙华丽, 等. 鼻咽癌EGFR、HLA-F表达水平及调强放疗预后的影响因素分析[J]. 浙江医学, 2019, 41(17): 1826-1830. doi:10.12056/j.issn.1006-2785.2019.41.17. 2018-2721. WANG Yong, WU Bo, SUN Huali, et al. Expression of EGFR and HLA-F in nasopharyngeal carcinoma and their prognostic value[J]. Zhejiang Medical Journal, 2019, 41(17): 1826-1830. doi:10.12056/j.issn.1006-2785. 2019.41.17. 2018-2721.
[10] Lu AY, Li HF, Zheng YM, et al. Prognostic significance of neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, and platelet to lymphocyte ratio in patients with nasopharyngeal carcinoma[J]. Biomed Res Int, 2017, 2017: 1-6. doi:10.1155/2017/3047802.
[11] Jin Y, Ye X, He CX, et al. Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma[J]. Head Neck, 2015, 37(1): 69-75. doi:10.1002/hed.23565.
[12] 宗井凤, 郑瑜宏, 翁友良, 等. 治疗前血浆EBV DNA在调强放疗鼻咽癌患者预后中的意义[J]. 肿瘤学杂志, 2016, 22(10): 810-815. doi:10.11735/j.issn.1671-170X. 2016.10.B007. ZONG Jingfeng, ZHENG Yuhong, WENG Youliang, et al. Prognostic value of pre-treatment plasma EBV DNA in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy[J]. Journal of Chinese Oncology, 2016, 22(10): 810-815. doi:10.11735/j.issn.1671-170X. 2016.10.B007.
[13] 许梅杰, 苏梅, 薛荣, 等. 阻塞性睡眠呼吸暂停程度与中性粒细胞/淋巴细胞比值的相关性研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 33-37. XU Meijie, SU Mei, XUE Rong, et al. Correlation between neutrophil/lymphocyte ratio and severity of obstructive sleep apnea syndrome[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(5): 33-37.
[14] Young CA, Murray LJ, Karakaya E, et al. The prognostic role of the neutrophil-to-lymphocyte ratio in oropharyngeal carcinoma treated with chemoradiotherapy[J]. Clin Med Insights Oncol, 2014, 8: 81-86. doi:10.4137/CMO. S15476.
[15] Farhan-Alanie OM, Mc Mahon J, Mc Millan DC. Systemic inflammatory response and survival in patients undergoing curative resection of oral squamous cell carcinoma[J]. Br J Oral Maxillofac Surg, 2015, 53(2): 126-131. doi:10.1016/j.bjoms. 2014.10.007.
[16] Selzer E, Grah A, Heiduschka G, et al. Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer: Comparative analysis of inflammation-based prognostic scoring systems[J]. Strahlenther Onkol, 2015, 191(6): 486-494. doi:10.1007/s00066-014-0803-1.
[17] 张劼, 龚齐. 不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 54-57. doi:10.6040/j.issn.1673-3770.0. 2017.422. ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 54-57. doi:10.6040/j.issn.1673-3770.0. 2017.422.
[1] LIN Xiaoxue, LIN Baorui, LI Peishan, LU Biaoqing. Application of electronic nasopharyngoscopy combined with narrow band imaging in traditional Chinese medicine syndrome differentiation of nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 40-46.
[2] MIAO Hongli, ZHANG Yanchun, HAO Linna, TANG Le, HE Yingnan. Clinical features and prognostic analysis of active ocular toxoplasmosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 82-89.
[3] PENG Zhonghua, CHEN Zhu, YUAN Luohua, YU Shaolan, MA Yuling. Primary high-grade non-intestinal-type adenocarcinoma of the nasal cavity: a case report and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 95-98.
[4] LI Zan, LU Qi, SHEN Weidong, HOU Zhaohui, WU Nan. Clinical diagnosis and treatment features of 18 cases of necrotizing otitis externa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 17-22.
[5] LIU Yuzhu, CHEN Yao, YUAN Tiejun, LI Chunsen, LI Bo. Larynx fibrosarcoma: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 133-137.
[6] WANG Sheng, LI Yindan, YANG Jinji. The role of microRNA in nasopharyngeal carcinoma and its research progress [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 125-131.
[7] QIU Qianhui, XIAO Xuping, YANG Qintai, YE Jing, DENG Zeyi, WANG Desheng, TAN Guolin, JIANG weihong,. Expert consensus on clinical management recommendations for carotid blowout syndrome secondary to NPC treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 1-18.
[8] WANG Siquan, ZHU Hongshen, ZHANG Xiaobin, ZHAO Zhouyang, MA Yue, YANG Yimei, HUANG Lijin. Analysis of factors associated with stroke and cranial nerve palsy after unilateral internal carotid artery embolization in patients with nasopharyngeal carcinoma after radiotherapy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 19-25.
[9] HUANG Qiao, REN Yi, HOU Tao, LIAO Xingwei, ZHU Zi’ang, ZHAN Xiaolin, LIU Ying, YIN Shihua. Expression of EphB2 in nasopharyngeal carcinoma tissues and its correlation with clinicopathological characteristics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 26-30.
[10] SUN Chunxiao, WANG Wenqing, YUE Tian, LIU Jisheng. Efficacy analysis of concurrent chemoradiotherapy with high and low cumulative cisplatin doses in the treatment of nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 31-41.
[11] WANG Zaixing, TANG Zhiyuan, LI Dingbo, SHI Zhaohui, ZENG Xianhai, ZHANG Qiuhang. Treatment of internal carotid artery rupture caused by tumor recurrence and skull base osteonecrosis after radiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 49-58.
[12] SUN Fang, XIE Chubo, QIU Qianhui. Retrospective analysis of nutritional indexes and their impact on wound healing in patients with radiation-induced skull base osteoradionecrosis after treatment with nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 59-68.
[13] ZHU Ruikai, WU Jiarong, SUN Fang, XIE Chubo, QIU Qianhui. Computed tomography angiography-based assessment of internal carotid artery stenosis after radiotherapy for nasopharyngeal carcinoma and its associated factors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 77-84.
[14] QIN Debo, XUE Jiancheng, YANG Wenyue, HU Bing, CHEN Tao, YU Yanping, MENG Qingguo, SUN Huanji, MIAO Beiping, LU Yongtian. Changing the diagnosis and treatment of nasopharyngeal cancer: biomarkers and nasal endoscopic surgery synergise to advance early treatment development [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 85-92.
[15] WU Jiarong, QIU Qianhui. The role and significance of the skull base fascial tissue barrier in endoscopic resection of locally early recurrent nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 108-113.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd