Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (5): 152-156.doi: 10.6040/j.issn.1673-3770.0.2019.595

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Correlation between obstructive sleep apnea and tumors

  

  • Received:2019-11-30 Published:2020-11-17

Abstract: Obstructive sleep apnea(OSA)is a chronic disease that is prevalent worldwide. The morbidity of OSA has increased year by year. The primary characteristic of OSA is repeated upper airway collapse, which causes recurrent apnea, hypopnea, and frequent decline of the oxyhemoglobin saturation. This leads to sleep fragmentation and sleep structure disorder. Patients with OSA usually suffer from daytime sleepiness and inattention. Long-term sleep fragmentation and micro-arousal state are related to many chronic diseases, such as hypertension, myocardial infarction, Type 2 diabetes and Alzheimer's disease. Moreover, OSA is also closely related to tumors. With increases in the degree of OSA and hypoxemia, the incidence and mortality of related tumors have also gone up. Such tumors include lung, breast, nasopharyngeal, prostate and central nervous system cancers. To provide a reference for OSA and tumor-related research and clinical practice and develop ideas around further treatment research that could be conducted, this article reviews the profile of OSA and the statistical evidence, moreover, the molecular mechanism and treatment of OSA related to tumors will be discussed.

Key words: Obstructive sleep apnea, Hypopnea, Tumor, Correlation

CLC Number: 

  • R766.7
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