Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (2): 28-33.doi: 10.6040/j.issn.1673-3770.1.2020.086

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Clinical analysis of low-temperature plasma radiofrequency ablation for benign tumors in the parapharyngeal space

ZHU Huaming, GUAN Jian, MAO Song, ZHANG Weitian, YI Hongliang   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital/Otolaryngological Institute, Shanghai Jiao Tong University/Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China
  • Published:2021-04-20

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Abstract: Objective To evaluate the feasibility and effect of low-temperature plasma radiofrequency ablation(LTPRA)in the operation of benign tumors in the parapharyngeal space(PPS). Methods Twenty patients with benign tumors in the PPS who underwent surgery in our hospital from January 2012 to December 2018 were analyzed. Of the 20 patients, 11(group A)were treated with LTPRA and 9(group B)without LTPRA. All the patients were thoroughly evaluated before surgery. The clinical data, pathological results, and surgical information of patients were collected. Results In this study, neurogenic tumors were the most common benign tumors in the PPS(13 cases). Six patients in group A(of 11 cases)underwent the transoral or transnasal surgical approaches. In group B, all nine patients underwent lateral approaches. Surgical complications occurred in both groups. One recurrent case was observed from group B. Conclusion Surgery for PPS tumors tends to be safe and minimally invasive. Different surgical approaches can be selected according to the location and character of the tumor. LTPRA plays an important role in the operation of PPS tumors in transoral and transnasal approaches.

Key words: Parapharyngeal space, Head and neck tumors, Low-temperature plasma, Surgery, Surgical approach

CLC Number: 

  • R739.63
[1] 胡娟娟, 洪育明. 咽旁间隙肿瘤的诊断和治疗[J]. 山东大学耳鼻喉眼学报, 2014(5): 85-90. doi:10.6040/j.issn.1673-3770.0.2014.159. HU Juanjuan, HONG Yuming. Diagnosis and treatment of parapharyngeal space neoplasms[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014(5): 85-90. doi:10.6040/j.issn.1673-3770.0.2014.159.
[2] Kuet ML, Kasbekar AV, Masterson L, et al. Management of tumors arising from the parapharyngeal space: a systematic review of 1, 293 cases reported over 25 years[J]. Laryngoscope, 2015, 125(6): 1372-1381. doi:10.1002/lary.25077.
[3] Liu XW, Wang L, Li H, et al. A modified method for locating parapharyngeal space neoplasms on magnetic resonance images: implications for differential diagnosis[J]. Chin J Cancer, 2014, 33(10): 511-520. doi:10.5732/cjc.014.10017.
[4] Basaran B, Polat B, Unsaler S, et al. Parapharyngeal space tumours: the efficiency of a transcervical approach without mandibulotomy through review of 44 cases[J]. Acta Otorhinolaryngol Ital, 2014, 34(5): 310-316.
[5] Shinohara Y, Matsumoto T, Kiga N, et al. Neurilemmoma of the Vagus Nerve in the Poststyloid Parapharyngeal Space[J]. J Clin Diagn Res, 2016, 10(1):17-19. doi: 10.7860/JCDR/2016/13789.7141.
[6] Luna-Ortiz K, Villa-Zepeda O, Carrillo JF, et al. Parapharyngeal space tumor: submandibular approach without mandibulotomy[J]. J Maxillofac Oral Surg, 2018, 17(4): 616-624. doi:10.1007/s12663-018-1133-0.
[7] Chen Z, Chen YL, Yu Q, et al. Excision of tumors in the parapharyngeal space using an endoscopically assisted transoral approach: a case series and literature review[J]. J Int Med Res, 2019, 47(3): 1103-1113. doi:10.1177/0300060518816190.
[8] Pradhan P, Preetam C, Parida PK, et al. Surgical management of parapharyngeal space tumours in a single tertiary care center[J]. Indian J Otolaryngol Head Neck Surg, 2018, 70(4): 531-537. doi:10.1007/s12070-018-1447-8.
[9] 刘方舟,董明敏,张园,等. 咽旁间隙原发肿瘤69例临床病理与解剖分析[J]. 临床耳鼻咽喉头颈外科杂志, 2009, 23(3): 113-114, 118. doi:10.3969/j.issn.1001-1781.2009.03.005. LIU Fangzhou, DONG Mingmin, ZHANG Yuan, et al. Clinical pathology and anatomy features of parapharyngeal region neoplasms: a report of 69 cases[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2009, 23(3): 113-114, 118. doi:10.3969/j.issn.1001-1781.2009.03.005.
[10] Ijichi K, Murakami S. Surgical treatment of parapharyngeal space tumors: a report of 29 cases[J]. Oncol Lett, 2017, 14(3): 3249-3254. doi:10.3892/ol.2017.6480.
[11] 吕洁瑜, 何炽辉, 周洽锋, 等. 鼻内镜下咽旁间隙解剖研究[J]. 中国耳鼻咽喉颅底外科杂志, 2014, 20(2): 149-151. doi:10.11798/j.issn.1007-1520.201402017. LV Jieyu, HE Zhihui, ZHOU Qiafeng, et al. Endoscopic anatomical study of parapharyngeal space[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2014, 20(2): 149-151. doi:10.11798/j.issn.1007-1520.201402017.
[12] 任昱. 颈动脉损伤诊断与治疗进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(1): 105-109. doi:10.6040/j.issn.1673-3770.0.2019.358. REN Yu. Advances in the diagnosis and treatment of carotid artery injuries[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 105-109. doi:10.6040/j.issn.1673-3770.0.2019.358.
[13] Sun XC, Yan B, Truong HQ, et al. A comparative analysis of endoscopic-assisted transoral and transnasal approaches to parapharyngeal space: a cadaveric study[J]. J Neurol Surg B Skull Base, 2018, 79(3): 229-240. doi:10.1055/s-0037-1606551.
[14] Liu Q, Wang H, Zhao WD, et al. Endoscopic transnasal transmaxillary approach to the upper parapharyngeal space and the skull base[J]. Eur Arch Otorhinolaryngol, 2020, 277(3): 801-807. doi:10.1007/s00405-019-05761-6.
[15] 罗兴谷, 卢永田, 王晓彬. 内镜下经口径路咽旁间隙肿瘤摘除5例[J]. 山东大学耳鼻喉眼学报, 2014, 28(4): 56-58. LUO Xinggu, LU Yongtian, WANG Xiaobin. Surgical treatment of parapharyngeal space tumors via endoscopic transoral approach: a retrospective analyses of 5 cases[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014, 28(4): 56-58.
[16] 张宝莹, 卢永田, 李建兴. 口内径路咽旁间隙的内镜解剖结构[J]. 山东大学耳鼻喉眼学报, 2015, 29(4): 38-41. ZHANG Baoying, LU Yongtian, LI Jianxing. Transoral endoscopic dissection of parapharyngeal space[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015, 29(4): 38-41.
[17] Markou K, Blioskas S, Krommydas A, et al. Transoral resection of giant parapharyngeal space tumors via a combined surgical approach[J]. Iran J Otorhinolaryngol, 2019, 31(103): 87-96.
[18] 邓月, 程寅, 徐亚平, 等. 内镜下低温等离子射频消融切除高位咽旁间隙肿瘤的临床疗效分析[J]. 中国耳鼻咽喉颅底外科杂志, 2019, 25(1): 69-72. doi:10.11798/j.issn.1007-1520.201901014. DENG Yue, CHENG Yin, XU Yaping, et al. Clinical analysis of endoscopic low-temperature plasma radiofrequency ablation for tumors in superior parapharyngeal space[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2019, 25(1): 69-72. doi:10.11798/j.issn.1007-1520.201901014.
[19] 李树华, 石洪金, 吴大海. 经口径路切除巨大咽旁间隙良性肿瘤[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(10): 844-847. doi:10.3760/cma.j.issn.1673-0860.2014.10.011. LI Shuhua, SHI Hongjin, WU Dahai. Resection of macrosis benign parapharyngeal neoplasms via oral approach[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2014, 49(10): 844-847. doi:10.3760/cma.j.issn.1673-0860.2014.10.011.
[20] 侯佳欣,王玲,胡国华. 咽旁间隙肿瘤手术径路及其应用解剖[J]. 中华解剖与临床杂志, 2020,25(1):88-92. doi:10.3760/cma.j.issn.2095-7041.2020.01.016. HOU Jiaxin,WANG Ling,HU Guohua.Surgical approach and applied anatomy of parapharyngeal space tumors[J]. Chinese Journal of Anatomy and Clinics, 2020,25(1):88-92.doi:10.3760/cma.j.issn.2095-7041.2020.01.016.
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