Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (5): 23-27.doi: 10.6040/j.issn.1673-3770.0.2020.536

Previous Articles     Next Articles

Serum 25-(OH)D3 and tissue TGF-β1 levels in patients with chronic rhino sinusitis with nasal polyps and their clinical significance

HAN Jiaqi, YUAN Guoqing, ZHU Yutong, JIANG Feifei, YAN Aihui   

  1. Department of Otolaryngology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China
  • Published:2021-09-29

PDF (PC)

356

Abstract: Objective To investigate the relationship between serum 25-(OH)D3 levels and transforming growth factor-β1(TGF-β1)expression in patients with chronic rhinosinusitis with nasal polyps(CRSwNP). Methods Forty-seven patients with CRSwNP who were diagnosed by pathology were selected as an observation group and 21 patients with maxillary sinus cysts were selected as the control group. The level of serum 25-(OH)D3 and the mean optical density of TGF-β1 in the tissue samples were compared between the two factors. Results The level of serum 25-(OH)D3 in the observation group(16.97±7.35 μg/L)was lower than that in the control group(22.07±11.60 μg/L), the difference was statistically significant (P=0.032); the mean optical density of the TGF-β1 in the nasal polyps(0.052 4±0.019 1)was higher in the observation group than the control group(0.041 0±0.014 5); the difference was statistically significant(P=0.018). There was a significant correlation between serum 25-(OH)D3 levels and TGF-β1 expression in the nasal polyps(R2=0.204,|R|=0.452, P=0.019). Conclusion The level of serum 25-(OH)D3 in patients with CRSwNP decreased, while the expression of TGF-β1 in the nasal polyps increased, and there was a significant correlation between them in CRSwNP.

Key words: 25-(OH)D3, Transforming growth factor-β1, Chronic rhinosinusitis with nasal polyps, Chronic rhinosinusitis, Maxillary sinus cyst, Optical density value

CLC Number: 

  • R765.4
[1] Shi JB, Fu QL, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities[J]. Allergy, 2015, 70(5): 533-539. doi:10.1111/all.12577.
[2] Wierzbicka J, Piotrowska A, Zmijewski MA. The renaissance of vitamin D[J]. Acta Biochim Pol, 2014, 61(4): 679-686.
[3] Carroll WW, Schlosser RJ, O'Connell BP, et al. Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps[J]. Int Forum Allergy Rhinol, 2016, 6(6): 605-610. doi:10.1002/alr.21704.
[4] Wang LF, Chien CY, Tai CF, et al. Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps[J]. Kaohsiung J Med Sci, 2015, 31(2): 63-69. doi:10.1016/j.kjms.2014.11.011.
[5] 张鹤, 张沄, 王宋平. 1, 25-二羟维生素D3通过TGF-β1/(Smad2/3)影响的ROS调节气道重塑[J]. 天津医药, 2020,48(4): 267-270,354. ZHANG He, ZHANG Yun, WANG Songping. Effects of 1,25-dihydroxyvitamin D3 on ROS regulating airway remodeling through TGF-β1/(Smad2/3)[J]. Tianjin Med J, 2020,48(4): 267-270,354.
[6] Hollis BW, Wagner CL. Clinical review: The role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes[J]. J Clin Endocrinol Metab, 2013, 98(12): 4619-4628. doi:10.1210/jc.2013-2653.
[7] Mostafa Bel-D, Taha MS, Abdel Hamid T, et al. Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis[J]. Int Forum Allergy Rhinol, 2016, 6(2): 185-190. doi:10.1002/alr.21585.
[8] Wang F, Yang Y, Chen H. Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps[J]. Am J Otolaryngol, 2019, 40(1): 36-39. doi:10.1016/j.amjoto.2018.09.003.
[9] 赵蓓蓓, 程雅婷, 董衡, 等. 25羟基维生素D检测方法的可靠性分析[J]. 临床儿科杂志, 2017, 35(12): 957-960. doi:10.3969/j.issn.1000-3606.2017.12.020.
[10] Adams JS, Hewison M. Update in vitamin D[J]. Clin Endocrinol Metab, 2010, 95(2): 471-478. doi: 10.1210/jc.2009-1773
[11] Bouillon R, Bischoff-Ferrari H, Willett W. Vitamin D and health: perspectives from mice and man[J]. J Bone Miner Res, 2008, 23(7): 974-979. doi: 10.1359/jbmr.080420
[12] Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity[J]. J Mol Med(Berl), 2010, 88(5): 441-450. doi:10.1007/s00109-010-0590-9.
[13] Wjst M. Is vitamin D supplementation responsible for the allergy pandemic?[J]. Curr Opin Allergy Clin Immunol, 2012, 12(3): 257-262. doi:10.1097/ACI.0b013e3283535833.
[14] Bavi F, Movahed R, Salehi M, et al. Chronic rhinosinusitis with polyposis and serum vitamin D levels[J]. Acta Otorhinolaryngol Ital, 2019, 39(5): 336-340. doi:10.14639/0392-100X-2439.
[15] Rowan CJ, Li W, Martirosyan H, et al. Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling[J]. Development, 2018, 145(13): dev159947. doi:10.1242/dev.159947.
[16] 刘争, 高起学, 张松, 等. 两种细胞外基质糖蛋白在鼻息肉中的表达[J]. 中华耳鼻咽喉科杂志, 2002, 37(3): 173-176. doi:10.3760/j.issn: 1673-0860.2002.03.005. LIU Zheng, GAO Qixue, ZHANG Song, et al. Expression of tenascin and fibronectin in nasal polyps[J]. Chin J Otorhinolaryngol, 2002, 37(3): 173-176. doi:10.3760/j.issn: 1673-0860.2002.03.005.
[17] 郭志娟, 李佩华, 张晓雯. 上皮间质转化状态在内镜治疗慢性鼻窦炎患者预后的预测意义研究[J]. 山东大学耳鼻喉眼学报, 2014,28(1): 34-38. doi:10.6040/j.issn.1673-3770.0.2013.243 GUO Zhijuan, LI Peihua, ZHANG Xiaowen. Prognostic significance of epithelial-mesenchymal transition state in patients with chronic sinusitis treated under endoscopy[J]. J Otolaryngol Ophthalmol Shandong Univ, 2014,28(1): 34-38. doi:10.6040/j.issn.1673-3770.0.2013.243.
[18] Fix C, Carver-Molina A, Chakrabarti M, et al. Effects of the isothiocyanate sulforaphane on TGF-β1-induced rat cardiac fibroblast activation and extracellular matrix interactions[J]. J Cell Physiol, 2019, 234(8): 13931-13941. doi:10.1002/jcp.28075.
[19] 矫健, 张罗. 转化生长因子-β1对慢性鼻-鼻窦炎伴鼻息肉上皮紧密连接屏障功能的影响[J]. 首都医科大学学报, 2018, 39(1): 45-50. doi:10.3969/j.issn.1006-7795.2018.01.009. JIAO Jian, ZHANG Luo. Effect of transforming growth factor-β1 on tight junction barrier function in nasal epithelial cells of chronic rhinosinusitis with nasal polyps[J]. J Cap Med Univ, 2018, 39(1): 45-50. doi:10.3969/j.issn.1006-7795.2018.01.009.
[20] Lee SA, Yang HW, Um JY, et al. Vitamin D attenuates myofibroblast differentiation and extracellular matrix accumulation in nasal polyp-derived fibroblasts through smad2/3 signaling pathway[J]. Sci Rep, 2017, 7(1): 7299. doi:10.1038/s41598-017-07561-6.
[21] Ramirez AM, Wongtrakool C, Welch T, et al. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells[J]. J Steroid Biochem Mol Biol, 2010, 118(3): 142-150. doi:10.1016/j.jsbmb.2009.11.004.
[22] Shany S, Sigal-Batikoff I, Lamprecht S. Vitamin D and myofibroblasts in fibrosis and cancer: at cross-purposes with TGF-β/SMAD signaling[J]. Anticancer Res, 2016, 36(12): 6225-6234. doi:10.21873/anticanres.11216.
[1] FENG Sicong, YU Xiaolan, LOU Dan. Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 31-39.
[2] ZHAI Xuechun, BIAN Xin, CHEN Jingcai, DENG Jiayu, YE Zi, YANG Pingli. Characteristics and influencing factors of anxiety and depression in patients with chronic frontal sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 35-43.
[3] LI Yangsong, YUAN Fayang, YANG Yan, ZHANG Tian, YU Guodong. Bibliometric analysis of biologic agents for the treatment of chronic rhinosinusitis based on the Web of Science database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 54-64.
[4] QIN Nana, LI Yufen, SUN Yuhao, WEI Jian, LI Qin. Effect of interleukin-13 receptor-α2 on nasal mucosal remodeling in rats with allergic rhinitis by TGF-β1/Smad signaling pathway [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 71-77.
[5] ZHANG Jiaqi, YUAN Ye, HONG Chen, GU Min, CHENG Lei, LU Meiping. Mendelian randomization study of gut microbiota, chronic sinusitis, and nasal polyps: Causal relationships and metabolite-mediated effects [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 49-60.
[6] ZHANG Guangling, CHEN Xingxue, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao,WANG Guangke. The expression and function of Tespa1 in chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 35-42.
[7] CAO Zhengyong, LI Xiaobo. Comparison of the safety and efficacy of short-course postoperative topical glucocorticoid adjuvant therapy for eCRSwNP combined with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 43-50.
[8] WANG Aowei, SHI Wenjie. Study on correlation between traditional Chinese medicine syndrome types and TFH cell related factors in CRSwNP [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 54-60.
[9] ZHANG Jie, NIMA Jizong, XU Xiaodong, ZHOU Jing, LIU Jianmin, LUO Yirui, DU Jintao, BA Luo. Effect of Crocin on Type 2 inflammation in eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 61-67.
[10] LI Ting, ZHAO Chong, WU Xian. The relationship between miR-34a expression in nasal mucosa tissue and postoperative recurrence in patients with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 20-25.
[11] CHEN Xingxue, ZHANG Guangling, WU Tianyi, WANG Weiwei, SUN Zhanwei, LI Shichao, WANG Guangke. Analysis of anti-IL-4Rα monoclonal antibody and endoscopic sinus surgery in the treatment of eosinophilic chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 43-54.
[12] ZHANG Shihan, LIU Hongbing. Effect of matrix metalloproteinase on tissue remodeling in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 116-123.
[13] WANG Xiaoai, ZHANG Qianqian, CHENG Xiangyu, LI Zhipeng, ZHANG Weitian, YE Haibo. A clinical efficacy analysis of vidian neurectomy in the treatment of type 2 chronic rhinosinusitis with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 42-49.
[14] ZHU Yu, ZHU Xinhua. Research progress on the role of TH2 cytokines in Type2 chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 156-161.
[15] AO Tian,CHENG Lei. An endotype study of chronic rhinosinusitis with nasal polyps and precise control and treatment under the guidance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 7-14.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd