Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (2): 51-57.doi: 10.6040/j.issn.1673-3770.0.2021.105

Previous Articles     Next Articles

Clinical analysis of 220 cases of deep neck space infection

FENG Yiyuan, YANG Jing, YANG Hongbin   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan, China
  • Published:2022-04-15

Abstract: Objective This study aimed to explore the clinical characteristics, treatment experience, and lessons learned in the treatment of DNI and improve DNI diagnosis and treatment. Methods The clinical characteristics, treatment measures, and prognosis of 220 patients with DNI were retrospectively analyzed. Results Among the 220 patients, 98 with deep cervical space cellulitis were cured by simple anti-infection and symptomatic supportive treatment in 88 cases, whereas 10 cases progressed to deep cervical space abscesses that were cured by further abscess puncture or incision and drainage. The other 122 patients with deep neck space abscesses were treated with anti-infection combined with abscess puncture or incision and drainage and symptomatic supportive treatment. Among them, 12 cases of tuberculosis infectious abscess were administered anti-tuberculosis treatment, 25 were treated with tracheotomy due to complicated severe laryngeal obstruction, and 118 healed. A total of 4 patients died of severe complications. Conclusion DNI is a critical illness. Effective anti-infective measures combined with abscess puncture or incision and drainage is the key to successful treatment. Tuberculosis or other special infections require combination anti-tuberculosis and other special treatments. The timely and correct treatment of comorbidities and complications can reduce mortality and disability rates.

Key words: Deep neck space infection, Cellulitis, Abscess, Surgery, Complication

CLC Number: 

  • R632.4
[1] 李旭茂, 孙广滨. 成人颈深间隙感染诊治研究进展[J]. 中国医学文摘(耳鼻咽喉科学), 2019,34(6): 431-433,423. doi:10.19617/j.issn1001-1307.2019.06.431. LI Xumao, SUN Guangbin. The study of the diagnosis and treatment of deep cervical space infection in adults[J]. Chin Med Dig Otorhinolaryngol, 2019, 34(6): 431-433,423. doi:10.19617/j.issn1001-1307.2019.06.431.
[2] 罗颜, 曹忠胜, 沈红娟, 等. 严重颈深间隙感染患者病原菌分布与治疗研究[J]. 中华医院感染学杂志, 2016,26(9): 2096-2098. doi:10.11816/cn.2016-154113. LUO Yan, CAO Zhongsheng, SHEN Hongjuan, et al. Distribution of pathogens isolated from patients with severe cervical deep space infections and treatment measures[J]. Chin J Nosocomiology, 2016, 26(9): 2096-2098.
[3] 杨晨, 孙祥, 丁家增, 等. 颈深部间隙感染的综合治疗(附12例报告)[J]. 外科理论与实践, 2019,24(2): 135-140. doi:10.16139/j.1007-9610.2019.02.011. YANG Chen, SUN Xiang, DING Jiazeng, et al. Comprehensive treatment of deep neck space infection: a report of 12 cases[J]. J Surg Concepts Pract, 2019, 24(2): 135-140. doi:10.16139/j.1007-9610.2019.02.011.
[4] Li RM, Kiemeney M. Infections of the neck[J]. Emerg Med Clin N Am, 2019, 37(1): 95-107. doi:10.1016/j.emc.2018.09.003.
[5] Celakovsky Petr, Kalfert David, Tucek Lubos, et al. Deep neck infections: risk factors for mediastinal extension[J]. Eur Arch Otorhinolaryngol, 2014, 271:1679-1683. doi: 10.1007/s00405-013-2651-5.
[6] Hasegawa J, Hidaka H, Tateda M, et al. An analysis of clinical risk factors of deep neck infection[J]. Auris Nasus Larynx, 2011, 38(1): 101-107. doi:10.1016/j.anl.2010.06.001.
[7] Gujrathi AB, Ambulgekar V, Kathait P. Deep neck space infection-A retrospective study of 270 cases at tertiary care center[J]. World J Otorhinolaryngol Head Neck Surg, 2016, 2(4): 208-213. doi:10.1016/j.wjorl.2016.11.003.
[8] Brito TP, Hazboun IM, Fernandes FL, et al. Deep neck abscesses: study of 101 cases[J]. Braz J Otorhinolaryngol, 2017, 83(3): 341-348. doi:10.1016/j.bjorl.2016.04.004.
[9] Yuvaraj V, Alexander M, Pasupathy S. Microflora in maxillofacial infections: a changing scenario?[J]. J Oral Maxillofac Surg, 2012, 70(1): 119-125. doi:10.1016/j.joms.2011.02.006.
[10] 孙振龙. 糖尿病和非糖尿病患者合并颌面部间隙感染的临床比较[J]. 河南医学高等专科学校学报, 2015, 27(1): 46-47. doi: 10.3969/J.ISSN.1007-6611.2014.01.013.
[11] Rana RS, Moonis G. Head and neck infection and inflammation[J]. Radiol Clin North Am, 2011, 49(1): 165-182. doi:10.1016/j.rcl.2010.07.013.
[12] Pinto A, Scaglione M, Scuderi MG, et al. Infections of the neck leading to descending necrotizing mediastinitis: Role of multi-detector row computed tomography[J]. Eur J Radiol, 2008, 65(3): 389-394. doi:10.1016/j.ejrad.2007.09.024.
[13] 许雯, 汤玮, 余少卿, 等. 颈部CT、超声与MRI对颈深部脓肿诊断价值的对比研究[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(7): 672-674. doi:10.13201/j.issn.1001-1781.2019.07.024. XU Wen, TANG Wei, YU Shaoqing, et al. Deep neck space infections diagnosis: a comparison between neck CT, ultrasound and MRI[J]. J Clin Otorhinolaryngol Head Neck Surg, 2019,33(7): 672-674. doi:10.13201/j.issn.1001-1781.2019.07.024.
[14] Bal KK, Unal M, Delialioglu N, et al. Diagnostic and therapeutic approaches in deep neck infections: an analysis of 74 consecutive patients[J]. Braz J Otorhinolaryngol, 2020: S1808-S8694(20)30121-X. doi:10.1016/j.bjorl.2020.07.002.
[15] 魏斌宏, 郭红颜, 贺玉良. 颈部结核脓肿的外科治疗[J]. 中国耳鼻咽喉头颈外科, 2011,18(2): 95-96. doi:10.16066/j.1672-7002.2011.02.003.
[16] 黄方, 周小平. 口腔颌面颈部多间隙感染63例[J]. 山东大学耳鼻喉眼学报, 2020,34(6): 104-107. doi: 10.6040/j.issn.1673-3770.0.2019.559. HUANG Fang, ZHOU Xiaoping. Clinical analysis of 63 cases with multiple oral, maxillofacial, and neck infections[J]. J Otolaryngol Ophthalmol Shandong Univ, 2020, 34(6): 104-107. doi: 10.6040/j.issn.1673-3770.0.2019.559.
[17] Boscolo-Rizzo P, Stellin M, Muzzi E, et al. Deep neck infections: a study of 365 cases highlighting recommendations for management and treatment[J]. Eur Arch Otorhinolaryngol, 2012, 269(4): 1241-1249. doi:10.1007/s00405-011-1761-1.
[18] Govea-Camacho LH, Astudillo-Carrera A, Hermosillo-Sandoval JM, et al. Impact of vacuum-assisted closure management in deep neck abscesses[J]. Cir Cir, 2016, 84(4): 275-281. doi:10.1016/j.circir.2015.12.004.
[19] Hyun SY, Oh HK, Ryu JY, et al. Closed suction drainage for deep neck infections[J]. J Craniomaxillofac Surg, 2014, 42(6): 751-756. doi:10.1016/j.jcms.2013.11.006.
[20] 朱新华, 叶吉忠, 陈珮. VSD治疗难愈性创面的临床应用[J]. 中国实用医药, 2015, 10(2): 1-3. doi:10.14163/j.cnki.11-5547/r.2015.02.001. ZHU Xinhua, YE Jizhong, CHEN Pei. Clinical application of VSD in the treatment of refractory wound[J]. China Pract Med, 2015, 10(2): 1-3. doi:10.14163/j.cnki.11-5547/r.2015.02.001.
[21] George S, Ferzli MD,Punam Thakkar MD,et al. Third Branchial Cleft Cyst with Infection[J]. OTO Open, 2017. doi: 10.1177/2473974X17705832.
[22] 彭利, 欧阳晖, 黄河, 等. 食管异物致穿孔并颈部脓肿的诊治[J]. 临床耳鼻咽喉头颈外科杂志, 2016, 30(8): 653-654. doi:10.13201/j.issn.1001-1781.2016.08.018. PENG Li, OUYANG Hui, HUANG He, et al. The diagnosis and treatment of esophageal perforation and neck abscess induced by esophageal foreign body[J]. J Clin Otorhinolaryngol Head Neck Surg, 2016, 30(8): 653-654. doi:10.13201/j.issn.1001-1781.2016.08.018.
[23] Li WX, Dong YB, Zhang AB, et al. Management of deep neck infections from cervical esophageal perforation caused by foreign body: a case series study[J]. Am J Otolaryngol, 2021, 42(2): 102870. doi:10.1016/j.amjoto.2020.102870.
[24] 吴博, 胡国华. 异物致颈部脓肿三例并文献复习[J]. 山东大学耳鼻喉眼学报, 2017,31(1): 100-102,106. doi: 10.6040/j.issn.1673-3770.0.2016.341. WU Bo, HU Guohua. Foreign body induced cervical abscess in 3 cases and literature view[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017,31(1): 100-102,106. doi: 10.6040/j.issn.1673-3770.0.2016.341.
[25] Swain S, Baliarsingh P, Panda S. Deep neck space infection of the pediatric patients: Our experiences at a tertiary care teaching hospital of Eastern India[J]. Amrita J Med, 2020, 16(4): 169. doi:10.4103/amjm.amjm_52_20.
[26] Sánchez-Gollarte A, Mugüerza-Huguet JM, Díez-Alonso MM, et al. Septic thrombosis of internal jugular vein: a rare cause of uncontrollable hiccups[J]. J Surg Case Rep, 2019, 2019(9): rjz266. doi:10.1093/jscr/rjz266.
[27] Bendiouri R, Chennoufi I, Lachkar A, et al. Internal jugular vein thrombosis by sewing needle ingestion[J]. Int J Surg Case Rep, 2021, 83: 105988. doi:10.1016/j.ijscr.2021.105988.
[28] 王卫东, 孙宏亮, 骆江红, 等. 覆膜支架腔内修复治疗颈动脉假性动脉瘤破裂出血[J]. 介入放射学杂志, 2017,26(1): 15-19. doi: 10.3969/j.issn.1008-794X.2017.01.004. WANG Weidong, SUN Hongliang, LUO Jianghong, et al. Endovascular repair with covered stent for the treatment of ruptured carotid artery pseudoaneurysms[J]. J Interv Radiol, 2017, 26(1): 15-19. doi: 10.3969/j.issn.1008-794X.2017.01.004.
[29] Harada T, Fujita A, Sakata J, et al. Endovascular internal trapping by low-concentration N-butyl-2-cyanoacrylate for a ruptured giant common carotid artery pseudoaneurysm[J]. Vasc Endovascular Surg, 2021, 55(1): 81-85. doi:10.1177/1538574420953942.
[30] 任昱, 肖旭平. 颈动脉损伤诊断与治疗进展[J]. 山东大学耳鼻喉眼学报, 2020,34(1): 105-109. doi: 10.6040/j.issn.1673-3770.0.2019.358. REN Yu, XIAO Xuping. Advances in the diagnosis and treatment of carotid artery injuries[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020,34(1): 105-109. doi: 10.6040/j.issn.1673-3770.0.2019.358.
[31] Saito Y, Asami M, Miki A, et al. Deep neck infection complicated by phlegmonous esophagitis and mediastinitis[J]. Ann Thorac Surg, 2021, 111(6): e403-e406. doi:10.1016/j.athoracsur.2020.08.101.
[1] ZHANG Guomin, WANG Maohua, GAO Song, WU Wenbin, YU Youjun. Analysis of the surgical efficacy of adhesive otitis media under continuous irrigating mode for endoscopic ear surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 16-19.
[2] LU Zhaoyang, ZHAI Zhaoxue, WANG Huikang, SHAO Liting, ZHANG Yu. COVID-19 treatment-induced diabetic ketoacidosis combined with rhino-orbital cerebral mucormycosis: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 90-94.
[3] CHENG Zhuo, LIANG Hui, XING Lumin. Research progress and prospect analysis of deep learning technology in the application of pharyngeal and laryngeal endoscopy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 112-119.
[4] CHEN Tao, JIANG Yang, LI Ying. SMILE correction of refractive regression after PRK surgery: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 148-153.
[5] HUANG Qi, DENG Xuwen, WANG Peipei, CHEN Yequn, GU Xuejun. Research on evaluating the cataract surgery level of ophthalmologists using eyeSi surgical simulator [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 83-88.
[6] XIE Xian, CHEN Yi, LIU Bin, XIAO Xuping, LI Xiangsheng. A case of temporal bone hypercavitation with infectious shock and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 108-113.
[7] WANG Zaixing, TANG Zhiyuan, LI Dingbo, SHI Zhaohui, ZENG Xianhai, ZHANG Qiuhang. Treatment of internal carotid artery rupture caused by tumor recurrence and skull base osteonecrosis after radiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 49-58.
[8] SUN Fang, XIE Chubo, QIU Qianhui. Retrospective analysis of nutritional indexes and their impact on wound healing in patients with radiation-induced skull base osteoradionecrosis after treatment with nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 59-68.
[9] JIANG Zhilin, ZHU Ruikai, QIU Qianhui. Imaging-based observation and analysis of the pharyngeal internal carotid artery trajectory [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 69-76.
[10] WU Jiarong, QIU Qianhui. The role and significance of the skull base fascial tissue barrier in endoscopic resection of locally early recurrent nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 108-113.
[11] GUO Rongchang, LIU Qinghang, WANG Hongzeng, SUN Shujun. Through the orbit with sinus huge foreign bodies embedded in the base of the skull: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 135-141.
[12] GU Yuelong, TANG Ru, MAO Song, ZHANG Weitian. Predictive value of postoperative GH and IGF-1 levels for long-term remission in non-invasive growth hormone-secreting pituitary adenoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 45-50.
[13] MA Xin, DONG Lingkang, WU Hongmin, YI Hongliang, ZOU Jianyin. Modifications and applications of lateral expansion abduction suspension suture technique in the treatment of obstructive sleep apnea [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 81-88.
[14] WANG Wenqing, ZHANG Dan, ZHU Mengdi, WANG Luyang, YANG Peipei, SUN Sisi, ZHANG Qiumin, ZHOU Hui. Changes of clinical and histopathological characteristics in recurrent chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 46-53.
[15] HOU Jing, FANG Gaoli, ZHOU Bing. Formation mechanism and cyst fluid composition analysis of nasal mucosal cysts after functional endoscopy sinus surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 1-5.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!