JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression of Jab1 in laryngeal squamous cell carcinoma

ZHANG Feng,CAO Hua   

  1. Department of Otolaryngology, First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052, Henan, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: ZHANG Feng

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Abstract: Objective: To study the expression of Jab1(c-Jun activation domain-binding protein 1) in laryngeal squamous cell carcinoma (LSCC) and its correlation with clinicopathologic variables and prognosis. Methods: Expression of Jab1 protein was determined by SP immunohistochemistry in 23 cases of normal laryngeal tissues and 72 cases of LSCC. Results: Jab1 over-expression was produced in 54.17% of LSCC and was significantly positively associated with clinicopathologic variables and lymph node metastasis. Survival analysis revealed that Jab1 over-expression was significantly negatively associated with the overall survival (P<0.05). Conclusions: Jab1 protein may contribute to the development and progression of LSCC by facilitating the degradation of p27kip1 and represents a novel prognostic indicator for LSCC.

Key words: Laryngeal neoplasms, Carcinoma, squamous cells, Immunohistochemistry, Jab1

CLC Number: 

  • R767.19
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