山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (1): 110-113.doi: 10.6040/j.issn.1673-3770.0.2016.328

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玻璃体腔注射雷珠单抗联合GLP治疗BRVO-ME的临床观察

严槟,尹小芳,叶祖科,卢彦,洪剑威   

  1. 广东省佛山市第二人民医院眼科中心, 广东 佛山 528000
  • 收稿日期:2016-07-27 出版日期:2017-02-16 发布日期:2017-02-16
  • 基金资助:
    广东省佛山市科技计划项目(2015122)

Clinical observation on the treatment of BRVO-ME by the combination of laser therapy with Ranibizumab intravitreal injection.

  1. Department of Ophthalmology, Second Peoples Hospital of Foshan, Foshan 528000, Guangdong, China
  • Received:2016-07-27 Online:2017-02-16 Published:2017-02-16

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摘要： 目的 研究视网膜分支静脉阻塞继发黄斑水肿(BRVO-ME)患者应用雷珠单抗玻璃体腔注射联合格栅样视网膜激光光凝术(GLP)治疗的临床效果。 方法 选取135例(135眼)BRVO-ME临床资料,随机分为单纯药物组(n=45)、单纯激光组(n=45)、联合治疗组(n=45),单纯药物组仅应用雷珠单抗玻璃体腔注射,单纯激光组仅应用GLP治疗,联合治疗组先予雷珠单抗玻璃体腔注射,间隔1周后应用GLP治疗。 结果 三组治疗3个月后最佳矫正视力(BCVA)水平对比,较治疗前差异有统计学意义(P<0.05),且联合治疗组治疗1、2、3个月后BCVA水平较同期单纯药物组、单纯激光组差异有统计学意义(P<0.05)。三组治疗3个月后黄斑中心凹视网膜厚度(CMT)水平对比,均较治疗前差异有统计学意义(P<0.05),且联合治疗1、2、3个月后CMT水平较同期单纯药物组、单纯激光组差异均有统计学意义(P<0.05)。 结论 玻璃体腔注射雷珠单抗联合GLP治疗BRVO-ME较单纯药物和单纯激光治疗,降低黄斑中心凹视网膜厚度、改善黄斑水肿、提高视力效果更明显,复发率更低,安全有效。

关键词: 视网膜激光光凝术, 雷珠单抗, 视网膜分支静脉阻塞, 黄斑水肿

Abstract: Objective To explore the clinical efficacy of branch retinal vein occlusion secondary macular edema(BRVO-ME)treated with Ranibizumab intravitreal injection combined with grille laser photocoagulation(GLP). Methods A total of 135(135 eyes)BRVO-ME cases were divided into 3 groups: simple drug group(n=45), simple laser group(n=45), and combined treatment group(n=45). The simple drug group received Ranibizumab intravitreal injection only. The simple laser group received GLP only. The combined treatment group received Ranibizumab intravitreal injection first, and then GLP 1 week after. The best corrected visual acuity(BCVA), central macular thickness(CMT), and intraocular pressure(IOP)of the 3 groups were observed. Results Three months after treatment, BCVA and CMT of all groups were significantly different(P<0.05). The combined treatment group had significantly lower BCVA and CMT than the other 2 groups in postoperative month 1, 2 and 3(P<0.05). During the treatment, no increased IOP was observed(P>0.05). No postoperative infection, vitreous hemorrhage, bacterial endophthalmitis or other adverse reactions occurred. Conclusion Ranibizumab intravitreal injection combined with GLP is safe and effective in the treatment of BRVO-ME, which can reduce the CMT, relieve macular edema, and improve visual acuity.

Key words: Ranibizumab, Grille laser photocoagulation, Branch retinal vein occlusion, Macular edema

中图分类号: 

  • R774.5
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