山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (1): 35-40.doi: 10.6040/j.issn.1673-3770.0.2021.494
• 论著 • 上一篇
张晓雪1,王伟2,刘杰1,许贞菊1,钱永恒1,韩敏1
ZHANG Xiaoxue1, WANG Wei2, LIU Jie1, XU Zhenju1, QIAN Yongheng1, HAN Min1
摘要: 目的 分析儿童与成人阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者口咽部菌群的差异及其药敏学结果,为临床OSAHS患者术后合理选择抗生素提供参考依据。 方法 选取青岛大学附属医院耳鼻咽喉头颈外科2018年1月—2021年10月经多导睡眠监测确诊并行手术治疗的OSAHS患者为研究对象,根据年龄分为儿童组和成人组,入院后取2组患者口咽部分泌物及时送检行细菌培养及药敏学分析,比较儿童OSAHS患者与成人OSAHS患者的口咽部菌群差异及药敏学结果。 结果 211例患者中66例分离培养出病原菌共78株,阳性率为31.28%,其中革兰氏阳性球菌55株(70.51%),以金黄色葡萄球菌29株(37.18%)、肺炎链球菌18株(23.08%)为主;革兰氏阴性杆菌19株(24.36%),以流感嗜血杆菌15株(19.23%)为主。儿童组与成人组相比,致病菌检出率差异有统计学意义;肺炎链球菌2组间比较,差异有统计学意义,儿童组肺炎链球菌的检出率高于成人组;金黄色葡萄球菌、流感嗜血杆菌2组间比较,差异均无统计学意义。肺炎链球菌对四环素、克林霉素、红霉素具有较高的耐药率;金黄色葡萄球菌对青霉素的耐药率较高;流感嗜血杆菌对氨苄西林、头孢克洛、复方新诺明、头孢呋辛的耐药率较高。 结论 OSAHS术后经验性应用抗生素预防和治疗感染,儿童患者与成人患者应区别对待,并应根据药敏结果及时调整抗菌药物方案,减缓耐药菌的产生。
中图分类号:
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